In vitro leishmanicidal activity of monoterpenes present in two species of Protium (Burseraceae) on Leishmania amazonensis

Santana, Raissa Couto; Rosa, Alice dos Santos; Mateus, Michelle Hipólito da Silva; Soares, Deivid Costa; Atella, Geórgia C.; Guimarães, Anderson Cavalcante; Siani, Antônio Carlos; Ramos, Mônica Freiman de Souza; Saraiva, Elvira M.; Pinto-da-Silva, Lúcia Helena

doi:10.1016/j.jep.2020.112981

Cited by 22 publications

(14 citation statements)

References 48 publications

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“…E-caryophyllene, the main component of Melampodium divaricatum and Casearia sylvestris essential oil, has been reported for its promising antileishmanial response against L. amazonensis (IC 50 values of 10.7, 10.7, and 14.0 μg/ ml) (Moreira et al, 2019). Moreover, 1,8-cineole, α-pinene, and p-cymene active constituents of Protium altsonii and P. hebetatum (Burseraceae) exhibited dose-dependent amastigote inhibition with IC 50 of 48.4, 37, and 46 μg/ml, respectively (Santana et al, 2020). Butanol fraction of K. odoratissima with 154.1 μg/ml IC 50 value showed antileishmanial properties against L. major promastigote and amastigote (Mirzaei et al, 2020).…”

Section: Involvement Of Plant Extracts and Plant-derived Secondary Metabolitesmentioning

confidence: 99%

“…Hence, there is an instantaneous necessity to innovate new, harmless, and efficient prevention therapies to overcome these limitations (Mitropoulos et al, 2010). Currently, various approaches are involved to control the elevated level of infection, including nanoformulations and targeted drug delivery using nanocarriers as well as with the aid of particular bioactive compound obtained from plants (Javed et al, 2020;Santana et al, 2020). Inventions in nanoscience greatly contribute to overcome the problems allied with the treatment of infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

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Green Approach: ‘‘A Forwarding Step for Curing Leishmaniasis—A Neglected Tropical Disease’’

Sharma

Dhiman

Singh

et al. 2021

Front. Mol. Biosci.

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The present review focuses on a dreaded vector-mediated leishmaniasis, with the existing therapeutic approaches including a variety of drugs along with their limitations, the treatment with natural compounds, and different types of metal/metal oxide nanoparticles (NPs). As evidenced, various metallic NPs, comprising silver, silver oxide, gold, zinc oxide, titanium, lead oxide, etc., played a curative role to treat leishmaniasis, are also presented. Keeping in view the advance success of vaccines against the prevalent dreaded diseases in the past and the present scenario, efforts are also being made to develop vaccines based on these NP formulations.

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Section: Involvement Of Plant Extracts and Plant-derived Secondary Metabolitesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Green Approach: ‘‘A Forwarding Step for Curing Leishmaniasis—A Neglected Tropical Disease’’

Sharma

Dhiman

Singh

et al. 2021

Front. Mol. Biosci.

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“…Burseraceae é composta por 21 gêneros e ~700 espécies classificadas e divididas em três tribos: Protieae, Canarieae e Bursereae. Apresenta espécies com limbo foliar geralmente alterno e composto de margen inteira ou serreada, folíolos com pulvínulo, as inflorescencias ocorrem como racemos, panículas ou pseudo-espigas, sendo as flores unisexuadas e frutos deupáceos, às veces capsulares, muitoas veces oblíquos (DeCarlo et al, 2019;Santana et al, 2020).…”

Section: Introductionunclassified

Óleo essencial dos pecíolos de Protium ovatum Engl. (Burseraceae) apresenta atividade bioativa e antifúngica?

