In vitro fertilization when men, women, or both partners are positive for HIV: a case–control study

Vankerkem, Pauline; Manigart, Yannick; Delvigne, Annick; Ameye, Lieveke; Konopnicki, Déborah; Shaw-Jackson, Chloë; Rozenberg, Serge; Autin, Candice

doi:10.1007/s00404-017-4374-0

Cited by 13 publications

(13 citation statements)

References 29 publications

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“…In the ''women HIV'' group, implantation rate, clinical pregnancy rate (by transfer and by oocyte retrieval), and live birth rate (by transfer) were significantly lower compared with those of controls. In 2017, Vankerkem et al (20) found similar results in a case-control study (higher cancellation rate, lower number of oocytes, and lower clinical transfer rate and oocyte retrieval rate in the ''women HIV'' group).…”

Section: Discussionmentioning

confidence: 73%

“…In their 2011 study, Santulli et al ( 18) had higher cancellation rates and significantly lower clinical pregnancy rates by oocyte retrieval in HIV-infected female and male couples vs. controls. In 2017, Vankerkem et al (20) did not show any significant difference in the outcome of HIV couples compared with HIV-negative controls. However, a negative trend was found for HIV couples with a live birth rate of 3% vs. 12% in the control group (P ¼ .3) and an evolutionary clinical pregnancy rate per transfer of 5% vs. 15% in the control group (P ¼ .28).…”

Section: Discussionmentioning

confidence: 94%

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Comparison of in vitro fertilization cycles in couples with human immunodeficiency virus type 1 infection versus noninfected couples through a retrospective matched case-control study

et al. 2021

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 94%

Comparison of in vitro fertilization cycles in couples with human immunodeficiency virus type 1 infection versus noninfected couples through a retrospective matched case-control study

et al. 2021

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“…Several studies are reported in literature, investigating the clinical outcomes of HIV‐ or HCV‐seropositive men, but very few with a case–control study design. Some authors believed that male HIV infection has no effect on fertilization, implantation, pregnancy and live birth rates (Melo et al ., ; Yang et al ., ; Vankerkem et al ., ). Equally, two out of the three matched control studies in literature did not find differences in clinical pregnancy rates (Santulli et al ., ; Prisant et al ., ), whereas the third one detected higher rates of FR and PR/C for cases involving HIV‐positive men (Kashima et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Influence of male human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection on the reproductive outcomes in serodiscordant couples: a case–control study

et al. 2019

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Background: Nowadays, serodiscordant couples (SDCs) with human immunodeficiency virus (HIV) or hepatitis C virus (HCV)infected men have the chance to conceive safely, giving birth with a minimum risk of cross-infection. Objective: To assess the impact of male HIV and HCV infection on the assisted reproductive technologies (ART) outcomes in SDCs, with HIV or HCV seropositive men and negative partners. Materials and methods: Of 153 couples: 24 in Group 1 (HIV-seropositive men), 60 in Group 2 (HCV-seropositive men) and 69 in Group 3 (controls). Sperm-washing procedure was performed using a three-step system. Fresh ICSI cycles were carried out in HIV SDCs, HCV SDCs and controls. Seminal parameters, fertilization rate (FR), cleavage rate (CR), pregnancy rate per cycle (PR/C), miscarriage rate, implantation rate (IR) and live birth rate were evaluated. Results: All the seropositive men have undetectable viral loads at the time of insemination, and both partners were free from comorbid infections. The median number of embryos transferred was 2.0 (IQR 1.0-3.0), with no differences among groups. FR was significantly reduced in HIV and HCV SDCs compared to the controls (66%, 61% and 75%, respectively; p < 0.01). CR was similar between groups (p = 0.3). IR was 12.1%, 11.1% and 14.1%, respectively, in the three groups (p = 0.30). PR/C was 21.7%, 17.6% and 20.2% in HIV, HCV and controls, respectively. Live birth rate per cycle was 17.4%, 15.7% and 15.9%, respectively. There were no significant differences in clinical pregnancies per cycle, as well as miscarriages and live births (p = 0.30; 0.30; 0.60, respectively). Conclusions: The sperm-washing technique with ICSI may generate a promising way to improve pregnancy outcomes and to reduce the risk of viral transmission in these couples. In this setting, we can correctly counsel HIV-and HCV-infected men of SDCs with regard to the likelihood of father their own biological child.

