In vitro evaluation of the schistosomicidal effect of the extracts, fractions and major 3-hydroxy-2,6-dialkyl-substituted piperidine alkaloids from the flowers of Senna spectabilis (Fabaceae)

Castro, Andreísa Teixeira de; Castro, Aline Pereira; Silva, Matheus Siqueira; Souza, Isabella Maria Monteiro de; Martins-Souza, Raquel Lopes; Chagas‐Paula, Daniela Aparecida; Coelho, Luiz Felipe Leomil; Bolzani, Vanderlan da Silva; Pivatto, Marcos; Viegas, Cláudio; Marques, Marcos José

doi:10.1016/j.bmcl.2016.07.058

Cited by 12 publications

(6 citation statements)

References 53 publications

(57 reference statements)

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“…Although PZQ is not used to eliminate snail breeding cercariae, this compound was used during the present study as positive control. In agreement with other reports, PZQ causes 100% mortality of S. mansoni and S. japonicum cercariae at concentrations of 1, 8 and 12.5 μg mL −1 between 0.30 and 3 h …”

Section: Discussionsupporting

confidence: 92%

“…48 Although PZQ is not used to eliminate snail breeding cercariae, this compound was used during the present study as positive control. In agreement with other reports, PZQ causes 100% mortality of S. mansoni and S. japonicum cercariae at concentrations of 1, 8 and 12.5 μg mL −1 between 0.30 and 3 h. 30,36,49 CUR toxicity related to other environment organisms was not evaluated in this study; however, CUR showed no toxic effect and systemic abnormalities in a higher dose (1.5 mg) against Labeo rohita fish. 40 A human study demonstrated that CUR is safe at a 2.5 g per day dose.…”

Section: Discussionsupporting

confidence: 91%

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Molluscicidal and cercaricidal activities of curcumin on Biomphalaria glabrata and Schistosoma mansoni cercariae

Matos

Silva

Paula

et al. 2019

Pest Management Science

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BACKGROUND Schistosomiasis control in endemic areas depends on several factors, including chemotherapy, snail control and adequate sanitation. In this context, the employment of compounds isolated from plants is an important issue regarding infection and snail control. The aim of this study was therefore to evaluate the effects of curcumin (CUR), a compound isolated from Curcuma longa, against snails and embryos of Biomphalaria glabrata, which is the most important intermediate host of schistosomiasis in the Americas, as well as in cercariae, the infecting larval stage of Schistosoma mansoni. RESULTS CUR presented high activity against B. glabrata embryos and moderate activity against newborn and adult snails. The lethal concentration (LC50) values after being exposed for 24 h and evaluated for 7 days were 6.54 (95% confidence interval (CI) 5.86–7.30) μg mL−1 for the embryos and 42.29 (95% CI 33.82–52.87) μg mL−1 and 87.69 (95% CI 68.82–111.7) μg mL−1 for the newborn and adult snails, respectively. Moreover, CUR inhibited the development of embryos and egg hatching, and decreased the fecundity rates of adult snails. CUR also demonstrated cercaricidal activity with LC50 values lower than 10 μg mL−1 at 1, 3, 6, 9 and 12 h, respectively. CONCLUSION Our data show that CUR has potential molluscicidal and cercaricidal activities. Moreover, as a nutraceutical compound that is toxic to both invertebrate host and parasite, CUR has the potential to be explored as a safe new agent to combat schistosomiasis. © 2019 Society of Chemical Industry

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Molluscicidal and cercaricidal activities of curcumin on Biomphalaria glabrata and Schistosoma mansoni cercariae

Matos

Silva

Paula

et al. 2019

Pest Management Science

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“…The MIC value of 100-200 μg/mL is generally acceptable for plant materials [200]. Although the extracts of the parts of the genus Senna could not reach such MIC values, when the bioactive compounds are isolated from the extracts, MIC values decrease, and the antimicrobial properties increase [201]. Some of these bioactive components include stigmasterol, beta-sitosterol, kaempferol, luteolin, santal, alatonal, aloe-emodin, alquinone, chrysophanol, emodin, physcion, rhein, alarone, benzoquinone, coumarin, ellagitannin, naphthalene, phenolic acid, purine, xanthone, and cassine [202].…”

