In vitro examination of suspicious oral lesions using optical coherence tomography

Jerjes, Waseem; Upile, Tahwinder; Conn, Brendan; Hamdoon, Zaid; Betz, Christian; McKenzie, Gordon; Radhi, Hani; Vourvachis, M.; Maaytah, Mohammed El; Sandison, Ann; Jay, Amrita; Hopper, Colin

doi:10.1016/j.bjoms.2009.04.019

Cited by 73 publications

(51 citation statements)

References 24 publications

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“…Clearly, the ability of OCT to generate useful noninvasive information to detect epithelial abnormalities would be invaluable as many studies attest. 4,6,[23][24][25] However, at present, the level of discrimination obtained with OCT in skin and oral mucosa remains close to being useful but falls short of something that could be routinely used for this purpose in vitro or in vivo.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the use of optical coherence tomography for the detection of epithelial cancers in vitro

Smith

Hearnden

et al. 2011

J. Biomed. Opt.

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Abstract. Optical coherence tomography (OCT) is a noninvasive imaging methodology that is able to image tissue to depths of over 1 mm. Many epithelial conditions, such as melanoma and oral cancers, require an invasive biopsy for diagnosis. A noninvasive, real-time, point of care method of imaging depth-resolved epithelial structure could greatly improve early diagnosis and long-term monitoring in patients. Here, we have used tissue-engineered (TE) models of normal skin and oral mucosa to generate models of melanoma and oral cancer. We have used these to determine the ability of OCT to image epithelial differences in vitro. We report that while in vivo OCT gives reasonable depth information for both skin and oral mucosa, in vitro the information provided is less detailed but still useful. OCT can provide reassurance on the development of TE models of skin and oral mucosa as they develop in vitro. OCT was able to detect the gross alteration in the epithelium of skin and mucosal models generated with malignant cell lines but was less able to detect alteration in the epithelium of TE models that mimicked oral dysplasia or, in models where tumor cells had penetrated into the dermis. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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Section: Discussionmentioning

confidence: 99%

Evaluating the use of optical coherence tomography for the detection of epithelial cancers in vitro

Smith

Hearnden

et al. 2011

J. Biomed. Opt.

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“…Compared with the histopathological analysis of oral lesions, studies found optical tomography to be good at identifying diseased areas; however, it is poor at providing an actual diagnosis or at differentiating between lesions (Jerjes et al, 2010). Recent research found that delivery of gold nanoparticles to oral lesion sites enhanced in vivo optical tomography images of oral dysplasia; however, this was an animal study and further research in this field is therefore needed (Kim et al, 2009).…”

Section: Optical Tomographymentioning

confidence: 97%

“…Optical tomography is an imaging technique which uses the principles of ultrasound to examine subsurface reflections on tissue and produce a three-dimensional image to micrometre resolutions (Jerjes et al, 2010). Compared with the histopathological analysis of oral lesions, studies found optical tomography to be good at identifying diseased areas; however, it is poor at providing an actual diagnosis or at differentiating between lesions (Jerjes et al, 2010).…”

Section: Optical Tomographymentioning

confidence: 99%

Textbook of Plastic and Reconstructive Surgery

Butler¹,

Ghali²,

Kalaskar³

2016

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A CIP catalogue record for this book is available from The British Library.This book is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. The user is advised to always check the product information and clinical procedures with the most up-to-date published product information and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or misuse or misapplication of material in this work.ISBN: 978-1-910634-37-0 (Hbk.) ISBN: 978-1-910634-38-7 (Pbk.) ISBN: 978-1-910634-39-4 (PDF) ISBN: 978-1-910634-40-0 (epub) ISBN: 978-1-910634-41-7 (mobi)

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“…In a study of 50 patients with suspicious lesions, including oral leukoplakia and erythroplakia, the sensitivity and specificity of OCT were 93-97%, showing the excellent capability of in vivo OCT for the detection and diagnosis of oral PMDs and oral cancer (Wilder-Smith et al 2009). In another ex vivo study, Jerjes et al (2010) confirmed the feasibility of using OCT to identify architectural changes in an abnormal lesion area; unfortunately, it was unable to provide a diagnosis or to differentiate between lesions. Moreover, there are still limitations regarding the application of OCT: (1) a histopathologist is needed to interpret the result, which is subjective, as OCT does not provide quantitative information; (2) only a small area can be examined at a time, because of the small size of the OCT probe (Olivo et al 2011).…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

Non-Invasive Techniques for Detection and Diagnosis of Oral Potentially Malignant Disorders

Liu

Zhao

Zeng

et al. 2016

Tohoku J. Exp. Med.

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Oral squamous cell carcinoma (OSCC) is the most common oral and maxillofacial malignancy, and its morbidity and mortality rates are still high in most countries. Oral potentially malignant disorders (PMDs) are used to refer to a heterogeneous group of conditions that are characterized by increased risk for malignant transformation to OSCC. Currently identified oral PMDs include leukoplakia, erythroplakia, palatal lesions associated with reverse smoking, oral lichen planus, oral submucous fibrosis, actinic keratosis, and discoid lupus erythematosus. The early detection and diagnosis of these lesions are important for cancer prevention and disease management. In recent years, there has been a growing and persistent demand for new non-invasive, practical diagnostic techniques that might facilitate the early detection of oral PMDs. The non-invasive detection techniques evaluated in this review are divided into four categories: vital staining with a solution that can be used as a mouth rinse or applied onto a suspected area of the mouth, light-based detection systems, optical diagnostic technologies that employ returned optical signals to reflect structural and morphological changes within tissues, and salivary biomarkers. Most of these techniques have shown great potential for screening and monitoring oral PMDs. In this review article, the authors critically assess these non-invasive detection techniques for oral PMDs. We also provide a summary of the sensitivity and specificity of each technique in detecting oral PMDs and oral cancer, as well as their advantages, disadvantages, clinical applications, and indications.

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In vitro examination of suspicious oral lesions using optical coherence tomography

Cited by 73 publications

References 24 publications

Evaluating the use of optical coherence tomography for the detection of epithelial cancers in vitro

Evaluating the use of optical coherence tomography for the detection of epithelial cancers in vitro

Textbook of Plastic and Reconstructive Surgery

Non-Invasive Techniques for Detection and Diagnosis of Oral Potentially Malignant Disorders

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