In vitro evaluation of MgSr and MgCaSr alloys via direct culture with bone marrow derived mesenchymal stem cells

Jiang, Wensen; Cipriano, Aaron F.; Tian, Qiang; Zhang, Chaoxing; Marisa, Lopez; Sallee, Amy; Lin, Alan; Alcaraz, Mayra Celene Cortez; Wu, Yuanhao; Zheng, Yufeng; Liu, Huinan

doi:10.1016/j.actbio.2018.03.049

Cited by 52 publications

(34 citation statements)

References 61 publications

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“…Strontium (Sr) presents in group 2 of periodic table along with Mg and Ca, possesses the bone formation property similar to Mg and Ca . Sr is a vital trace element of the human body and 99 wt % of its body content is in bones . Sr enhances the bone formation by accelerating the bone tissue growth and also slows down bone resorption .…”

Section: Mg and Its Alloysmentioning

confidence: 99%

“…Sr is a vital trace element of the human body and 99 wt % of its body content is in bones . Sr enhances the bone formation by accelerating the bone tissue growth and also slows down bone resorption . The alloying of Mg with Sr leads to the refinement of grain sizes of Mg .…”

Section: Mg and Its Alloysmentioning

confidence: 99%

“…Sr is not only biocompatible in nature but it is also bioactive with great potential for bone formation . These properties make Sr a suitable material to alloy with Mg for implant applications.…”

Section: Mg and Its Alloysmentioning

confidence: 99%

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The current trends of Mg alloys in biomedical applications—A review

2018

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Magnesium (Mg) has emerged as an ideal alternative to the permanent implant materials owing to its enhanced properties such as biodegradation, better mechanical strengths than polymeric biodegradable materials and biocompatibility. It has been under investigation as an implant material both in cardiovascular and orthopedic applications. The use of Mg as an implant material reduces the risk of long-term incompatible interaction of implant with tissues and eliminates the second surgical procedure to remove the implant, thus minimizes the complications. The hurdle in the extensive use of Mg implants is its fast degradation rate, which consequently reduces the mechanical strength to support the implant site. Alloy development, surface treatment, and design modification of implants are the routes that can lead to the improved corrosion resistance of Mg implants and extensive research is going on in all three directions. In this review, the recent trends in the alloying and surface treatment of Mg have been discussed in detail. Additionally, the recent progress in the use of computational models to analyze Mg bioimplants has been given special consideration.

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Section: Mg and Its Alloysmentioning

confidence: 99%

Section: Mg and Its Alloysmentioning

confidence: 99%

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The current trends of Mg alloys in biomedical applications—A review

2018

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“…2,3 In the past few decades, biomedical implants based on metals, polymers, ceramics and their composites or hybrids have been extensively studied and reported. [4][5][6][7][8][9][10][11][12][13][14] Based on the diverse physicochemical properties of different materials, various fabrication strategies have been developed involving 3D printing, eco-friendly supercritical uid technology, electrospinning, etc. [15][16][17][18] For instance, 3D printing has been widely utilized to fabricate polymer-based scaffolds with desired porous architectures in a precise way.…”

Section: Introductionmentioning

confidence: 99%

Polydopamine-modified poly(l-lactic acid) nanofiber scaffolds immobilized with an osteogenic growth peptide for bone tissue regeneration

Liu

et al. 2019

RSC Adv.

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“…Magnesium alloys have attracted extensive attention for medical applications because of their good biocompatibility, biodegradability and elastic modulus similar to natural bone as orthopaedic and cardiovascular implant [1][2][3] . Nevertheless, traditional Mg alloys are degraded before the tissue is healed after implantation, leading to failure of the surgery, which limits the applications of the magnesium alloys to a great extent 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Effect of Ca Content on Properties of Extruded Mg-3Zn-0.5Sr-xCa Alloys for Medical Applications

et al. 2019

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Mg-3Zn-0.5Sr-xCa(wt.%) (x=0, 0.2, 0.5) alloys were fabricated by casting and hot extrusion. X-ray diffraction (XRD) and optical microscopy observation showed that the microstructure of Mg-3Zn-0.5Sr-xCa alloys was composed of α-Mg matrix and Mg 17 Sr 2 phase precipitated along grain boundaries. The tensile strength of the alloy increased from 255MPa to 305MPa with increasing Ca content from 0 to 0.5wt%, but the elongation to fracture of the alloys was 19.45%, 28.7% and 15.2% respectively, indicating that coarse precipitation increased the risk of crack initiation and propagation along the grain boundaries leading to reduced ductility of Mg alloys. The polarization curves revealed that Mg-3Zn-0.5Sr-0.2Ca has the highest corrosion potential and the lowest corrosion current density indicating the optimum corrosion resistance. In cytotoxicity test, Mg-3Zn-0.5Sr-xCa alloys were harmless to mouse osteoblastic and Mg-3Zn-0.5Sr-0.2Ca alloy exhibited optimal biocompatibility.

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In vitro evaluation of MgSr and MgCaSr alloys via direct culture with bone marrow derived mesenchymal stem cells

Cited by 52 publications

References 61 publications

The current trends of Mg alloys in biomedical applications—A review

The current trends of Mg alloys in biomedical applications—A review

Polydopamine-modified poly(l-lactic acid) nanofiber scaffolds immobilized with an osteogenic growth peptide for bone tissue regeneration

Effect of Ca Content on Properties of Extruded Mg-3Zn-0.5Sr-xCa Alloys for Medical Applications

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