Section: Anti-infectious Activity Of Senna Plantsmentioning

confidence: 99%

“…Numerous studies reported antiprotozoal activities of genus Senna. de Castro et al [201] conducted a study about the schistosomicidal activity of S. spectabilis flower extracts. Schistosoma is an intestinal parasite that causes a chronic disease called Schistosomiasis.…”

Section: Stem-dichloromethanementioning

confidence: 99%

A Review of Recent Studies on the Antioxidant and Anti-Infectious Properties of Senna Plants

Alshehri

Quispe

Herrera‐Bravo

et al. 2022

Oxidative Medicine and Cellular Longevity

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The use of phytochemicals is gaining interest for the treatment of metabolic syndromes over the synthetic formulation of drugs. Senna is evolving as one of the important plants which have been vastly studied for its beneficial effects. Various parts of Senna species including the root, stem, leaves, and flower are found rich in numerous phytochemicals. In vitro, in vivo, and clinical experiments established that extracts from Senna plants have diverse beneficial effects by acting as a strong antioxidant and antimicrobial agent. In this review, Senna genus is comprehensively discussed in terms of its botanical characteristics, traditional use, geographic presence, and phytochemical profile. The bioactive compound richness contributes to the biological activity of Senna plant extracts. The review emphasizes on the in vivo and in vitro antioxidant and anti-infectious properties of the Senna plant. Preclinical studies confirmed the beneficial effects of the Senna plant extracts and its bioactive components in regard to the health-promoting activities. The safety, side effects, and therapeutic limitations of the Senna plant are also discussed in this review. Additional research is necessary to utilize the phenolic compounds towards its use as an alternative to pharmacological treatments and even as an ingredient in functional foods.

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“…Senna spectabilis, commonly known in Colombia as vainillo, is an ornamental fabaceae that derives its name from the Latin spectabilis, which means spectacular (4) . Currently, the vainillo has been studied especially for its leaves and flowers alkaloid content (5)(6)(7) . Alvear et al (8) determined the bromatological composition of the fruit, observing dry matter, crude protein, and crude energy values of 74.9%, 11.3%, and 3.82 Mcal/kg DM, respectively.…”

Section: Introductionmentioning

confidence: 99%

Senna spectabilis FRUIT ON HAIR LAMBS FEEDING: DIGESTIBILITY, BLOOD METABOLITES, AND RUMINAL KINETIC

2018

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In recent years sheep, farming has emerged as an alternative production system especially in dry areas. The use of leaves and fruit from some trees has become an alternative for feeding for ruminants; however, studies on these species are scarce. The objective of this study was to evaluate the effect of S. spectabilis fruit meal on in vivo and in vitro digestibility, blood metabolites, and ruminal kinetics in hair lambs. This study was carried out at Las Brisas farm, University of Tolima - Colombia. Twelve male hair lambs with body weight of 20.3 ± 2.5 kg were used. Animals were distributed in an experimental 4x4 Latin square design. The treatments consisted of diets based on Dichanthium spp hay with different inclusion levels of S. spectabilis fruit meal (15, 30, and 45%). A linear increasing effect (P <0.05) was observed for in vivo and in vitro digestibility of dry matter, organic matter, and crude protein; likewise, plasma urea and ruminal degradability increased as the level of supplementation of S. spectabilis increased. The meal of S. spectabilis improves digestibility, protein intake, and ruminal kinetics in hair lambs; therefore, it is suggested as a promising alternative for ruminants feeding in dry tropic regions.

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In vitro evaluation of the schistosomicidal effect of the extracts, fractions and major 3-hydroxy-2,6-dialkyl-substituted piperidine alkaloids from the flowers of Senna spectabilis (Fabaceae)

Cited by 12 publications

References 53 publications

Molluscicidal and cercaricidal activities of curcumin on Biomphalaria glabrata and Schistosoma mansoni cercariae

Molluscicidal and cercaricidal activities of curcumin on Biomphalaria glabrata and Schistosoma mansoni cercariae

A Review of Recent Studies on the Antioxidant and Anti-Infectious Properties of Senna Plants

Senna spectabilis FRUIT ON HAIR LAMBS FEEDING: DIGESTIBILITY, BLOOD METABOLITES, AND RUMINAL KINETIC

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