In vitro interaction studies of diltiazem with H2 receptor antagonists

Abstract

Diltiazem is a well-known cardiovascular drug that is used clinically for the treatment of angina pectoris and hypertension. H 2 -receptor antagonists are used to treat gastroesophageal reflux, gastric and duodenal ulceration. In vitro interaction studies of diltiazem with H 2 -receptor antagonists (cimetidine, ranitidine, and famotidine) were investigated by using spectrophotometric and RP-HPLC techniques. The availability of diltiazem was found to be influenced considerably in presence of H 2 -receptor antagonists. The effect of various dissolution mediums, simulating body environments with respect to pH on these interactions was examined to elucidate the mechanism of these interactions. Moreover, diltiazem-H 2 receptor complexes were synthesized to confirm the interaction of these drugs. The complexes formed were then characterized by IR spectroscopy and verified by computational molecular modeling.

Evaluation of antiulcer activity of diltiazem in rats

“…12 Diltiazem is a calcium channel blocker of non-dihydropyridine type. 5 In present study, diltiazem has the property of ulcer preventing activity in diclofenac induced gastric ulcers. Different parameters in present study were used like number of gastric ulcers gives clear indication of ulcer inducing property of diclofenac and protective effect of diltiazem.…”

“…The pepsinogen activation by gastric acid activates the digestive process that kills bacteria, other microbes thus providing a stable gastric environment. 4,5 Calcium is critical for stimulus secretion coupling in gut as hypercalcaemia is associated with increased gastric acid secretion. There is calcium dependent release of Histamine, acetyl choline, gastrin and hydrochloric acid.…”

“…2,4 Diltiazem, well known cardiovascular drug that having calcium channel blocking property is used clinically for the treatment of hypertension and angina pectoris. 5 Diseases of gastrointestinal disorders and hypertension often coexists, therefore medicines for peptic ulcer diseases and hypertension need to be administered together for cure of gastrointestinal tract disorders and hypertension. 6 Thus a drug that can be used for both hypertension and peptic ulcer disease is the need of the hour.…”

A Validated Reverse Phase Liquid Chromatographic Method for Simultaneous Analysis of Enalapril Maleate, Hydrochlorothiazide and Furosemide in Active Pharmaceutical Ingredients, Pharmaceutical Dosage Forms and Human Serum

“…There are very few methods reported in literature for the simultaneous estimation of angiotensin II receptor antagonist and hydrochlorothiazide in tablets [18][19][20], though a simultaneous method for captopril and diuretics has also been developed and validated by [21]. Sultana et al (2007) have also studied the in vitro interactions of captopril H 2 -receptor antagonists [22]. However, no HPLC method for separation and simultaneous determination of enalapril and two different diuretics has been reported.…”

Investigation of Drug Interaction Studies of Levocetirizne with HMG-CoA Reductase Inhibitors

“…Before, our research group explored a number of drug-drug interactions of hypoglycemic agents [26], NSAIDs [27][28][29], statins [30], atenolol [31], NIDDM drugs [32] and H 2 -antagonists [33].…”