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“…[24][25][26]. Показательными являются доказанные сведения о повреждающем действии на клетку АРТ, применяемой при лечении ВИЧ-инфицированных пациенток [11,12]. Известно, что операции на яичниках значительно снижают овариальный резерв [13,14].…”

Section: вспомогательные репродуктивные технологии Assisted Reproductunclassified

Clinical characteristics of patients with violation of the early embryogenesis in IVF programs

Nazarenko¹,

Krasnopolskaya²,

Sesina³

et al. 2019

Probl. reprod.

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лечения бесплодия ЭКО» (ген. директор-проф. В.М. Здановский), Москва, Россия РЕЗЮМЕ Цель исследования-установить клинико-анамнестические характеристики пациенток, сопряженные с нарушениями эмбриологических показателей при проведении программ ЭКО. Материал и методы. Обследованы 80 женщин, проходящих лечение бесплодия методом ЭКО. Группу исследования составили 50 пациенток, имеющих нарушения раннего эмбриогенеза, когда не менее чем в 2 попытках лечения не оказалось эмбрионов, пригодных для переноса, группу контроля-30 женщин с хорошими показателями эмбриогенеза. Результаты. Продемонстрирован ряд достоверных различий между группой исследования и контроля: первичное бесплодие в группе исследования-62%, в группе контроля-36,7%, длительность бесплодия-6±2 и 2,6±1,5 года соответственно. Риск получения плохих эмбрионов в 4,8 раза выше при дефиците (ИМТ<19 кг/м 2) массы тела ОР=4,8 95% ДИ (0,63-36,51). Достоверные различия выявлены в структуре причин бесплодия, которая оказалась традиционной в группе контроля: трубноперитонеальный фактор-60%, эндокринный-3,3%, ассоциированный с эндометриоидными кистами яичников-10%, сочетанный-20%, неясного генеза-6,7%. У пациенток группы исследования причины бесплодия кардинально различались-неясного генеза-32%, эндокринного генеза-18%, эндометриоз яичников-14%, сочетанный-10%. В группе исследования в 2,5-5 раз чаще встречались операции на яичниках, в том числе двусторонние и повторные резекции. Выводы. Неблагоприятные показатели раннего эмбриогенеза и отсутствие эмбрионов, пригодных для переноса в неоднократных попытках ЭКО у молодых женщин, ассоциированы с первичным бесплодием неясного генеза, эндокринно-метаболическими нарушениями, низкой массой тела, повторными операциями на яичниках и длительным периодом бесплодия. Ключевые слова: нарушение раннего эмбриогенеза, бесплодие, ЭКО. ИНФОРМАЦИЯ ОБ АВТОРАХ Т.А. Назаренко-д.м.н., проф., ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова» Минздрава России, директор научно-образовательного центра вспомогательных репродуктивных технологий Фредерика-Паулсена-старшего (НОЦ ВРТ им. Ф. Паулсена), Москва ул.

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In vitro fertilization when men, women, or both partners are positive for HIV: a case–control study

Cited by 13 publications

References 29 publications

Comparison of in vitro fertilization cycles in couples with human immunodeficiency virus type 1 infection versus noninfected couples through a retrospective matched case-control study

Comparison of in vitro fertilization cycles in couples with human immunodeficiency virus type 1 infection versus noninfected couples through a retrospective matched case-control study

Influence of male human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection on the reproductive outcomes in serodiscordant couples: a case–control study

Clinical characteristics of patients with violation of the early embryogenesis in IVF programs

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