In Vitro Evaluation of Essential Mechanical Properties and Cell Behaviors of a Novel Polylactic-co-Glycolic Acid (PLGA)-Based Tubular Scaffold for Small-Diameter Vascular Tissue Engineering

Wang, Nuoxin; Zheng, Wenfu; Cheng, Shiyu; Zhang, Wei; Liu, Shaoqin; Jiang, Xingyu

doi:10.3390/polym9080318

Cited by 33 publications

(24 citation statements)

References 60 publications

(79 reference statements)

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“…Based on the intrinsic advantage of precise control of fluid routing, microfluidics technology provides an ideal platform for recapitulating blood vessel‐on‐a‐chip model. A series of cell‐laden tubular structures can mimic native blood vessels based on microfluidic channels and stress‐induced rolling membrane technique . Researchers introduce a unique strategy that can generate mimic tubular structures with different types of cells deposited at different layers ( Figure A) .…”

Section: Cells‐on‐chipsmentioning

confidence: 99%

Microfluidics‐Based Biomaterials and Biodevices

et al. 2018

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.201805033.The rapid development of microfluidics technology has promoted new innovations in materials science, particularly by interacting with biological systems, based on precise manipulation of fluids and cells within microscale confinements. This article reviews the latest advances in microfluidics-based biomaterials and biodevices, highlighting some burgeoning areas such as functional biomaterials, cell manipulations, and flexible biodevices. These areas are interconnected not only in their basic principles, in that they all employ microfluidics to control the makeup and morphology of materials, but also unify at the ultimate goals in human healthcare. The challenges and future development trends in biological application are also presented. Microfluidics

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Section: Cells‐on‐chipsmentioning

confidence: 99%

Microfluidics‐Based Biomaterials and Biodevices

et al. 2018

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“…The (self‐)assembled 3D structures may also be used for biological applications. As typical self‐assembled structure, the microtubes made from rolled‐up nanomembranes, has been used for cell culture experiments . The mechanical interactions between the cells and the rolled‐up nanomembranes were found to influence the arrangement of the inside cells (panel (i) of Figure c).…”

Section: Biomimetic Nanomembranesmentioning

confidence: 99%

Assembly and Self‐Assembly of Nanomembrane Materials—From 2D to 3D

Huang

Mei

2018

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Nanoscience and nanotechnology offer great opportunities and challenges in both fundamental research and practical applications, which require precise control of building blocks with micro/nanoscale resolution in both individual and mass-production ways. The recent and intensive nanotechnology development gives birth to a new focus on nanomembrane materials, which are defined as structures with thickness limited to about one to several hundred nanometers and with much larger (typically at least two orders of magnitude larger, or even macroscopic scale) lateral dimensions. Nanomembranes can be readily processed in an accurate manner and integrated into functional devices and systems. In this Review, a nanotechnology perspective of nanomembranes is provided, with examples of science and applications in semiconductor, metal, insulator, polymer, and composite materials. Assisted assembly of nanomembranes leads to wrinkled/buckled geometries for flexible electronics and stacked structures for applications in photonics and thermoelectrics. Inspired by kirigami/origami, self-assembled 3D structures are constructed via strain engineering. Many advanced materials have begun to be explored in the format of nanomembranes and extend to biomimetic and 2D materials for various applications. Nanomembranes, as a new type of nanomaterials, allow nanotechnology in a controllable and precise way for practical applications and promise great potential for future nanorelated products.

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“…PLGA is often used as substrates for bone tissue engineering, which has demonstrated to be non-inflammatory and biocompatible [7]. However, due to its poor osteogenic bioactivity and low mechanical strength, their biological applications have been limited to some extent [8]. Therefore, to achieve some of the desired properties, researchers often combine the advantages of two biomaterials.…”

Section: Introductionmentioning

confidence: 99%