In vitro metabolism of testosterone to 17ß-hydroxy-5α-androstane-3-one and 5α-androstane-3α, 17ß-diol by the rat intestine

Stenstad, Per; Eik‐Nes, Kristen B.

doi:10.1016/0022-4731(82)90633-1

Cited by 11 publications

(5 citation statements)

References 15 publications

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“…The negative correlation between the extent of ulceration and level of plasma corticosterone is puzzling because both measures have often been assumed to directly index stress exposure, implying a positive correlation Obviously, this simple assumption is incorrect and some complexly mediated interplay between these two vanables must exist for animals under stress. There are reasons to suggest that corticosterone does play some protective role for the organism in so far as gastnc ulceration is concerned For example, Brodie and Hanson (1960) reported that adrenalectomy increased ulceration in response to a given challenge More recently, Stenstad and Eik-Nes (1982) have suggested that corticoids activate gastrointestinal mucosal regenerating enzymes in cows Thus, corticoids may be intimately involved in both ulcerogenic and recuperative processes, and the net observation may be a function of the relative activation of these two competing processes as a function of corticoid level and their relative time courses…”

Section: Resultsmentioning

confidence: 99%

“…For example, Brodie and Hanson (1960) reported that adrenalectomy increased ulceration in response to a given challenge. More recently, Stenstad and Eik-Nes (1982) have suggested that corticoids activate gastrointestinal mucosal regenerating enzymes in cows. Thus, corticoids may be intimately involved in both ulcerogenic and recuperative processes, and the net observation may be a function of the relative activation of these two competing processes as a function of corticoid level and their relative time courses.…”

Section: Discussionmentioning

confidence: 99%

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Quality of poststressor rest influences the ulcerative process.

Overmier¹,

Murison²,

Ursin³

et al. 1987

Behavioral Neuroscience

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Gastric ulceration in rats is exacerbated by allowing a so-called recovery period after exposure to an ulcerogenic stressor. One hypothesis, which has support from pharmacological studies, argues that this effect is brought about by a rebound of parasympathetic activation. We tested this parasympathetic rebound hypothesis by presenting animals with a fear-inducing (sympathetic-activating) conditioned stimulus (CS) after 2 hr of water-restraint stress. Contrary to the hypothesis, presentation of such a CS increased severity of ulceration compared with those animals that did not receive the CS after restraint stress and control animals. These ulceration data favor instead a sustained activation hypothesis for ulceration, whereby presentation of the CS effectively prolonged the length of time during which animals were under stress, thus enhancing the degree of ulceration. Measurement of plasma corticosterone however indicated a negative correlation between adrenocortical activity and degree of gastric ulceration, contrary to that expected by a sustained activation hypothesis. It is suggested that this inconsistency may be because of the activating of a pituitary-endorphinogenic mediated stress analgesia.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Quality of poststressor rest influences the ulcerative process.

Overmier¹,

Murison²,

Ursin³

et al. 1987

Behavioral Neuroscience

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“…The reports on application of animals tissues for this purpose suggest that the formation of allyl alcohols is probably inconsistent with the earlier recognized methabolic pathway in the organisms of mammals. In that pathway, testosterone transformation consist of the reduction of the 4,s bond and the subsequent reduction of the carbonyl group at C-3 to the final product such as 3,17-dihydroxy-5cc-or 5P-androstane (STENSTAD and EIK-NES 1982).…”

Section: Discussionmentioning

confidence: 99%

Reduction of testosterone, androstendione and their derivatives by Aphanocladium album

Dmochowska-Gładysz

Kołek

Siewiński

1989

J. Basic Microbiol.

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A strain of Aphanocladium album reduces the C-3 carbonyl group in testosterone or androstendione to to 3 alpha-allyl alcohol. In some derivatives of these steroids the same carbonyl group is reduced to allyl alcohol with stereospecificity, depending on whether chlorine at C-4 or a 17 alpha-methyl group is present. On the other hand, the presence of C-4 methyl group, a C-19 hydroxy group, a C-17 acetyl one, or a double bond conjugated with the 4-en-3- ketone system totally inhibits the formation of allyl alcohols at C-3. At the same time, the C-17 carbonyl group in androstendione or in its derivatives is reduced to a respective 17 beta-alcohol. In the derivatives with an additional 2-exomethylene group the double bond at this group is reduced.

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“…Testosterone is not normally associated with ion transport control but has a well-established role in intestinal cell proliferation and differentiation (Wright, Morley & Appleton, 1972). It is believed to act through metabolites, and recent work by Stenstad & Eik Nes (1982) has shown that glucocorticoid activation of the intestine augments the metabolism of testosterone into its biologically active forms.…”

Section: Discussionmentioning

confidence: 99%

Developmental aspects of steroid‐induced ammonia release from isolated sections of rat intestine.

Coates¹,

Snart²

1984

The Journal of Physiology

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Release of ammonia from isolated intestinal sections of adult male rats is higher than that measured using immature animals. The increase appears to be Na+ dependent and develops during the spurt of growth at puberty. Developmental changes in Na+-dependent ammonia release from isolated sections of the intestine and growth of the small intestine in male and female rats have been compared. Intestinal growth increases far more rapidly than body weight and in the males critical developmental changes occur early during weaning and during puberty. In females the major change is at weaning and little further change occurs during puberty. Treatment of young animals with aldosterone or testosterone increases the Na+-dependent ammonia release precociously. Dose-response effects of testosterone and aldosterone in distal sections of the small intestine have been compared.

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In vitro metabolism of testosterone to 17ß-hydroxy-5α-androstane-3-one and 5α-androstane-3α, 17ß-diol by the rat intestine

Cited by 11 publications

References 15 publications

Quality of poststressor rest influences the ulcerative process.

Quality of poststressor rest influences the ulcerative process.

Reduction of testosterone, androstendione and their derivatives by Aphanocladium album

Developmental aspects of steroid‐induced ammonia release from isolated sections of rat intestine.

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