In vitro hemocompatibility and vascular endothelial cell functionality on titania nanostructures under static and dynamic conditions for improved coronary stenting applications

Mohan, Chandini C.; Chennazhi, K.P.; Menon, Deepthy

doi:10.1016/j.actbio.2013.08.023

Cited by 75 publications

(70 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Haemocompatibility assay is a major part of biocompatibility testing; this is an index of good blood compatibility and represents the evaluation of critical interactions of foreign material with blood [64]. The results for haemolysis rate are shown in Table 4.…”

Section: Haemolysis Assaymentioning

confidence: 99%

Enhancing antimicrobial activity of TiO2/Ti by torularhodin bioinspired surface modification

Ungureanu

Dumitriu

Popescu

et al. 2016

Bioelectrochemistry

View full text Add to dashboard Cite

Section: Haemolysis Assaymentioning

confidence: 99%

Enhancing antimicrobial activity of TiO2/Ti by torularhodin bioinspired surface modification

Ungureanu

Dumitriu

Popescu

et al. 2016

Bioelectrochemistry

View full text Add to dashboard Cite

“…12 Current research is focused on understanding the interaction of the blood and its components with material surfaces as well as developing surfaces that have toward favorable interactions with blood and its components. 13−15 The ability to regulate immune reactions on a material surface is vital for the success of any implantable biomedical device and also determines its hemocompatibility. To this day, there is no truly hemocompatible surface.…”

Section: Introductionmentioning

confidence: 99%

Improved in Vitro Blood Compatibility of Polycaprolactone Nanowire Surfaces

Leszczak

Popat

2014

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

There are a multitude of polymeric materials currently utilized to prepare a variety of blood-contacting implantable medical devices. These devices include tissue grafts, coronary artery and vascular stents, and orthopedic implants. The thrombogenic nature of such materials can cause serious complications in patients, and ultimately lead to functional failure. To date, there is no truly hemocompatible biomaterial surface. Nanostructured surfaces improve cellular interactions but there is a limited amount of information regarding their blood compatibility. In this study, the in vitro blood compatibility of four different surfaces (control, PCL; nanowire, NW; collagen immobilized control, cPCL; collagen immobilized nanowire, cNW) were investigated for their use as interfaces for blood-contacting implants. The results presented here indicate enhanced in vitro blood compatibility of nanowire surfaces compared control surfaces. Although there were no significant differences in leukocyte adhesion, there was a decrease in platelet adhesion on NW surfaces. Scanning electron microscopy images showed a decrease in platelet/leukocyte complexes on cNW surfaces and no apparent complexes were formed on NW surfaces compared to PCL and cPCL surfaces. The increase in these complexes likely contributed to a higher expression of specific markers for platelet and leukocyte activation on PCL and cPCL surfaces. No significant differences were found in contact and complement activation on any surface. Further, thrombin antithrombin complexes were significantly reduced on NW surfaces. A significant increase in hemolysis and fibrinogen adsorption was identified on PCL surfaces likely caused by its hydrophobic surface. This work shows the improved blood-compatibility of nanostructured surfaces, identifying this specific nanoarchitecture as a potential interface for promoting the long-term success of blood-contacting biomaterials.

show abstract

“…The crystalline titanium oxides had a slightly higher activation of the clotting cascade but lower platelet adhesion than nanocrystalline and amorphous titanium oxides. In addition, Mohan et al [73] reported that the relatively thicker TiO 2 layer (150-200 nm) obtained through hydrothermal processing in contrast to the native TiO 2 layer (5-10 nm) would probably provide improved hemocompatibility. The rough topography could result in increased surface area, which in turn could lead to increased plasma protein adsorption, and subsequently more platelet adhesion and activation [74].…”

Section: In Vitro Biocompatibility and Hemocompatibilitymentioning

confidence: 97%

Microstructure, mechanical properties, castability and in vitro biocompatibility of Ti–Bi alloys developed for dental applications

et al. 2015

View full text Add to dashboard Cite

In vitro hemocompatibility and vascular endothelial cell functionality on titania nanostructures under static and dynamic conditions for improved coronary stenting applications

Cited by 75 publications

References 35 publications

Enhancing antimicrobial activity of TiO2/Ti by torularhodin bioinspired surface modification

Enhancing antimicrobial activity of TiO2/Ti by torularhodin bioinspired surface modification

Improved in Vitro Blood Compatibility of Polycaprolactone Nanowire Surfaces

Microstructure, mechanical properties, castability and in vitro biocompatibility of Ti–Bi alloys developed for dental applications

Contact Info

Product

Resources

About