In vitro free radical scavenging activity of different extracts of Adansonia digitata L.

Talari, Samatha; Gundu, Chandrakala; Koila, Thirupathi; Nanna, Rama Swamy

doi:10.22161/ijeab/2.3.21

Cited by 8 publications

(9 citation statements)

References 12 publications

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“…Positive correlations between phenolic compound concentrations and antioxidant activity have been recorded by numerous researchers (Konan et al 2014). The in vitro antioxidant activity of A. digitata (baobab) was well documented previously by Talari et al (2017) and Braca et al (2018). According to the present data, helium-neon laser treatment for A. digitata stems and leaves at the power of 10 mW for 2 min (T2) increased concentrations of investigated polyphenol compounds including gallic acid, coffeic acid, kaempferol, luteolin, rutin, quercetin, naringenin, catechin, dihydroxyisoflavone, and cinnamic acid compared to extract from the untreated plant (T1).…”

Section: Discussionsupporting

confidence: 62%

Innovative application of helium-neon laser: enhancing the germination of Adansonia digitata and evaluating the hepatoprotective activities in mice

Khamis

Hassan

Morsy

et al. 2020

Environ Sci Pollut Res

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The laser pretreatment of seed is drawing pronounced attention from the scientific community for its positive impact in boosting germination, seedling, and growth of plants. In this study, the laser pretreatment of Adansonia digitata (A. digitata) seeds was evaluated. Eight laser treatments were conducted at different powers, 10, 20, 40, and 80 mW, with the two-time interval for each power at 2 and 4 min. The outcomes indicated that the most efficient irradiation was 10 mW/2 min which induces the highest germination rate and polyphenolic contents for seeds. Based on these results, the animal experimental design was processed to assess the hepatoprotective activity of A. digitata extracts obtained through the optimum laser preillumination to enhance the resistance of liver damage in mice. The total phenol and flavonoid contents and the antioxidant properties of the methanolic extracts were estimated in vitro. The CCl4 was used to induce hepatotoxicity in mice. The animals were divided into five groups. The sera of the treated animals were used for the determination of transaminases, and the liver homogenates were used for the determination of antioxidant status, and further liver tissues were subjected to verify the anti-apoptotic effect of A. digitata methanolic extract. The in vivo results showed that the methanolic extract exposed to laser treatment at 10 mW/2 min provided better hepatoprotective capacity than the other treatments. Administration of A. digitata extract not only offered a significant decrease in liver enzyme activity but also markedly improved the antioxidant status and reduced the apoptotic progression induced by CCl4 toxicity in liver tissue.

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Section: Discussionsupporting

confidence: 62%

Innovative application of helium-neon laser: enhancing the germination of Adansonia digitata and evaluating the hepatoprotective activities in mice

Khamis

Hassan

Morsy

et al. 2020

Environ Sci Pollut Res

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“…Besides, the leaves have an abundant amount of mucilage, carbohydrate (60-70%), protein (13-15%), fiber (11%), fat (4-10%), and minerals including calcium, iron, potassium, magnesium, phosphorous, zinc, and manganese [ 9 ]. Previously, Talari et al [ 10 ] had concluded that methanolic extract of various parts of the tree showed a strong free radical scavenging activity associated with their phytochemical constituents. This property raises the possibility that these methanolic extracts could be utilized in the preparation of antioxidant drugs for the treatment of a range of ailments [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Previously, Talari et al [ 10 ] had concluded that methanolic extract of various parts of the tree showed a strong free radical scavenging activity associated with their phytochemical constituents. This property raises the possibility that these methanolic extracts could be utilized in the preparation of antioxidant drugs for the treatment of a range of ailments [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of a Methanolic Extract of Adansonia digitata Leaf in Alleviating Hyperglycemia, Hyperlipidemia, and Oxidative Stress of Diabetic Rats

