In vitro erythrocytic membrane effects of dibenzyl trisulfide, a secondary metabolite of Petiveria alliacea

Pepple, D.J.; Richards, A.A.; Lowe, Dorrit; Reid, Walton; Younger, Novie; Williams, Lawrence A. D.

doi:10.1016/j.fitote.2010.07.006

Cited by 6 publications

(4 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Williams et al discovered that DBTS and serum albumin interact to yield a complex that prevents protein denaturation and displays 2000-fold enhanced cytotoxicity (i.e., antiproliferative activity): Specifically, the IC 50 value found for SH-SY5Y neuroblastoma cells is about 3 ng/mL (209,270,271); DBTS also displays high affinity for erythrocytic membranes, dose dependently increasing their elasticity and relaxation time (194).…”

Section: Dibenzyl Disulfide and Dibenzyl Polysulfidesmentioning

confidence: 99%

SG1002 and Catenated Divalent Organic Sulfur Compounds as Promising Hydrogen Sulfide Prodrugs

Gojon¹,

Morales²

2020

Antioxidants & Redox Signaling

View full text Add to dashboard Cite

Significance: Sulfur has a critical role in protein structure/function and redox status/signaling in all living organisms. Although hydrogen sulfide (H 2 S) and sulfane sulfur (SS) are now recognized as central players in physiology and pathophysiology, the full scope and depth of sulfur metabolome's impact on human health and healthy longevity has been vastly underestimated and is only starting to be grasped. Since many pathological conditions have been related to abnormally low levels of H 2 S/SS in blood and/or tissues, and are amenable to treatment by H 2 S supplementation, development of safe and efficacious H 2 S donors deserves to be undertaken with a sense of urgency; these prodrugs also hold the promise of becoming widely used for disease prevention and as antiaging agents. Recent Advances: Supramolecular tuning of the properties of well-known molecules comprising chains of sulfur atoms (diallyl trisulfide [DATS], S 8) was shown to lead to improved donors such as DATS-loaded polymeric nanoparticles and SG1002. Encouraging results in animal models have been obtained with SG1002 in heart failure, atherosclerosis, ischemic damage, and Duchenne muscular dystrophy; with TC-2153 in Alzheimer's disease, schizophrenia, age-related memory decline, fragile X syndrome, and cocaine addiction; and with DATS in brain, colon, gastric, and breast cancer. Critical Issues: Mode-of-action studies on allyl polysulfides, benzyl polysulfides, ajoene, and 12 ringsubstituted organic disulfides and thiosulfonates led several groups of researchers to conclude that the anticancer effect of these compounds is not mediated by H 2 S and is only modulated by reactive oxygen species, and that their central model of action is selective protein S-thiolation. Future Directions: SG1002 is likely to emerge as the H 2 S donor of choice for acquiring knowledge on this gasotransmitter's effects in animal models, on account of its unique ability to efficiently generate H 2 S without byproducts and in a slow and sustained mode that is dose independent and enzyme independent. Efficient tuning of H 2 S donation characteristics of DATS, dibenzyl trisulfide, and other hydrophobic H 2 S prodrugs for both oral and parenteral administration will be achieved not only by conventional structural modification of a lead molecule but also through the new ''supramolecular tuning'' paradigm. Antioxid. Redox Signal. 33, 1010-1045.

show abstract

Section: Dibenzyl Disulfide and Dibenzyl Polysulfidesmentioning

confidence: 99%

SG1002 and Catenated Divalent Organic Sulfur Compounds as Promising Hydrogen Sulfide Prodrugs

Gojon¹,

Morales²

2020

Antioxidants & Redox Signaling

View full text Add to dashboard Cite

show abstract

“…Viscoelasticity is therefore an index of the deformability and functionality of red blood cells. Cells with less elastic storage energy will require less energy for deformation and are therefore more deformable, that is the higher the elasticity of the membrane, the more rigid it is and therefore the less deformable [8].…”

Section: Introductionmentioning

confidence: 99%

The in vitro effects of sulfadoxine/pyrimethamine and artemether/lumefantrine on the viscoelasticity of erythrocyte membrane of healthy females

