Applications of Melatonin in Female Reproduction in the Context of Oxidative Stress

Jiang, Yonghui; Shi, Huangcong; Liu, Yue; Zhao, Shigang; Zhao, Han

doi:10.1155/2021/6668365

Cited by 34 publications

(22 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been found that melatonin is present in high concentrations in human follicular fluid [ 208 ]. Melatonin has a good antioxidant effect by neutralizing free radicals and increasing the activity of antioxidant enzymes such as SOD and GSH-Px [ 209 ]. As an important endogenous antioxidant, its antioxidant properties are superior to conventional antioxidants, such as vitamin C and E [ 210 ].…”

Section: Additional Antioxidant Therapy That Can Improve Ovarian Agingmentioning

confidence: 99%

The role of oxidative stress in ovarian aging: a review

et al. 2022

View full text Add to dashboard Cite

Ovarian aging refers to the process by which ovarian function declines until eventual failure. The pathogenesis of ovarian aging is complex and diverse; oxidative stress (OS) is considered to be a key factor. This review focuses on the fact that OS status accelerates the ovarian aging process by promoting apoptosis, inflammation, mitochondrial damage, telomere shortening and biomacromolecular damage. Current evidence suggests that aging, smoking, high-sugar diets, pressure, superovulation, chemotherapeutic agents and industrial pollutants can be factors that accelerate ovarian aging by exacerbating OS status. In addition, we review the role of nuclear factor E2-related factor 2 (Nrf2), Sirtuin (Sirt), mitogen-activated protein kinase (MAPK), protein kinase B (AKT), Forkhead box O (FoxO) and Klotho signaling pathways during the process of ovarian aging. We also explore the role of antioxidant therapies such as melatonin, vitamins, stem cell therapies, antioxidant monomers and Traditional Chinese Medicine (TCM), and investigate the roles of these supplements with respect to the reduction of OS and the improvement of ovarian function. This review provides a rationale for antioxidant therapy to improve ovarian aging.

show abstract

Section: Additional Antioxidant Therapy That Can Improve Ovarian Agingmentioning

confidence: 99%

The role of oxidative stress in ovarian aging: a review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Its concentration in porcine follicular fluid is approximately 10 −11 M, which is negatively correlated with follicle size, with a trend of smaller follicles and higher melatonin content ( Shi et al, 2009 ). Melatonin promotes in vitro maturation and parthenogenetic development of porcine oocytes in a dose-dependent manner, but high concentrations have negative effects ( Shi et al, 2009 ; Jin et al, 2017 ), in two ways ( Jiang et al, 2021 ). It either directly chelates oxygen and nitrogen reactive species as well as mobilizes the antioxidant enzyme in cells ( Amaral and Cipolla-Neto, 2018 ) or binds to its receptors ( Reiter et al, 2014 ) to decrease downstream molecules, such as cAMP and cGMP, as well as increase PLC ( Jockers et al, 2016 ), to mitigate oxidative stress in the female reproductive system.…”

Section: Discussionmentioning

confidence: 99%

Glycine and Melatonin Improve Preimplantation Development of Porcine Oocytes Vitrified at the Germinal Vesicle Stage

Tang

Zhang

Liu

et al. 2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Lipid-rich porcine oocytes are extremely sensitive to cryopreservation compared to other low-lipid oocytes. Vitrification has outperformed slowing freezing in oocyte cryopreservation and is expected to improve further by minimizing cellular osmotic and/or oxidative stresses. In this study, we compared the effects of loading porcine cumulus-oocyte complexes with glycine (an organic osmolyte) or glycine plus melatonin (an endogenous antioxidant) during vitrification, thawing and subsequent maturation to mitigate osmotic injuries or osmotic and oxidative damages on the developmental potential of porcine oocytes. Our data demonstrated that glycine treatment significantly increased the vitrification efficiency of porcine oocytes to levels comparable to those observed with glycine plus melatonin treatment. It was manifested as the thawed oocyte viability, oocyte nuclear maturation, contents of reactive oxygen species, translocation of cortical granules and apoptotic occurrence in mature oocytes, levels of ATP and transcripts of glycolytic genes in cumulus cells (markers of oocyte quality), oocyte fertilization and blastocyst development. However, the latter was more likely than the former to increase ATP contents and normal mitochondrial distribution in mature oocytes. Taken together, our results suggest that mitigating osmotic and oxidative stresses induced by vitrification and thawing can further enhance the developmental competency of vitrified porcine oocytes at the germinal vesicle stage.

show abstract

“…Melatonin (N‐acetyl‐5‐methoxytryptamine) is an endogenous indoleamine hormone produced mainly by the pineal gland modulating several important physiological reactions. 90 , 91 Functioning as an antioxidant, melatonin and its derivatives protects cells from oxidation, inflammation, and apoptosis. 92 …”

Section: Therapeutics Involving the Sirt Signaling Pathway To Improve...mentioning

confidence: 99%

Improvement of oocyte quality through the SIRT signaling pathway

Sato

Kawamura

2023

Reprod Medicine & Biology

View full text Add to dashboard Cite

Background Oocyte quality is one of the major deciding factors in female fertility competence. Methods PubMed database was searched for reviews by using the following keyword “oocyte quality” AND “Sirtuins”. The methodological quality of each literature review was assessed using the Preferred Reporting Items for Systematic reviews and Meta‐Analyses (PRISMA) 2020 statement. Main Findings Oxidative stress has been recognized as the mechanism attenuating oocyte quality. Increasing evidence from animal experiments and clinical studies has confirmed the protective roles of the sirtuin family in improving oocyte quality via an antioxidant effect. Conclusion The protective roles in the oocyte quality of the sirtuin family have been increasingly recognized.

show abstract

Applications of Melatonin in Female Reproduction in the Context of Oxidative Stress

Cited by 34 publications

References 98 publications

The role of oxidative stress in ovarian aging: a review

The role of oxidative stress in ovarian aging: a review

Glycine and Melatonin Improve Preimplantation Development of Porcine Oocytes Vitrified at the Germinal Vesicle Stage

Improvement of oocyte quality through the SIRT signaling pathway

Contact Info

Product

Resources

About