In vitro evaluation of anthraquinones from Aloe vera (Aloe barbadensis Miller) roots and several derivatives against strains of influenza virus

Borges-Argáez, Rocı́o; Chan-Balan, Reyna; Cetina-Montejo, Lisseth; Ayora-Talavera, Guadalupe; Sansores-Peraza, Pablo; Gómez-Carballo, Jesús; Cáceres-Farfan, Mirbella

doi:10.1016/j.indcrop.2019.02.056

Cited by 50 publications

(27 citation statements)

References 33 publications

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“…According to a review in 2019, acemannan is the major bioactive polysaccharide derived from AV gel [ 49 ]. Acemannan, AV polysaccharides and anthraquinones revealed antiviral activity against the human influenza A virus (H1N1) [ 54 , 55 ]. Hence, acemannan content depends on species and cultivation conditions, irrigation with seawater, harvest season, growth age and solar irradiation intensities [ 49 ].…”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis of Antimicrobial Aloe Vera-“Smart” Triiodide-PVP Biomaterials

2020

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Antibiotic resistance is an eminent threat for the survival of mankind. Nosocomial infections caused by multidrug resistant microorganisms are a reason for morbidity and mortality worldwide. Plant-based antimicrobial agents are based on synergistic mechanisms which prevent resistance and have been used for centuries against ailments. We suggest the use of cost-effective, eco-friendly Aloe Vera Barbadensis Miller (AV)-iodine biomaterials as a new generation of antimicrobial agents. In a facile, one-pot synthesis, we encapsulated fresh AV gel with polyvinylpyrrolidone (PVP) as a stabilizing agent and incorporated iodine moieties in the form of iodine (I2) and sodium iodide (NaI) into the polymer matrix. Ultraviolet-visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR), x-ray diffraction (XRD), microstructural analysis by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) verified the composition of AV-PVP-I2, AV-PVP-I2-NaI. AV, AV-PVP, AV-PVP-I2, AV-PVP-I2-NaI, and AV-PVP-NaI were tested in-vitro by disc diffusion assay and dip-coated on polyglycolic acid (PGA) sutures against ten microbial reference strains. All the tested pathogens were more susceptible towards AV-PVP-I2 due to the inclusion of “smart” triiodides with halogen bonding in vitro and on dip-coated sutures. The biocomplexes AV-PVP-I2, AV-PVP-I2-NaI showed remarkable antimicrobial properties. “Smart” biohybrids with triiodide inclusions have excellent antifungal and promising antimicrobial activities, with potential use against surgical site infections (SSI) and as disinfecting agents.

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Section: Introductionmentioning

confidence: 99%

Facile Synthesis of Antimicrobial Aloe Vera-“Smart” Triiodide-PVP Biomaterials

2020

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“…The acetylated glucose by itself was unable to cause a CPE reduction against influenza viruses. 91 94 Further investigations showed that 108 had broad-spectrum inhibitory activity against the wild types of influenza A and B viruses with EC 50 values between 16.45 ± 0.10 and 69.67 ± 3.23 μM, which were similar to that of ribavirin (72.95 ± 3.27 μM). In addition, it is probable that 108 selectively suppressed viral mRNA synthesis in infected cells without cytotoxicity.…”

Section: F I G U R Ementioning

confidence: 94%

“…The SAR analysis suggested that acetylation, methylation and O ‐glycosyl addition did not improve the antiviral activities; however, if an acetyl sugar was added, a moderate antiviral effect was observed. The acetylated glucose by itself was unable to cause a CPE reduction against influenza viruses 91 …”

Section: Anti‐influenza Natural Products and Derivativesmentioning

confidence: 98%

Development of anti‐influenza agents from natural products

Zhang

Morris‐Natschke

Cheng

et al. 2020

Medicinal Research Reviews

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“…Induce cellular and humoral response iii. Stimulate cytokines and chemokines Avian influenza Recombinant fowl pox virus vector–based avian influenza vaccine (rFPV) [ 68 ] 2 Aloe vera Asphodelaceae Roots Anthraquinones:3-(2´,3´,4´,6´-Tetra-O-acetyl-β- d -glucopyranosyl-aloesaponarin-I (5) and 3-(2´,3´,4´,6´-Tetra-O-acetyl-β- d -glucopyranosyl- aloesaponarin-II (7) Inhibit virus replication Influenza A H1N1 A/Yucatán/2370/09, A/Mexico/InDRE797/10 (H1N1) [ 69 ] 3 Alpinia officinarum Zingiberaceae Rhizomes Diarylheptanoids: 7-4″-hydroxy-3″-methoxyphenyl)-1-phenyl-4E-hepen-3-one (3) and (5S)-5-hydroxy-7-(4″-hydroxyphenyl)-1-phenyl-3-heptanone (8) Potent anti-influenza activity Influenza A H1N1 A/PR/8/34( H1N1) [ 70 ] Diarylheptanoids: 7-4″-hydroxy-3″-methoxyphenyl)-1-phenyl-4E-hepen-3-one (AO-0002) and (5S)-5-hydroxy-7-(4″-hydroxyphenyl)-1-phenyl-3-heptanone (AO-0011) AO-0002: i. Suppress the expression of viral antigen and mRNA synthesis ii.Reduce the bodyweight loss and iii.…”

Section: Alternate Therapiesmentioning

confidence: 99%

Substantial effect of phytochemical constituents against the pandemic disease influenza—a review

Devi

Sarala

2021

Futur J Pharm Sci

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Background Influenza is an acute respiratory tract infection caused by the influenza virus. Vaccination and antiviral drugs are the two methods opted to control the disease. Besides their efficiency, they also cause adverse side effects. Hence, scientists turned their attention to powerful herbal medicines. This review put focus on various proven, scientifically validated anti-influenza compounds produced by the plants suggested for the production of newer drugs for the better treatment of influenza and its related antiviral diseases too. Main body In this review, fifty medicinal herb phytochemical constituents and their anti-influenza activities have been documented. Specifically, this review brings out the accurate and substantiates mechanisms of action of these constituents. This study categorizes the phytochemical constituents into primary and secondary metabolites which provide a source for synthesizing and developing new drugs. Conclusion This article provides a summary of the actions of the herbal constituents. Since the mechanisms of action of the components are elucidated, the pandemic situation arising due to influenza and similar antiviral diseases can be handled promisingly with greater efficiency. However, clinical trials are in great demand. The formulation of usage may be a single drug compound or multi-herbal combination. These, in turn, open up a new arena for the pharmaceutical industries to develop innovative drugs.

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In vitro evaluation of anthraquinones from Aloe vera (Aloe barbadensis Miller) roots and several derivatives against strains of influenza virus

Cited by 50 publications

References 33 publications

Facile Synthesis of Antimicrobial Aloe Vera-“Smart” Triiodide-PVP Biomaterials

Facile Synthesis of Antimicrobial Aloe Vera-“Smart” Triiodide-PVP Biomaterials

Development of anti‐influenza agents from natural products

Substantial effect of phytochemical constituents against the pandemic disease influenza—a review

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