In Vitro Enzyme Inhibitory Properties, Secondary Metabolite Profiles and Multivariate Analysis of Five Seaweeds

Mahomoodally, Mohamad Fawzi; Sadeer, Nabeelah Bibi; Zengin, Gökhan; Cziáky, Zoltán; Jekő, József; Diuzheva, Alina; Sinan, Kouadio Ibrahime; Palaniveloo, Kishneth; Kim, Doo Hwan; Rengasamy, Kannan R.R.

doi:10.3390/md18040198

Cited by 11 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It appears too high to be credible (see also, e.g., Neeley et al, [72]). Mahomoodally et al [73] reported IC 50 values on the order of 3.5-4.5 mg/mL for methanolic extracts of Halimeda spp., Valoniopsis pachynema (Chlorophyta), Gracilaria debilis (formerly Gracilaria fergusonii) Spyridia hypnoides and Amphiroa anceps (Rhodophyta) while the ethanol extract of Turbinaria conoides (Ochrophyta, Phaeophyceae) exhibits IC 50 value of 188.85 µg/mL [74]. All these activities are much lower than the ones presented here.…”

Section: Tyrosinase Inhibitionmentioning

confidence: 99%

Pharmacological and Cosmeceutical Potential of Seaweed Beach-Casts of Macaronesia

et al. 2020

View full text Add to dashboard Cite

Seaweed beach-casts are a seasonal phenomenon that regularly deposits tons of algae biomass on beaches, which are usually disposed of in landfills. The present work aimed to contribute to the valorization of this biomass by studying bioactivities that reveal its potential in the pharmaceutical and/or cosmeceutical industries. Methanol and ethanol extracts and fractions from 15 beach-casts biomass were tested for a range of bioactivities. Eight of the most active samples exhibit IC50 values between 11.38 µg/mL and 19.28 µg/mL and selectivity indexes higher than 3.8, against NCI-H1299 (lung cancer) and T47D (breast cancer). Concerning antiaging potential, all the extracts tested presented UV protection, with SPF values above 30, like the standard sunscreen. Regarding aging-related enzymes, 24 samples were tyrosinase inhibitors exhibiting IC50 values from 9.01 µg/mL to 200.09 µg/mL. Eight extracts inhibited collagenase (IC50 < 248.76 µg/mL), two of them more actively than positive control EDTA (IC50 = 59.26 µg/mL). In addition to UV protection, the cumulative effect of antityrosinase and anticollagenase activities shown by the samples suggest that they may play a significant role in preventing skin photoaging. The results obtained demonstrate the high potential of beach-cast seaweed biomass as sources of cosmetic bioproducts with antiaging effects, and of selective cytotoxic metabolites.

show abstract

Section: Tyrosinase Inhibitionmentioning

confidence: 99%

Pharmacological and Cosmeceutical Potential of Seaweed Beach-Casts of Macaronesia

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Uncompetitive inhibitors bind to the enzyme-substrate complex, which changes its bioactivity [ 252 ]. Several peptides of algal origin have been shown to have chemical structures with the ability to act as enzymatic antagonists [ 3 , 9 , 253 , 254 , 255 , 256 ].…”

Section: Discussionmentioning

confidence: 99%

Seaweed Components as Potential Modulators of the Gut Microbiota

2021

View full text Add to dashboard Cite

Macroalgae, or seaweeds, are a rich source of components which may exert beneficial effects on the mammalian gut microbiota through the enhancement of bacterial diversity and abundance. An imbalance of gut bacteria has been linked to the development of disorders such as inflammatory bowel disease, immunodeficiency, hypertension, type-2-diabetes, obesity, and cancer. This review outlines current knowledge from in vitro and in vivo studies concerning the potential therapeutic application of seaweed-derived polysaccharides, polyphenols and peptides to modulate the gut microbiota through diet. Polysaccharides such as fucoidan, laminarin, alginate, ulvan and porphyran are unique to seaweeds. Several studies have shown their potential to act as prebiotics and to positively modulate the gut microbiota. Prebiotics enhance bacterial populations and often their production of short chain fatty acids, which are the energy source for gastrointestinal epithelial cells, provide protection against pathogens, influence immunomodulation, and induce apoptosis of colon cancer cells. The oral bioaccessibility and bioavailability of seaweed components is also discussed, including the advantages and limitations of static and dynamic in vitro gastrointestinal models versus ex vivo and in vivo methods. Seaweed bioactives show potential for use in prevention and, in some instances, treatment of human disease. However, it is also necessary to confirm these potential, therapeutic effects in large-scale clinical trials. Where possible, we have cited information concerning these trials.

show abstract

“…Because they contain vital nutrients like chelated microminerals, which are more readily available than both inorganic and organic minerals, as well as several kinds of complex carbohydrates with prebiotic supplement properties and health-promoting colouring agents, seaweeds are excellent substitutes for nutritional supplements for domesticated livestock. This plant like life produces 70% to 80% of oxygen in air through photosynthesis, and seaweeds is considered the lungs of ocean [11]. Seaweed extracts are excellent sources of essential nutrients such as N, P, K, Ca, and Mg as well as providing various organic components, trace elements and growth regulators for crop growth and production (Table 1) [12].…”

Section: Improves the Leaf Nutrient Contentmentioning

confidence: 99%

Deciphering Nature’s Secret of Seaweed Extract as a Biostimulant on Horticultural Crops: A Review

Tejasree,

Mirza,

Joka

2024

JEAI

View full text Add to dashboard Cite

Seaweed extracts have gained significant attention in horticultural practices due to their diverse range of beneficial effects on plant growth, development, and stress tolerance. The presence of antioxidants and Osm-protectants in seaweed extracts helps mitigate oxidative damage and maintain cellular integrity under adverse conditions. It also holds great promise as a valuable input in horticultural systems, offering a range of benefits including enhanced soil health, and sustainability. This review aims to summarize and analyze the benefits of seaweed extract application on horticultural crops. The extracts derived from seaweed are rich in essential nutrients which are available from through which plants can absorb easily and promote growth. It also contains numerous bioactive compounds including cytokinins, auxins, gibberellins, and betaines, which act as plant growth regulators. The application of seaweed extracts can induce systemic acquired resistance (SAR) in plants, triggering defense mechanisms against pathogens and pests, which can reduce the need for synthetic pesticides and fungicides, promoting sustainable and environmentally friendly horticultural practices. In addition to its direct effects on plants, seaweed extract enhances soil health and microbial activity. It serves as a natural biostimulant, promoting beneficial microbial populations in the rhizosphere, which facilitate nutrient uptake and cycling. Moreover, the humic substances present in seaweed extract contribute to soil structure improvement, water retention, and nutrient availability, fostering a conducive environment for plant growth.

show abstract

In Vitro Enzyme Inhibitory Properties, Secondary Metabolite Profiles and Multivariate Analysis of Five Seaweeds

Cited by 11 publications

References 29 publications

Pharmacological and Cosmeceutical Potential of Seaweed Beach-Casts of Macaronesia

Pharmacological and Cosmeceutical Potential of Seaweed Beach-Casts of Macaronesia

Seaweed Components as Potential Modulators of the Gut Microbiota

Deciphering Nature’s Secret of Seaweed Extract as a Biostimulant on Horticultural Crops: A Review

Contact Info

Product

Resources

About