In vitro enhancement of anticancer activity of paclitaxel by a Cremophor free cyclodextrin-based nanosponge formulation

Mognetti, Barbara; Barberis, Alessandro; Marino, Silvia; Berta, Giovanni Nicolao; Francia, Silvia De; Trotta, Francesco; Cavalli, Roberta

doi:10.1007/s10847-011-0101-9

Cited by 96 publications

(52 citation statements)

References 20 publications

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“…Cyclodextrin nanosponges (CD‐NSs) represent a further development in this field . Many drugs with different structures, solubility and pharmacological activities have been incorporated in nanosponges, including itraconazole, acyclovir, dexamethasone, doxorubicin, resveratrol, and tamoxifen . Particularly good results were obtained using CD‐NSs in the delivery of anticancer drugs such as paclitaxel and camptothecin .…”

Section: Methodsmentioning

confidence: 99%

Glutathione Bioresponsive Cyclodextrin Nanosponges

et al. 2015

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Cyclodextrin‐based nanosponges are designed as new nanostructured material for drug delivery. In vitro and in vivo studies show that nanosponges can increase the effectiveness of anti‐cancer drugs encapsulated within their nanostructure. Reported is a new, cheap glutathione (GSH)‐responsive material easily obtained in high yield through a one‐step synthetic route. Effectiveness of this GSH‐responsive material was proved using several tumor cells and doxorubicin as model anticancer drug. The release of the drug was in according with the GSH content in tumor cells.

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Section: Methodsmentioning

confidence: 99%

Glutathione Bioresponsive Cyclodextrin Nanosponges

et al. 2015

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“…The paclitaxel-loaded nanosponges formed a stable colloidal system in water inhibiting the recrystallization of paclitaxel over time. Moreover, this study demonstrated that delivery of paclitaxel via nanosponges increased the amount of paclitaxel entering cancer cells and lowered the IC 50 of paclitaxel, thereby enhancing its pharmacological effect [36]. …”

Section: Reviewmentioning

confidence: 99%

“…Acetylsalicylic acid (ASA), a nonsteroidal anti-inflammatory drug belonging to BCS class III, was formulated into pyromellitic dianhydride cross-linked β-cyclodextrin nanosponges [36]. TEM studies showed that the particle sizes of ASA-loaded nanosponges have average diameters ranging from 40 to 60 nm and they were seen to have a regular spherical shape.…”

Section: Reviewmentioning

confidence: 99%

Cyclodextrin-based nanosponges as drug carriers

Trotta¹,

Zanetti²,

Cavalli³

2012

Beilstein J. Org. Chem.

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292

219

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SummaryCyclodextrin-based nanosponges, which are proposed as a new nanosized delivery system, are innovative cross-linked cyclodextrin polymers nanostructured within a three-dimensional network. This type of cyclodextrin polymer can form porous insoluble nanoparticles with a crystalline or amorphous structure and spherical shape or swelling properties. The polarity and dimension of the polymer mesh can be easily tuned by varying the type of cross-linker and degree of cross-linking. Nanosponge functionalisation for site-specific targeting can be achieved by conjugating various ligands on their surface. They are a safe and biodegradable material with negligible toxicity on cell cultures and are well-tolerated after injection in mice. Cyclodextrin-based nanosponges can form complexes with different types of lipophilic or hydrophilic molecules. The release of the entrapped molecules can be varied by modifying the structure to achieve prolonged release kinetics or a faster release. The nanosponges could be used to improve the aqueous solubility of poorly water-soluble molecules, protect degradable substances, obtain sustained delivery systems or design innovative drug carriers for nanomedicine.

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“…The nanosponges were able to encapsulate both lipophilic and hydrophilic drugs and improve the solubility of poorly water-soluble molecules. For example, solid nanosponges with mean diameter lower than 500 nm and spherical shape were able to encapsulate paclitaxel up to 2 mg/ml, as an alternative to classical formulations in Cremophor EL [106]. Paclitaxel nanosponges were shown to be nonhemolytic and noncytotoxic.…”

Section: Incorporation Of Cds In Nanoparticulate Polymeric Systemsmentioning

confidence: 99%

Synthetic and Bioinspired Cage Nanoparticles for Drug Delivery

Deshayes

Gref

2014

Nanomedicine

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Nanotechnology has the potential to revolutionize drug delivery, but still faces some limitations. One of the main issues regarding conventional nanoparticles is their poor drug-loading and their early burst release. Thus, to overcome these problems, researchers have taken advantage of the host-guest interactions that drive some assemblies to form cage molecules able to strongly entrap their cargo and design new nanocarriers called cage nanoparticles. These systems can be classified into two categories: bioinspired nanosystems such as virus-like particles, ferritin, small heat shock protein: and synthetic host-guest supramolecular systems that require engineering to actually form supramolecular nanoassemblies. This review will highlight the recent advances in cage nanoparticles for drug delivery with a particular focus on their biomedical applications.

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In vitro enhancement of anticancer activity of paclitaxel by a Cremophor free cyclodextrin-based nanosponge formulation

Cited by 96 publications

References 20 publications

Glutathione Bioresponsive Cyclodextrin Nanosponges

Glutathione Bioresponsive Cyclodextrin Nanosponges

Cyclodextrin-based nanosponges as drug carriers

Synthetic and Bioinspired Cage Nanoparticles for Drug Delivery

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