In vitro interactions of malachite green and leucomalachite green with hepatic drug-metabolizing enzyme systems in the rainbow trout (Onchorhyncus mykiss)

Nebbia, Carlo; Girolami, Flavia; Carletti, Monica; Gasco, Laura; Zoccarato, Ivo; Albo, A. Giuliano

doi:10.1016/j.toxlet.2017.07.900

Cited by 8 publications

(4 citation statements)

References 39 publications

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“…The compound is also used in aquaculture to control parasites due to its antiprotozoal and antifungal properties [26]. Malachite green of high concentration or low concentration with longer exposure causes toxicity to mammals such as the internal organs damage, mutagenesis, carcinogenic effect and developmental abnormalities [23]. The jackfruit (Actocarpus heterophyllus) is also known as jack tree, which belongs to family Moraceae, native to South-West India [19].…”

Section: Introductionmentioning

confidence: 99%

Jackfruit leaf as an adsorbent of malachite green: recovery and reuse of the dye

Das

Mishra

2019

SN Appl. Sci.

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Dry leaf powder of jackfruit (Actocarpus heterophyllus) was utilized for the removal of an industrial dye malachite green from the aqueous solution by the batch adsorption method. The parameters which effect on adsorption such as adsorption dose, contact time between adsorbent and the dye in solution, and pH of the solution were studied and standardized. The scanning electron microscope (SEM) photography of the jackfruit leaf powder (JLP) indicated that it had a large number of pores, spaces and empty sites. The SEM photography of used JLP shows that the dye is confidently attached on the JLP. Fourier-transform infrared spectroscopy analysis of the adsorbent confirmed the presence of different functional groups like-OH,-NH and C=O on its surface, which can be correlated with the fine adherence of the dye on the surface of the adsorbent. Moreover, the shifting of the functional group on the surface of adsorbed adsorbents indicates the affinity of the dye towards the adsorbent. The Freundlich isotherm model with the correlation coefficient (r 2) value of 0.9880 is considered as a suitable absorption model for adsorption of dye. The pH of the aqueous solution was reduced from pH 7 to pH 5. This helped the recovery of the 80% of the attached dye. The present work concludes that jackfruit leaf powder can be used as an efficient adsorbent to remove malachite green from aqueous medium and the adsorbed dye can also be recovered for reuse from the surface of the adsorbent.

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Section: Introductionmentioning

confidence: 99%

Jackfruit leaf as an adsorbent of malachite green: recovery and reuse of the dye

Das

Mishra

2019

SN Appl. Sci.

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“…It has been shown that CYP1A-associated arylhydrocarbon hydroxylase activity increases with malachite green treatment in SHE primary cultures (Panandiker et al 1992). The results of in vitro study has reported that CYP1A-associated EROD activity decreases with the addition of increasing concentration of malachite green into the reaction medium (Nebbia et al 2017). However, there are contradictory reports about the effect of malachite green on CYP1A.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, the mRNA expression level of GST was inhibited signi cantly by the administration of 0.5 mg/L malachite green in Nile tilapia, grass carp, and Taiwan snakehead (Li et al 2011). The involvement of GST in the biotransformation of malachite green has been shown with in vitro inhibition studies (Nebbia et al 2017). However, the results of the current in vivo study clearly showed that this activity was not modulated by acute treatment of malachite green.…”

Section: Discussionmentioning

confidence: 99%

“…In vivo studies on the biotransformation reactions of malachite green is limited and contradictory results on the effect of malachite green have been reported in the literature. Nebbia et al (2017) reported the inhibitory effect of malachite green on GST and CYP1A enzyme activities with in vitro studies. In their study, they highlighted the necessity of in vivo studies to eventually con rm their in vitro results.…”

Section: Introductionmentioning

confidence: 99%

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In Vivo Modulatory Effect of Malachite Green on Cytochrome P450 and Antioxidant Enzyme Activities in Rainbow Trout Liver

Bozcaarmutlu-Büken,

Yıldırım,

Sapmaz

et al. 2024

Preprint

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Malachite green is a mutagenic and carcinogenic chemical used in textile and paper industry as a dye and fish farms against ectoparasites as well as bacteria and fungal infections. Aquatic organisms are under the risk of malachite green exposure. In this study, our aim was to determine the effect of two different doses of malachite green on cytochrome P450 system and antioxidant system in rainbow trout (Oncorhynchus mykiss). For this purpose, 24 fish were randomly divided into three groups namely control, 0.1 mg/L malachite green treatment group and 0.5 mg/L malachite green treatment group. Highly elevated 7-ethoxyresorufin-O-deethylase activities (EROD) were measured in fish treated with 0.5 mg/L malachite green. 7-pentoxyresorufin O-depentylase (PROD) activities increased with increasing doses of malachite green. Catalase (CAT) and glutathione reductase (GR) activities of 0.1 mg/L malachite green administration group were higher than that of the control group. Erythromycin N-demethylase (ERND) activities were higher in treatment groups than that of the control group. However, these differences in ERND activities were not statistically significant. Glutathione S-transferase (GST) activities were not affected from the malachite green treatment in both of the treatment groups. In this study, it is clear that malachite green has modulatory effect on EROD, PROD, CAT and GR activities in rainbow trout.

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Lethal and sublethal exposure of Hemichromis bimaculatus (Gill, 1862) to malachite green and possible implications for ornamental fish

Souza

Melo

Azevedo

et al. 2020

Environ Sci Pollut Res

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In vitro interactions of malachite green and leucomalachite green with hepatic drug-metabolizing enzyme systems in the rainbow trout (Onchorhyncus mykiss)

Cited by 8 publications

References 39 publications

Jackfruit leaf as an adsorbent of malachite green: recovery and reuse of the dye

Jackfruit leaf as an adsorbent of malachite green: recovery and reuse of the dye

In Vivo Modulatory Effect of Malachite Green on Cytochrome P450 and Antioxidant Enzyme Activities in Rainbow Trout Liver

Lethal and sublethal exposure of Hemichromis bimaculatus (Gill, 1862) to malachite green and possible implications for ornamental fish

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