In vitro evaluation of the antimicrobial activity of nanosilver-mineral trioxide aggregate against frequent anaerobic oral pathogens by a membrane-enclosed immersion test

Bahador, Abbas; Pourakbari, Babak; Bolhari, Behnam; Hashemi, Farhad B.

doi:10.4103/2319-4170.132901

Cited by 31 publications

(11 citation statements)

References 30 publications

(32 reference statements)

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“…SNPC of 5.0 wt% exhibited significant inhibitory effects to both tested bacteria, which could be attributed to the elution of Ag + out of SPNC into the media, as shown by other studies of nanosilver-MTA composites. 2340 Furthermore, prolonged and persistent antimicrobial effect would be expected because silver-oxygen-silicate clusters detected by XRD might play a role in a reservoir of Ag + to elute. S. mutans and S. sobrinus were selected as the representative oral bacteria that primarily cause dental caries.…”

Section: Discussionmentioning

confidence: 99%

“…S. mutans and S. sobrinus were selected as the representative oral bacteria that primarily cause dental caries. S. sorbinus was more sensitive to lower Ag + concentration from SPNC, which can be explained by the different thickness and complexity of bacterial cell walls 40. Nevertheless, regarding the limitations of ADT, further studies are required to clarify the antimicrobial mechanism of SPNC including physicochemical factors such as electrostatic charge, hydrophobicity, or surface free energy.…”

Section: Discussionmentioning

confidence: 99%

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Characterization and antimicrobial efficacy of Portland cement impregnated with silver nanoparticles

Nam

2017

J Adv Prosthodont

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PURPOSEThis study investigated the effects of silver nanoparticle (SN) loading into hydraulic calcium silicate-based Portland cement on its mechanical, antibacterial behavior and biocompatibility as a novel dental bone substitute.MATERIALS AND METHODSChemically reduced colloidal SN were combined with Portland cement (PC) by the concentrations of 0 (control), 1.0, 3.0, and 5.0 wt%. The physico-mechanical properties of silver-Portland cement nanocomposites (SPNC) were investigated through X-ray diffraction (XRD), setting time, compressive strength, solubility, and silver ion elution. Antimicrobial properties of SPNC were tested by agar diffusion against Streptococcus mutans and Streptococcus sobrinus. Cytotoxic evaluation for human gingival fibroblast (HGF) was performed by MTS assay.RESULTSXRD certified that SN was successfully impregnated in PC. SPNC at above 3.0 wt% significantly reduced both initial and final setting times compared to control PC. No statistical differences of the compressive strength values were detected after SN loadings, and solubility rates of SPNC were below 3.0%, which are acceptable by ADA guidelines. Ag ion elutions from SPNC were confirmed with dose-dependence on the concentrations of SN added. SPNC of 5.0 wt% inhibited the growth of Streptococci, whereas no antimicrobial activity was shown in control PC. SPNC revealed no cytotoxic effects to HGF following ISO 10993 (cell viability > 70%).CONCLUSIONAddition of SN promoted the antibacterial activity and favored the bio-mechanical properties of PC; thus, SPNC could be a candidate for the futuristic dental biomaterial. For clinical warrant, further studies including the inhibitory mechanism, in vivo and long-term researches are still required.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Characterization and antimicrobial efficacy of Portland cement impregnated with silver nanoparticles

Nam

2017

J Adv Prosthodont

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“…The addition of NPs promoted antibacterial activity in Ca(OH) 2 [72,73] and other filling materials [74,75,76,77]. Calcium silicate cement such as mineral trioxide aggregate (MTA) and Portland cement (PC) showed antimicrobial effects, and their antimicrobial activity was significantly enhanced by mixing them with different concentrations of AgNPs [75,78].…”

Section: Antimicrobial Applications In Dentistrymentioning

confidence: 99%

Application of Antimicrobial Nanoparticles in Dentistry

2019

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Oral cavity incessantly encounters a plethora of microorganisms. Plaque biofilm—a major cause of caries, periodontitis and other dental diseases—is a complex community of bacteria or fungi that causes infection by protecting pathogenic microorganisms from external drug agents and escaping the host defense mechanisms. Antimicrobial nanoparticles are promising because of several advantages such as ultra-small sizes, large surface-area-to-mass ratio and special physical and chemical properties. To better summarize explorations of antimicrobial nanoparticles and provide directions for future studies, we present the following critical review. The keywords “nanoparticle,” “anti-infective or antibacterial or antimicrobial” and “dentistry” were retrieved from Pubmed, Scopus, Embase and Web of Science databases in the last five years. A total of 172 articles met the requirements were included and discussed in this review. The results show that superior antibacterial properties of nanoparticle biomaterials bring broad prospects in the oral field. This review presents the development, applications and underneath mechanisms of antibacterial nanoparticles in dentistry including restorative dentistry, endodontics, implantology, orthodontics, dental prostheses and periodontal field.

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“…It also has no reactive properties with any restorative material [24]. There are numerous MTA studies that evaluate antibacterial [25]; antimicrobial [26]; and antifungal [27] properties. Considering all those useful properties mentioned above; this study was carried out to evaluate the antimutagenic and antioxidant properties of MTA.…”

Section: Introductionmentioning

confidence: 99%

Determination of the Free Radical Scavenging and Antimutagenic Activity of Mineral Trioxide Aggregate, Root Canal Treatment Material Used In Dentistry

Uğur

Saraç

Karaca

et al. 2018

ijmsci

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Objectives: The purpose of this study is to evaluate the mutagenicity, antimutagenic and radical scavenging activities of Mineral Trioxide Aggregate (MTA), a material widely used in various dental procedures. Although there have been several studies that discuss MTA's antifungal and antibacterial properties, we believe this will be the first report to evaluate the antimutagenic and radical scavenging properties. Methods: Free radical scavenging activity was determined according to the elimination of 1,1-diphenyl-2-picryl hydrazyl (DPPH) radicals. Antimutagenesis studies were performed with the Salmonella/microsome mutagenesis test. These assays were done on Salmonella typhimurium TA98 and TA100. Results: MTA has low radical scavenging activity with a total of 8.95% and revealed strong antimutagenic effects at all of the tested concentrations. Significance: Considering the results obtained in this study, MTA showed great antimutagenic attributes which may be considered a positive feature for a material widely used in dentistry.

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In vitro evaluation of the antimicrobial activity of nanosilver-mineral trioxide aggregate against frequent anaerobic oral pathogens by a membrane-enclosed immersion test

Cited by 31 publications

References 30 publications

Characterization and antimicrobial efficacy of Portland cement impregnated with silver nanoparticles

Characterization and antimicrobial efficacy of Portland cement impregnated with silver nanoparticles

Application of Antimicrobial Nanoparticles in Dentistry

Determination of the Free Radical Scavenging and Antimutagenic Activity of Mineral Trioxide Aggregate, Root Canal Treatment Material Used In Dentistry

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