et al. 2022

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Protium ovatum é uma espécie vegetal presente nos mais variados tipos de Cerrado do Brasil, sendo esta espécie reconhecida como planta fitoterápica. O objetivo do estudo, foi caracterizar química e biologicamente os óleos essenciais de pecíolos de Protium ovatum coletados em três áreas do Cerrado no estado de Goiás, Brasil. Pecíolos foram coletados em três áreas do Cerrado. O óleo essencial foi extraído em Clevenger, sendo o rendimento determinado em porcentagem. As análises físico-químicas foram realizadas quanto à composição química por cromatografia gasosa com espectrometria de massas, densidade relativa, solubilidade, índice de refração e rotação óptica. Para determinar a atividade antioxidante biológica, foi utilizado o DPPH, determinado no CI50, e a atividade antifúngica foi realizada pela diluição do óleo essencial pelo método de difusão em disco. Os óleos essenciais apresentaram rendimento de 0,35; 0,44 e 0,29%, densidade 0,905; 0,907 e 0,912 g mL-1, solubilidade positiva, índice de refração de 1,3881; 1,3853 e 1,3799, rotação óptica de +40,6; +40,9 e +39,8 αD e CI50 de 1,67; 1,57 e 2,19 µL mL-1, para Cerradão, Cerrado rupestre e Campo sujo, respectivamente. Foram obtidos cerca de 12 compostos majoritários, e excepcional atividade antifúngica sobre as cepas de Candida. Os óleos essenciais apresentam-se como uma nova fonte antioxidante e antifúngica contra às cepas de Candidas. As características físico-químicas são semelhantes às de outros óleos essenciais da literatura. As características fitofisionômicas devem ser avaliadas futuramente por análise genética entre os grupos de indivíduos nas três áreas de estudo.

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“…Ramos et al (2000), with six species of Protium, showed that the essential oils of the resin had variable percentages of p-cymene (11.3-90%). Essential oils that are rich with high levels of α-pinene (42.9%) and p-cymene (33.3%) have shown potential against Leishmania (Santana et al, 2020). The resin from Protium with sesquiterpene as the predominant constituent are rare and Protium decandrum has been found to be rich in trans-α-bergamotene (47.7%) (Carvalho et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Characterization of essential oils from odoriferous resins of Amazonian species of Protium Burm. f.

Lima

Queiroz

Melo

et al. 2022

RSD

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The odoriferous resins produced by the trees of Protium spp (Burseraceae) are known in the Amazonian region as “breus” where they have been used to caulk canoes, as a mosquito repellent, and also have potential use in perfumery. Most species in this region have had the essential oils of their resins characterized, thus, the objective of this study was to evaluate for the first time the volatile constituents from the resin of Protium gallosum Daly, P. paniculatum Engl., P. pillosum (Cuatrec.) Daly and P. paniculatum var. riedelianum (Engl.) Daly. The samples from the individuals that had been previously identified were collected at the Adolpho Ducke Forest Reserve and subjected to hydrodistillation in a Clevenger apparatus, and the essential oils obtained were analyzed using GC-FID and GC-MS. The essential oil of P. gallosum showed high percentages of oxygenated monoterpenes (43.61%) with a predominance of terpin-4-ol (25.15%), and P. paniculatum consisted exclusively of monoterpenes that were predominantly p-cymene (43.52%; hydrocarbon monoterpene) and the 1,8-cineole (16.83%; oxygenated monoterpene). Most of the monoterpenes identified from P. pillosum and P. paniculatum var. riedelianum were hydrocarbons with a predominance of α-pinene, with 37.74% and 50.93%, respectively. 1,8-Cineole (21.89%) was also identified in the essential oil of P. pillosum. The results obtained this study add chemical knowledge to Burseraceae resins from a biological reserve of the Central Amazon.

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In vitro leishmanicidal activity of monoterpenes present in two species of Protium (Burseraceae) on Leishmania amazonensis

Cited by 22 publications

References 48 publications

Green Approach: ‘‘A Forwarding Step for Curing Leishmaniasis—A Neglected Tropical Disease’’

Green Approach: ‘‘A Forwarding Step for Curing Leishmaniasis—A Neglected Tropical Disease’’

Óleo essencial dos pecíolos de Protium ovatum Engl. (Burseraceae) apresenta atividade bioativa e antifúngica?

Characterization of essential oils from odoriferous resins of Amazonian species of Protium Burm. f.

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