Development of anti‐influenza agents from natural products

Zhang, Zhi‐Jun; Morris‐Natschke, Susan L.; Cheng, Yung Yi; Lee, Kuo‐Hsiung; Li, Rong‐Tao

doi:10.1002/med.21707

Cited by 60 publications

(36 citation statements)

References 203 publications

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“…An alternative approach is the search of novel antiviral compounds extracted from natural sources. As noted by Zhang et al, 37% of the 98 antiviral drugs registered from January 1981 to September 2019 pertain to natural product botanical medicines, synthetic but natural product mimics, or a combination of these two options [126] (see also [127]). A representative example is oseltamivir, which can be synthesized using quinic and shikimic acids, i.e., two natural products, as starting materials.…”

Section: Expert Opinionmentioning

confidence: 99%

“…A representative example is oseltamivir, which can be synthesized using quinic and shikimic acids, i.e., two natural products, as starting materials. Pharmacological studies have also disclosed other anti-influenza agents that include a variety of chemical scaffolds, such as terpenoids, quinones, diarylheptanoids, phenylpropanoids, polyphenols, flavonoids, and alkaloids, isolated from traditional herbs [126,128]. Therefore, they can be an inspiration source for accelerating the development of effective anti-influenza drugs.…”

Section: Expert Opinionmentioning

confidence: 99%

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Searching for effective antiviral small molecules against influenza A virus: A patent review

Ginex

Luque

2020

Expert Opinion on Therapeutic Patents

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Introduction: Despite the current interest caused by SARS-Cov-2, influenza continues to be one of the most serious health concerns, with an estimated 1 billion cases across the globe, including 3-5 million severe cases and 290,000-650,000 deaths worldwide.Areas covered: This manuscript reviews the efforts made in the development of small molecules for the treatment of influenza virus, primarily focused on patent applications in the last 5 years. Attention is paid to compounds targeting key functional viral proteins, such as the M2 channel, neuraminidase, and hemagglutinin, highlighting the evolution toward new ligands and scaffolds motivated by the emergence of resistant strains. Finally, the discovery of compounds against novel viral targets, such as the RNA-dependent RNA polymerase, is discussed. Expert opinion: The therapeutic potential of antiviral agents is limited by the increasing presence of resistant strains. This should encourage research on novel strategies for therapeutic intervention. In this context, the discovery of arbidol and JNJ7918 against hemagglutinin, and current efforts on RNA-dependent RNA polymerase have disclosed novel opportunities for therapeutic treatment. Studies should attempt to expand the therapeutic arsenal of anti-flu agents, often in combined therapies, to prevent future health challenges caused by influenza virus.

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Section: Expert Opinionmentioning

confidence: 99%

Section: Expert Opinionmentioning

confidence: 99%

Searching for effective antiviral small molecules against influenza A virus: A patent review

Ginex

Luque

2020

Expert Opinion on Therapeutic Patents

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“…Traditional Chinese medicine (TCM) and its prescriptions, especially the classical prescriptions, have long been used in clinics in China, and are revitalized recently due to people's increasing health needs [1,2]. Multiple approaches have been attempted to dig into the chemical components of TCM prescriptions [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Systematic characterization of chemical constituents in Mahuang decoction by UHPLC tandem linear ion trap‐Orbitrap mass spectrometry coupled with feature‐based molecular networking

Ling

Yao

et al. 2021

J of Separation Science

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Comprehensive characterization of traditional Chinese medicine prescriptions has long been a hurdle due to the chemical complexity and the lack of analytical tools. Mahuang decoction is a well-known traditional Chinese medicine prescription widely used for sweating and relieving the exterior, relieving cough and asthma, but it was insufficiently chemically scrutinized. In this study, the chemical component information of Mahuang decoction was investigated by ultrahigh-performance liquid chromatography tandem linear ion trap-Orbitrap mass spectrometry. A new data processing tool, feature-based molecular networking, was introduced for grouping and elucidating the compounds. In this way, 156 chemical components were identified or tentatively characterized, including alkaloids, triterpenoid saponins, flavanone-O-glycosides, flavone-Cglycosides, and procyanidins. Thus, this research provides a solid foundation for further development of Mahuang decoction, and the adopted method is expected to be applied to other traditional Chinese medicine prescriptions.

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“…LH capsule, one of natural product, was a manufactured product of the TCM prescription marketed in China that could signi cantly inhibit SARS-CoV-2 replication [6] . LH capsule exerts its antiin uenza activity by regulating the immune response to interfere with both viral and host reactions [7] . The LH capsule has been endorsed by the National Health Commission for treatment of Covid-19, the prospective randomized study including 284 patients conducted in multicenter settings suggest that the treatment with LH capsules for 14 days markedly improved the rate of symptom recovery [8] .…”

Section: Introductionmentioning

confidence: 99%

Rapid Resolution of severe feline infectious peritonitis using natural products

Zhang¹,

Zhang²,

Zhu³

et al. 2021

Preprint

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This is the first report of a successful treatment of a severe feline infectious peritonitis (FIP) case using Lianhuaqingwen (LH) capsule, a Chinese patent medicine （natural products）and it has been used for the treatment of coronavirus disease 2019. A 1-year-old cat was diagnosed FIP and presented with severe ascites, aphagia, inflammation, breathing difficulties and weight loss. Within 22 days of LH capsule treatment, all indicators of the cat eventually returned to normal, and the ascites gradually disappeared. This case report is the first description of the clinical recovery features of a cat with a systemic FCoV infection using LH capsules.

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Development of anti‐influenza agents from natural products

Cited by 60 publications

References 203 publications

Searching for effective antiviral small molecules against influenza A virus: A patent review

Searching for effective antiviral small molecules against influenza A virus: A patent review

Systematic characterization of chemical constituents in Mahuang decoction by UHPLC tandem linear ion trap‐Orbitrap mass spectrometry coupled with feature‐based molecular networking

Rapid Resolution of severe feline infectious peritonitis using natural products

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