In vitro Maturation (IVM) of human oocytes

Strowitzki, T.

doi:10.1007/s00404-013-3033-3

Cited by 8 publications

(4 citation statements)

References 31 publications

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“…Current literature on IVM in humans focuses mainly on its effectiveness or related culture conditions [217][218][219], with few studies comparing different insemination protocols. One such study included 8 PCOS patients treated in 8 IVM cycles where sibling oocytes were equally inseminated by IVF or ICSI.…”

Section: In Vitro Maturationmentioning

confidence: 99%

Thoughts on the popularity of ICSI

Haddad

Stewart

Xie

et al. 2020

J Assist Reprod Genet

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Purpose Intracytoplasmic sperm injection (ICSI) is the most widely utilized assisted reproductive technique (ART) worldwide. In this feature, we review the early assisted fertilization attempts that eventually led to the development of ICSI, and discuss its current utilization in cases of male and non-male factor infertility. Methods We researched the literature related to the development, indications, and current use of ICSI, such as sperm structural abnormalities, male genetic indications, surgically retrieved sperm, high sperm chromatin fragmentation, oocyte dysmorphism, and preimplantation genetic testing (PGT). We also describe the potential future applications of ICSI. Results This review summarizes the early micromanipulation techniques that led to the inception of ICSI. We also explore its current indications, including non-male factor infertility, where its use is more controversial. Finally, we consider the benefits of future advancements in reproductive biology that may incorporate ICSI, such as in vitro spermatogenesis, neogametogenesis, and heritable genome editing. Conclusion The versatility, consistency, and reliability of ICSI have made it the most prevalently utilized ART procedure worldwide.

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Section: In Vitro Maturationmentioning

confidence: 99%

Thoughts on the popularity of ICSI

Haddad

Stewart

Xie

et al. 2020

J Assist Reprod Genet

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“…On the other hand, IVM protocols to promote maturation of oocytes collected from unstimulated ovaries exist and they are employed in several fertility centers around the world, as an alternative to classical, stimulated cycles [ 30 – 32 ]. The present results show that implantation and gestation rates after IVM are close to those obtained in classical stimulated cycles.…”

Section: Parthenogenetic Activation Methodologiesmentioning

confidence: 99%

Parthenogenesis and Human Assisted Reproduction

Bös-Mikich

Bressan

Ruggeri

et al. 2015

Stem Cells International

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Parthenogenetic activation of human oocytes obtained from infertility treatments has gained new interest in recent years as an alternative approach to create embryos with no reproductive purpose for research in areas such as assisted reproduction technologies itself, somatic cell, and nuclear transfer experiments and for derivation of clinical grade pluripotent embryonic stem cells for regenerative medicine. Different activating methods have been tested on human and nonhuman oocytes, with varying degrees of success in terms of parthenote generation rates, embryo development stem cell derivation rates. Success in achieving a standardized artificial activation methodology for human oocytes and the subsequent potential therapeutic gain obtained from these embryos depends mainly on the availability of gametes donated from infertility treatments. This review will focus on the creation of parthenotes from clinically unusable oocytes for derivation and establishment of human parthenogenetic stem cell lines and their potential applications in regenerative medicine.

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“…IVM is a cutting-edge technique in the field of in vitro fertilization (IVF), in which immature eggs are removed from the ovaries after the application of ovulation stimulating drugs and then are in vitro cultured from GV or pre-GV stage to MII stage [ 46 , 47 ]. Utilization of immature oocytes is an important component of ART [ 48 ].…”

Section: Melatonin Promotes In Vitro Oocyte Maturationmentioning

confidence: 99%

Applications of Melatonin in Female Reproduction in the Context of Oxidative Stress

Jiang

Shi

Liu

et al. 2021

Oxidative Medicine and Cellular Longevity

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Oxidative stress has been recognized as one of the causal mediators of female infertility by affecting the oocyte quality and early embryo development. Improving oxidative stress is essential for reproductive health. Melatonin, a self-secreted antioxidant, has a wide range of effects by improving mitochondrial function and reducing the damage of reactive oxygen species (ROS). This minireview illustrates the applications of melatonin in reproduction from four aspects: physiological ovarian aging, vitrification freezing, in vitro maturation (IVM), and oxidative stress homeostasis imbalance associated with polycystic ovary syndrome (PCOS), emphasising the role of melatonin in improving the quality of oocytes in assisted reproduction and other adverse conditions.

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In vitro Maturation (IVM) of human oocytes

Cited by 8 publications

References 31 publications

Thoughts on the popularity of ICSI

Thoughts on the popularity of ICSI

Parthenogenesis and Human Assisted Reproduction

Applications of Melatonin in Female Reproduction in the Context of Oxidative Stress

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