In vitro fertilization and risk of childhood leukemia in Greece and Sweden

Petridou, Eleni; Sergentanis, Theodoros N.; Panagopoulou, Paraskevi; Moschovi, Maria; Polychronopoulou, Sophia; Baka, Margarita; Pourtsidis, Apostolos; Athanassiadou, Fani; Kalmanti, Maria; Sidi, V.; Dessypris, Nick; Frangakis, Constantine; Matsoukis, Ioannis; Stefanadis, Christodoulos; Skalkidou, Alkistis; Stephansson, Olof; Adami, Hans Olov; Kieler, Helle

doi:10.1002/pbc.23194

Cited by 64 publications

(65 citation statements)

References 45 publications

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“…The results suggest that IVF is associated with increased risk of early onset acute lymphoblastic leukemia (ALL) in the offspring. Increased risk of leukemia was observed with 3.8 years earlier in IVF offspring than in the control (OR 2.21, 95% CI 1.27-3.85) (Petridou et al, 2012). Meanwhile, a moderately increased risk of cancer in IVF children (RR 1.42, 95% CI 1.09-1.87) has also been observed by Källén B. et al (2010a) through a follow-up study of 26 692 children who were born after ART between 1982 and2005. In brief, the evidence of cancer risk in children after ART is still very limited.…”

Section: Risk For Cancermentioning

confidence: 92%

Long-term follow-up of children conceived through assisted reproductive technology

Wang

Jin

2013

J. Zhejiang Univ. Sci. B

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Children conceived via assisted reproductive technologies (ART) are nowadays a substantial proportion of the population. It is important to follow up these children and evaluate whether they have elevated health risks compared to naturally conceived (NC) children. In recent years there has been a lot of work in this field. This review will summarize what is known about the health of ART-conceived children, encompassing neonatal outcomes, birth defects, growth and gonadal developments, physical health, neurological and neurodevelopmental outcomes, psychosocial developments, risk for cancer, and epigenetic abnormalities. Most of the children conceived after ART are normal. However, there is increasing evidence that ART-conceived children are at higher risk of poor perinatal outcome, birth defects, and epigenetic disorders, and the mechanism(s) leading to these changes have not been elucidated. Continuous follow-up of children after ART is of great importance as they progress through adolescence into adulthood, and new ART techniques are constantly being introduced.

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Section: Risk For Cancermentioning

confidence: 92%

Long-term follow-up of children conceived through assisted reproductive technology

Wang

Jin

2013

J. Zhejiang Univ. Sci. B

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“…Thus, fertility drugs, assisted reproductive technologies (ART), which involve further manipulation of the gametes, infertility itself through ovulation disorders, functional abnormalities and hormonal imbalances may be associated with CL risk. A few previous published studies reported positive associations between CL, infertility [8,9] and some fertility treatments [8,[10][11][12], albeit with inconsistency regarding the type of treatment. Petridou et al [12], reported a twofold increase in risk with in vitro fertilization (IVF), but the finding was not replicated by Rudant et al [8] in the ESCALE study or in a recent UK cohort study [13].…”

Section: Introductionmentioning

confidence: 93%

“…A few previous published studies reported positive associations between CL, infertility [8,9] and some fertility treatments [8,[10][11][12], albeit with inconsistency regarding the type of treatment. Petridou et al [12], reported a twofold increase in risk with in vitro fertilization (IVF), but the finding was not replicated by Rudant et al [8] in the ESCALE study or in a recent UK cohort study [13]. On the contrary, the ESCALE study showed an association between CL and ovulation induction without IVF or artificial insemination (AI), suggesting a role of drugs other than gonadotropins.…”

Section: Introductionmentioning

confidence: 93%

Maternal reproductive history, fertility treatments and folic acid supplementation in the risk of childhood acute leukemia: the ESTELLE Study

Ajrouche

Rudant

Orsi

et al. 2014

Cancer Causes Control

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“…(An increased incidence in early childhood leukemias for products of in vitro fertilization has been reported. 1 ) The spleen was palpable down to the pelvis and 3 cm across the midline. Results of the complete blood count and differential showed white blood cell (WBC) count 335 ϫ 10 3 /L with 17% neutrophils, 18% bands, 6% eosinophils, 5% basophils, 19% metamyelocytes, 8% myelocytes, 1% promyelocytes, 6% blasts, 5% monocytes, 14% lymphocytes, and 4% nucleated red blood cells, hemoglobin 6.2 g/dL, and platelets 713 ϫ 10 3 /L.…”

Section: Introductionmentioning

confidence: 99%

How I treat childhood CML

Andolina

Neudorf

Corey

2012

Blood

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Chronic myeloid leukemia (CML) is composed of 3% of pediatric leukemias, making evidence-based recommendations difficult. Imatinib has revolutionized the treatment for adult CML by eliminating allogeneic stem cell transplantation for almost all patients in chronic phase. Shown effective in pediatric CML, imatinib and successive tyrosine kinase inhibitors (TKI) have provided more therapeutic options. Because stem cell transplantation has been better tolerated in children and adolescents, the decision to treat by either TKI or transplantation is controversial. We present a recent case of a 12-month-old boy diagnosed with BCR-ABL ؉ CML to highlight the controversies in treatment recommendations. We review the pediatric stem cell transplantation outcomes as well as the pediatric experience with imatinib and other TKIs. Finally, we compare the side effects as well as costs associated with allogeneic stem cell transplantation versus TKI therapy. We recommend that frontline therapy for pediatric CML in chronic phase is TKI therapy without transplantation. Patients in accelerated or blast crisis or who fail to reach landmarks on TKIs either because of intolerance or resistance should pursue stem cell transplantation. Although we recommend adopting adult clinical experience to guide therapeutic decision making, the issues of infant CML, drug formulation, pharmacokinetics, and adolescent compliance merit clinical investigation.

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In vitro fertilization and risk of childhood leukemia in Greece and Sweden

Abstract: IVF seems to be associated with increased risk of early onset ALL in the offspring.

Cited by 64 publications

References 45 publications

Long-term follow-up of children conceived through assisted reproductive technology

Long-term follow-up of children conceived through assisted reproductive technology

Maternal reproductive history, fertility treatments and folic acid supplementation in the risk of childhood acute leukemia: the ESTELLE Study

How I treat childhood CML

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