Ebaid

Bashandy

Alhazza

et al. 2019

BioMed Research International

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Traditionally, in many countries, various parts of the Adansonia digitata (A. digitata) tree have been used in the treatment of many clinical ailments including diarrhea and dysentery. The phytochemical screening has indicated that the leaf extract of A. digitata contains flavonoids, saponins, mucilage, steroids, and alkaloids. Thus, this paper aims to evaluate the hyperglycaemic and hypolipidaemic effects of methanolic extract of A. digitata leaves (200 mg/kg and 400 mg/kg) in diabetic rats. The extract was administered orally for six weeks in the streptozotocin (STZ)-induced diabetic rats. The treatment with the extract caused a significant reduction in the blood glucose, glycosylated hemoglobin, cholesterol, triglycerides, low-density lipoprotein (LDL), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), and malondialdehyde (MDA) levels by 46.7%, 46.15%, 48.91%, 43%, 60%, 66%, 45.45%, and 30.4%, respectively, as compared to the diabetic group after the sixth week of treatment. The leaf extract also mitigated the decline of high-density lipoprotein (HDL) level, RBCs count, hemoglobin level, packed cell volume (PCV %), and erythropoietin concentration in diabetic rats by 31%, 33.25%, 24.72%, 51.42%, and 220.68% with respect to the diabetic group. Also, the extract maintained the level of antioxidant enzymes, catalase (CAT) and superoxide dismutase (SOD), and reduced glutathione (GSH) in the diabetic rats. It also reduced the elevation in the white blood corpuscles (WBC) count in the STZ-induced diabetic rats. Our study, therefore, indicates that methanolic extract of A. digitata leaf exerts strong antidiabetic and hypolipidaemic properties in a dose-dependent manner by improving the hematological properties and redox parameters in the experimental diabetic rats.

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“…The methanolic fruit pulp and leaf extracts of A. digitata exhibited in vitro antioxidant activities as studied by 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH), 2,2-azinobis—(3-ethylbenzothiazoline-6-sulfonate) (ABTS), ferric reducing antioxidant power (FRAP), β-carotene bleaching test, superoxide-scavenging assays [ 50 , 150 ]. The methanol extracts of leaf, seed, bark, fruit wall, and floral extracts of A. digitata were reported for their DPPH scavenging potential [ 147 ]. The DPPH scavenging activity was highest in seed extract (27.69%) and lowest in fruit wall (20.69%) extract.…”

Section: Pharmacological Potential Of Bombacoideaementioning

confidence: 99%

Systematics, Phytochemistry, Biological Activities and Health Promoting Effects of the Plants from the Subfamily Bombacoideae (Family Malvaceae)

Das

Shin

Ningthoujam³

et al. 2021

Plants

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Plants belonging to the subfamily Bombacoideae (family Malvaceae) consist of about 304 species, many of them having high economical and medicinal properties. In the past, this plant group was put under Bombacaceae; however, modern molecular and phytochemical findings supported the group as a subfamily of Malvaceae. A detailed search on the number of publications related to the Bombacoideae subfamily was carried out in databases like PubMed and Science Direct using various keywords. Most of the plants in the group are perennial tall trees usually with swollen tree trunks, brightly colored flowers, and large branches. Various plant parts ranging from leaves to seeds to stems of several species are also used as food and fibers in many countries. Members of Bombacoides are used as ornamentals and economic utilities, various plants are used in traditional medication systems for their anti-inflammatory, astringent, stimulant, antipyretic, microbial, analgesic, and diuretic effects. Several phytochemicals, both polar and non-polar compounds, have been detected in this plant group supporting evidence of their medicinal and nutritional uses. The present review provides comprehensive taxonomic, ethno-pharmacological, economic, food and phytochemical properties of the subfamily Bombacoideae.

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In vitro free radical scavenging activity of different extracts of Adansonia digitata L.

Abstract: Abstract- (27.69 & 20) as measured by using DPPH assay. These results showed the antioxidant potential of this medicinal plant to make use in the preparation of drugs with free radical scavenging activity.

Cited by 8 publications

References 12 publications

Innovative application of helium-neon laser: enhancing the germination of Adansonia digitata and evaluating the hepatoprotective activities in mice

Innovative application of helium-neon laser: enhancing the germination of Adansonia digitata and evaluating the hepatoprotective activities in mice

Efficacy of a Methanolic Extract of Adansonia digitata Leaf in Alleviating Hyperglycemia, Hyperlipidemia, and Oxidative Stress of Diabetic Rats

Systematics, Phytochemistry, Biological Activities and Health Promoting Effects of the Plants from the Subfamily Bombacoideae (Family Malvaceae)

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