In-vitro-Evaluierung der MR-Thermometrie zum Einsatz der laserinduzierten Thermotherapie

Vogl, Thomas; Mg, Mack; Hirsch, Hans H.; Müller, P.; Weinhold, Niels; Wust, Peter; Philipp, C.; Roggan, A.; Felix, R

doi:10.1055/s-2007-1015595

Cited by 21 publications

(4 citation statements)

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“…A specially-designed laser applicator delivers the energy of the Nd:YAG laser through a thin optical fibre to the target area to produce a well-defined necrosis and minimal damage of the surrounding structures [14,151. A variety of different sequences have been described and evaluated for MR-thermometry [7,8,11,[17][18][19][20][21][22]. Thermosensitive MR sequences are used to control the progress of the induced coagulation in relation to surrounding structures, such as vessels or nerves [9-11, 16, 171.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the temperature sensitivity of specially designed MR-sequences can be used to monitor temperature elevation in the tumour and surrounding normal tissues [7][8][9][10][11], thus increasing safety. The use of MRI offers optimal soft tissue contrast and the possibility of multiplanar imaging, which is essential for optimal evaluation of the turnours, as well as treatment guidance.…”

Section: Introductionmentioning

confidence: 99%

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Laser-induced thermoablation of tumours of the head and neck under MR tomographic control

Mack

Vogl

Eichler

et al. 1998

Minimally Invasive Therapy & Allied Technologies

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This study evaluates the potential of MR-guided laser-induced thermotherapy for the treatment of recurrent head and neck tumours, as a stand-alone method, or in combination with radiotherapy. 15 patients with recurrent head and neck tumours (recurrent squamous cell carcinoma n = l 3 , recurrent pleomorphic adenorna n=2) were treated, using MR-controlled laser-induced thermotherapy. 18 lesions were treated with 25 laser applications. MR thermometry was performed, using a temperature-sensitive TurboFLASH (TR/TE/TI = 7/3/400; flip angle = 8") and FLASH-2D (TR/TE/flip angle = 102/8/70") sequence for monitoring thermal-induced changes in signal and morphology. T, weighted (TRTCE=700/15) sequences, plain and contrast-enhanced, were used for follow-up. 14 patients tolerated the procedure well. In one patient, with a recurrent squamous cell carcinoma and infiltration of the sublingual gland, the treatment had to be stopped after 5 min due to pain. No long-term side effects related to treatment were observed. We were able to induce coagulative necrosis in all patients. The 4 year MR-control study of one patient with a pleomorphic adenoma showed no recurrent tumour. Clinically-relevant improvement of symptoms was observed in 1 1 patients. MRguided L l n is an excellent method of treating a local tumour recurrence in the head and neck region. MRthermometry allowed monitoring of laser-induced heating during LIT.Keywords recurrent head and neck cancer, laser induced interstitial thermotherapy (LIT), MR-guided interventions, minimal invasive therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Laser-induced thermoablation of tumours of the head and neck under MR tomographic control

Mack

Vogl

Eichler

et al. 1998

Minimally Invasive Therapy & Allied Technologies

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show abstract

“…First, MR imaging provides unparalleled topographic accuracy because of its excellent soft tissue contrast and high spatial resolution. Second, the temperature sensitivity of specially designed MR sequences can be used to monitor the temperature elevation in the tumor and surrounding normal tissue, [6][7][8][9][10][11] increasing safety. On-line MR imaging during LITT thus allows early detection of local complications and treatment effects such as bleeding, hemorrhage, or necrosis.…”

Section: Interstitialmentioning

confidence: 99%

Magnetic Resonance-Guided Laser-Induced Thermotherapy of Recurrent Head and Neck Tumors

Mack¹,

Vogl²

1999

Semin intervent Radiol

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“…A specially designed laser applicator delivers the energy of the Nd:YAG laser through a thin optical fiber to the target area in order to produce a well-defined necrosis and minimal damage of the surrounding structures [2,4]. Magnetic resonance imaging (MRI) has shown to be an ideal clinical instrument for exact positioning of the optical fibers in the tumor [5][6][7][8][9]. For real-time monitoring of the hyperthermic process during the laser treatment, thermosensitive MR sequences are used to control the progress of the induced coagulation in relation to surrounding structures such as vessels or nerves.…”

Section: Introductionmentioning

confidence: 99%

MR-Guided Laser-Induced Thermotherapy of Malignant Liver Lesions: Technique and Results

Vogl¹,

Mack²,

Straub³

et al. 1998

Oncol Res Treat

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Background: In order to improve the clinical outcome and survival time, patients with hepatic metastases of different primary tumors were treated with minimally invasive per-cutaneous MR-guided laser-induced thermotherapy (LITT). Material and Methods: All procedures were performed under local anesthesia. All lesions (n =733) were punctured under CT guidance. MR-guided LITT was performed using specially designed MR thermosequences for monitoring the treatment and a Nd:YAG laser device with a wavelength of 1,064 nm for energy application. This setup allowed an induction of precise coagulative necrosis and avoided larger damage of surrounding tissue. A total of 1,822 laser applications was performed. Results: 251 consecutive patients were included. All patients well tolerated the intervention under local anesthesia. The mean survival time, calculated using the Kaplan-Meier method, was 40.8 months for the whole patient series (median: 40.97 months, 95% CI 36.37–45.24 months) and 38.11 months (median 36.43 months, 95% CI 33.05–43.16 months) for patients affected by colorectal metastases. Conclusions: MR-guided LITT proved to be a safe and effective palliative treatment option for local destruction of liver metastases.

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In-vitro-Evaluierung der MR-Thermometrie zum Einsatz der laserinduzierten Thermotherapie

Abstract: MR-thermometry using sequentially TurboFLASH and FLASH-2D sequences allowed a non-invasive monitoring of the laser induced temperature changes.

Cited by 21 publications

References 0 publications

Laser-induced thermoablation of tumours of the head and neck under MR tomographic control

Laser-induced thermoablation of tumours of the head and neck under MR tomographic control

Magnetic Resonance-Guided Laser-Induced Thermotherapy of Recurrent Head and Neck Tumors

MR-Guided Laser-Induced Thermotherapy of Malignant Liver Lesions: Technique and Results

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