In vitro measurements of burn dressing adherence and the effect of interventions on reducing adherence

Brichacek, Michal; Ning, Chengcheng; Gawaziuk, Justin P.; Liu, Song; Logsetty, Sarvesh

doi:10.1016/j.burns.2017.01.012

Cited by 7 publications

(3 citation statements)

References 12 publications

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“…NSAIDs-based local burn management currently relies upon the use of biodegradable and non-biodegradable biopolymers as potential carriers for controlled drug delivery systems (also called drug dressings) [ 23 ]. Such NSAIDs-based drug delivery systems (DDS) with non-biodegradable polymers support are to be avoided as they need frequent replacements that affect a patient’s comfort and can cause additional trauma to the new epithelial tissue formed, the risk of secondary infection being very high [ 7 , 9 , 24 , 25 , 26 , 27 ]. Therefore, biodegradable polymers are considered to be ideal vehicles for drugs delivery [ 28 ], collagen being preferred due to its properties such as biodegradability, bioresorbability, biocompatibility, hemostasis ability, well-known structure, and reduced manufacturing cost [ 29 , 30 , 31 , 32 , 33 , 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Development, Optimization and In Vitro/In Vivo Characterization of Collagen-Dextran Spongious Wound Dressings Loaded with Flufenamic Acid

et al. 2017

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The aim of this study was the development and optimization of some topical collagen-dextran sponges with flufenamic acid, designed to be potential dressings for burn wounds healing. The sponges were obtained by lyophilization of hydrogels based on type I fibrillar collagen gel extracted from calf hide, dextran and flufenamic acid, crosslinked and un-crosslinked, and designed according to a 3-factor, 3-level Box-Behnken experimental design. The sponges showed good fluid uptake ability quantified by a high swelling ratio. The flufenamic acid release profiles from sponges presented two stages—burst effect resulting in a rapid inflammation reduction, and gradual delivery ensuring the anti-inflammatory effect over a longer burn healing period. The resistance to enzymatic degradation was monitored through a weight loss parameter. The optimization of the sponge formulations was performed based on an experimental design technique combined with response surface methodology, followed by the Taguchi approach to select those formulations that are the least affected by the noise factors. The treatment of experimentally induced burns on animals with selected sponges accelerated the wound healing process and promoted a faster regeneration of the affected epithelial tissues compared to the control group. The results generated by the complex sponge characterization indicate that these formulations could be successfully used for burn dressing applications.

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Section: Introductionmentioning

confidence: 99%

Development, Optimization and In Vitro/In Vivo Characterization of Collagen-Dextran Spongious Wound Dressings Loaded with Flufenamic Acid

et al. 2017

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“…Another approach is the use of soft silicone 19 or even waxes 20 to prevent dressings from sticking to the wound surface. Successful relying of decreased adherence is measured by in vitro models based for instance on gelatine bodies and examination of removal forces after dressing appliance 21 . Yet, dressing applicability is not only described by easing detachment but further requires good cell compatibility.…”

Section: Discussionmentioning

confidence: 99%

Effect of non-adhering dressings on promotion of fibroblast proliferation and wound healing in vitro

Wiegand

Abel

Hipler

et al. 2019

Sci Rep

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Non-adhering dressings are commonly used during granulation, tissue formation, and re-epithelialization. Elucidating cytotoxic effects and influence on proliferation/migration capacity of cells like fibroblasts is of interest. Dressings’ effects were investigated by comprehensive in vitro approach: (1) MTT assay measuring cell viability after direct contact, (2) ATP assay determining effects on cell proliferation, and (3) scratch wound assay featuring an in vitro wound healing model. One cotton-based dressing with vaseline (vas) was included in the study and four polyester dressings containing vas and technology-lipido-colloid matrix (TLC), carboxymethylcellulose (CMC), hydrocolloid (HC), or glycerin (gly) as additives. A polyamide dressing with vas + CMC and three silicone-based dressings (AT, CC, M) were tested. Polyester + vas + CMC did not negatively affect cell viability or proliferation but it was found that fibroblast layers appeared more irregular with decreased F-actin network structure and tubulin density possibly leading to hampered scratch closure. Silicone AT, polyester + gly and polyamide + vas + CMC caused distinct cell damage. The latter two further reduced cell viability, proliferation and scratch healing. From the overall results, it can be concluded that cotton + vas, polyester + TLC, polyester + vas + HC and the silicone dressings CC and M have the potential to prevent damage of newly formed tissue during dressing changes and positively influence wound healing.

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“…Based on the Andrews and Kamyab in vitro gelatin model, the adhesive situation of wound seepage on the material was simulated and the anti-adhesive property was characterized by the peeling energy of gelatin-material. [27][28][29] Firstly, the sample of 3 × 15 cm 2 was immersed in deionized water for 5 min and tiled on the clean surface. A PTFE mold was placed on the surface (Figure 2(a)).…”

Section: Adhesion Resistance Test In Vitromentioning

confidence: 99%

Hydrophobic modification of mesh spunlace nonwoven for medical dressing contact layer

Gu,

Wang,

Dai

et al. 2023

Journal of Industrial Textiles

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The contact layer of traditional medical dressing is easy to adhere to the new wound granulation tissue, which brings the deficiency of secondary wound injury. This work assumed that low-cost and soft mesh spunlace nonwoven was used as medical dressing contact layer. After micro-nano SiO2 modification, polydimethylsiloxane (PDMS)/n-heptane were uniformly sprayed on the surface of materials. PDMS modification was studied by using the three-factor three-level orthogonal experiment. The results showed that when the PDMS concentration was 1%, the heat treatment temperature and time were 120°C and 12 h respectively, material possessed the optimal hydrophobicity and its water contact angle (CA) was 151.0 ± 1.1°. Meanwhile, the hydrophobicity, microstructure, thermogravimetry, composition, tensile mechanics, adhesion resistance and durability of materials with/without treatment were compared. It was proved that PDMS was indeed grafted onto the material and could effectively improve the hydrophobicity in coordination with micro-nano SiO2 without affecting the mesh structure of material. The machine direction (MD) and cross-machine direction (CD) strength of material decreased but the elongation increased slightly. The MD and CD peeling energy was 129.7 ± 33.9 J/m2 and 98.1 ± 38.3 J/m2, respectively. Moreover, the water CA of material modified by micro-nano SiO2/PDMS was still 139.4 ± 1.4° after 10 friction stroke tests, indicating that the modified material possessed the great durability. Overall, this study can provide the research basis for the development of anti-adhesion medical dressing contact layer.

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In vitro measurements of burn dressing adherence and the effect of interventions on reducing adherence

Cited by 7 publications

References 12 publications

Development, Optimization and In Vitro/In Vivo Characterization of Collagen-Dextran Spongious Wound Dressings Loaded with Flufenamic Acid

Development, Optimization and In Vitro/In Vivo Characterization of Collagen-Dextran Spongious Wound Dressings Loaded with Flufenamic Acid

Effect of non-adhering dressings on promotion of fibroblast proliferation and wound healing in vitro

Hydrophobic modification of mesh spunlace nonwoven for medical dressing contact layer

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