Richards

McKoy

et al. 2014

Clinical Hemorheology and Microcirculation

Self Cite

View full text Add to dashboard Cite

Fansidar ® (sulfadoxine/pyrimethamine) and Coartem ® (artemether/lumefantrine) are drugs that destroy malarial parasites and also produce free radicals which cause hemolysis of malaria-parasitized erythrocytes. This study investigated the effect of these drugs on the viscoelasticity of erythrocytes of ten healthy female subjects using the BioProfiler. The concentration for each of the two drugs were determined based on the therapeutic dose as normal, half the therapeutic dose as low and double the therapeutic dose as high. For Fansidar ® , the concentrations were 0.15/0.01 mg/ml (low), 0.30/0.02 mg/ml (normal) and 0.60/0.04 mg/ml (high) based on the adult therapeutic dose of 1500/75 mg of sulfadoxine/pyrimethamine in the drug combination. For Coartem ® , the concentrations were 0.03/0.19 mg/ml (low), 0.06/0.38 mg/ml (normal) and 0.12/0.76 mg/ml (high) based on the adult therapeutic dose of 320/1920 mg of artermether/lumefantrine in the drug combination. There was a statistically significant (p < 0.05) decrease in viscosity, elasticity and relaxation time with Coartem ® at normal and high doses. Fansidar ® also showed significant (p < 0.05) reductions in these parameters only in the high dose. This suggests that Coartem ® generated significant free radicals at normal and high doses, with Fansidar ® only in the high dose, resulting in increased hemolysis and ultimately reduced viscoelasticity.

show abstract

“…A Vilastic bioprofiler (Vilastic Scientific Inc., Austin, TX) was used to determine PV and WBV. 25 The bioprofiler has the capacity to measure WBV in sample sizes between 0.5 and 1 mL. Its vessel-like geometry allowed for more precise simulation of in vivo conditions.…”

Section: Whole Blood and Plasma Viscositymentioning

confidence: 99%

Erythrocyte Aggregation and Blood Viscosity is Similar in Homozygous Sickle Cell Disease Patients with and without Leg Ulcers

2018

View full text Add to dashboard Cite

There is no consensus regarding the role of red blood cell (RBC) aggregation in the pathogenesis of leg ulcers (LUs) in sickle cell disease (SCD). We sought to evaluate whether the cross-sectional determination of RBC aggregation and hematological indices were associated with the presence of LU in homozygous SCD. Twenty-seven patients with LU and 23 with no history of ulceration were recruited into the study. A laser-assisted rotational red cell analyzer (LoRRca) was used in the determination of the aggregation index (AI), aggregation half-time ( ), and the RBC aggregate strength (AMP). Hematological indices were determined using a CELL-DYN Ruby analyzer. Whole blood viscosity (WBV) and plasma viscosity (PV) were measured using a Vilastic bioprofiler. The data were presented as means ± standard deviation or median, interquartile range. Two-sample -test was used to test for associations between the AIs, WBV, and PV in patients with and without LU. Statistical significance was taken as < 0.05. All analyses were conducted using Stata/SE . 12.1 (StataCorp, College Station, TX). The AI was comparable in the group with and without ulcers (68.6, 16.7 versus 67.7, 16.9; = 0.74); (1.7, 1.3 versus 1.8, 1.3; = 0.71); AMP (18.8, 14.5 versus 19.1, 13.3; = 0.84), WBV (3.8, 1.2 versus 3.8, 0.7; = 0.77); and the PV (1.3, 0.08 versus 1.4, 0.1; = 0.31) and were also not statistically different between the groups of participants. RBC aggregation and aggregate strength are not associated with leg ulceration in SCD.

show abstract

In vitro erythrocytic membrane effects of dibenzyl trisulfide, a secondary metabolite of Petiveria alliacea

Cited by 6 publications

References 3 publications

SG1002 and Catenated Divalent Organic Sulfur Compounds as Promising Hydrogen Sulfide Prodrugs

SG1002 and Catenated Divalent Organic Sulfur Compounds as Promising Hydrogen Sulfide Prodrugs

The in vitro effects of sulfadoxine/pyrimethamine and artemether/lumefantrine on the viscoelasticity of erythrocyte membrane of healthy females

Erythrocyte Aggregation and Blood Viscosity is Similar in Homozygous Sickle Cell Disease Patients with and without Leg Ulcers

Contact Info

Product

Resources

About