In vitro evaluation of injectable Tideglusib-loaded hyaluronic acid hydrogels incorporated with Rg1-loaded chitosan microspheres for vital pulp regeneration

Atila, Deniz; Chen, Ching Yun; Lin, Chun-Pin; Lee, Yuan-Ling; Hasırcı, Vasıf; Tezcaner, Ayşen; Lin, Feng-Huei

doi:10.1016/j.carbpol.2021.118976

Cited by 14 publications

(14 citation statements)

References 58 publications

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“…Previous studies have reported the beneficial effects of Tideglusib (Td) and melatonin (Mel) on pulp regeneration. Td promotes the healing process of hard tissues, such as bone or teeth [269][270][271], and Mel promotes odontogenic differentiation [272,273]. Based on this, Atila et al combined an injectable GelMA/PecTH hydrogel with core/shell PMMA/SF fibers loaded with Mel in the core and Td in the shell, which were successively released to promote hDPSCs proliferation and odontogenic differentiation [274].…”

Section: Application Of Sf Hydrogels In Teethmentioning

confidence: 99%

Application of Silk-Fibroin-Based Hydrogels in Tissue Engineering

Lyu

Liu

et al. 2023

Gels

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Silk fibroin (SF) is an excellent protein-based biomaterial produced by the degumming and purification of silk from cocoons of the Bombyx mori through alkali or enzymatic treatments. SF exhibits excellent biological properties, such as mechanical properties, biocompatibility, biodegradability, bioabsorbability, low immunogenicity, and tunability, making it a versatile material widely applied in biological fields, particularly in tissue engineering. In tissue engineering, SF is often fabricated into hydrogel form, with the advantages of added materials. SF hydrogels have mostly been studied for their use in tissue regeneration by enhancing cell activity at the tissue defect site or counteracting tissue-damage-related factors. This review focuses on SF hydrogels, firstly summarizing the fabrication and properties of SF and SF hydrogels and then detailing the regenerative effects of SF hydrogels as scaffolds in cartilage, bone, skin, cornea, teeth, and eardrum in recent years.

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Section: Application Of Sf Hydrogels In Teethmentioning

confidence: 99%

Application of Silk-Fibroin-Based Hydrogels in Tissue Engineering

Lyu

Liu

et al. 2023

Gels

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“…Atila et al combined injectable hyaluronic acid hydrogel (HAH) with RG1-loaded chitosan microspheres (CSM) to trigger odontoblast differentiation of hDPSC and vascularization of dental pulp. At the gene expression level, hydrogel-cultured DPSCs showed odontogenic differentiation (COL1A1, ALP, OCN, Axin-2, DSPP and DMP1) and angiogenic differentiation (VEGFA, VEGFR2 and eNOS) [ 33 ]. Zhang et al prepared Gd-alginate/laponite (RGD-Alg/Lap) hydrogel microspheres with an average size of 350~450 μm by the electrostatic microdroplet method.…”

Section: Application Of Hydrogel In Pulp Tissue Regenerationmentioning

confidence: 99%

Research Advances on Hydrogel-Based Materials for Tissue Regeneration and Remineralization in Tooth

Zhang

Guo

2023

Gels

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Tissue regeneration and remineralization in teeth is a long-term and complex biological process, including the regeneration of pulp and periodontal tissue, and re-mineralization of dentin, cementum and enamel. Suitable materials are needed to provide cell scaffolds, drug carriers or mineralization in this environment. These materials need to regulate the unique odontogenesis process. Hydrogel-based materials are considered good scaffolds for pulp and periodontal tissue repair in the field of tissue engineering due to their inherent biocompatibility and biodegradability, slow release of drugs, simulation of extracellular matrix, and the ability to provide a mineralized template. The excellent properties of hydrogels make them particularly attractive in the research of tissue regeneration and remineralization in teeth. This paper introduces the latest progress of hydrogel-based materials in pulp and periodontal tissue regeneration and hard tissue mineralization and puts forward prospects for their future application. Overall, this review reveals the application of hydrogel-based materials in tissue regeneration and remineralization in teeth.

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“…61 Furthermore, utilizing cells, biologically active molecules, and morphologically suitable scaffolds can be an option to promote pulp tissue regeneration more and to restore the functions of the pulp. 56,[62][63][64] Antimicrobial hydrogels recently developed for endodontics and their multifunctional properties (if there are any) were listed in Table 1.…”

Section: Antimicrobial Hydrogels Developed For Endodonticsmentioning

confidence: 99%