In Vitro Effects on Thrombin of Paris Saponins and In Vivo Hemostatic Activity Evaluation of Paris fargesii var. brevipetala

Wen, Feiyan; Chen, Tiezhu; Yin, Hongxiang; Lin, Juan; Zhang, Hao

doi:10.3390/molecules24071420

Cited by 14 publications

(5 citation statements)

References 17 publications

(22 reference statements)

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“…However, Paris fargesii Franch is a sibling species of P. polyphylla var. yunnanensis and has a high saponin content (Wen et al, 2019). Therefore, it is important to isolate and identify symbiotic strains from P. fargesii Franch and screen them for the growth and accumulation of saponins to improve the growth rate of P. fargesii Franch.…”

Section: Introductionmentioning

confidence: 99%

Isolation and identification of symbiotic strains in Paris fargesii Franch that promote disease resistance

Yan

Wang²,

Xi³

et al. 2022

Front. Agron.

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Pairs polyphylla var. yunnanensis is a perennial herb, and its rhizomes are used as medicine to invigorate blood circulation, dissipate blood stasis, relieve swelling and pain, clear heat and detoxify the body. However, due to its slow growth, most of the saponin content is low, while the content of saponins is higher in Paris fargesii Franch of the same genus. The isolation and screening of strains from P. fargesii Franch that promote the accumulation of saponin content in P. polyphylla var. yunnanensis is important to improve the growth rate of artificially cultivated P. polyphylla var. yunnanensis and increase its medicinal activity. Plant symbiotic strains are biologically active microorganisms that can promote the growth and development of host plants through direct probiotic effects and indirect disease resistance mechanisms. Here, we isolated four strains of symbiotes, including two bacteria, Bacillus cereus (LgD2) and Bacillus thuringiensis (LgD10), and two fungi, Aspergillus tamari (TPD11) and Fusarium oxysporum (TPB). All of them promoted the biomass, chlorophyll content and photosynthetic efficiency of P. polyphylla var. yunnanensis seedlings to different degrees and effectively stimulated the accumulation of saponin content in P. polyphylla var. yunnanensis seedlings to improve the expression of saponin synthesis pathway genes. The symbiotes also promoted the enzymatic activities of the enzymes superoxide dismutase (SOD), peroxidase (POD), polyphenol oxidase (PPO) and phenylalanine aminolase (PAL), improved the physiological indicators of tobacco plants (plant height, crown width, leaf length and leaf width), reduced the incidence of tobacco black shank, and improved the growth and resistance-related genes of tobacco. In conclusion, the four symbiotic strains TPD11, TPB, LgD10 and LgD2 play an important role in regulating the growth, promoting saponin accumulation, and disease resistance of P. polyphylla var. yunnanensis.

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Section: Introductionmentioning

confidence: 99%

Isolation and identification of symbiotic strains in Paris fargesii Franch that promote disease resistance

Yan

Wang²,

Xi³

et al. 2022

Front. Agron.

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“…In additional, CCl4-induced hepatic fibrosis were significantly improved by polyphyllin D, polyphyllin G, polyphyllin VI, and formosanin C ( Man et al, 2014a ; Hong et al, 2016 ; Han et al, 2019 ). The mouse tail snipping model demonstrated that Paris saponin H, polyphyllin I, polyphyllin II, and polyphyllin VII could serve as favorable hemostatic agents ( Sun et al, 2014 ; Wen et al, 2019 ; Qiao et al, 2021 ). Polyphyllin V and polyphyllin VII showed powerful antibacterial activity against propionibacterium acnes ( Qin et al, 2012 ).…”

Section: Methods and Strategiesmentioning

confidence: 99%

“…According to a previous study, polyphyllin E inhibits ovarian cancer cells by downregulating the AKT/NF-κB pathway, reducing the expression of MMP2 and MMP9, and inhibiting the proliferation, migration, and invasion of ovarian cancer cells, thereby achieving an inhibitory effect in ovarian cancer cells (Liu Y. et al, 2022). In another study, polyphyllin H inhibited the growth of hepatoma cells and xenografts by suppressing the Wnt/β-catenin pathway, while knocking out of the β-catenin gene significantly inhibited this phenomenon (Chen T. et al, 2019). In addition, polyphyllin H-treated U251 human glioma cells had upregulated P21 and P27 expression and downregulated cyclin D expression, which further induced cell cycle arrest of U251 cells at the G1 phase.…”

Section: Antitumor Effects Of Other Active Ingredients In Rhizoma Par...mentioning

confidence: 96%

Therapeutic effects on cancer of the active ingredients in rhizoma paridis

Jia

Zhu

et al. 2023

Front. Pharmacol.

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Cancer is a major threat to human health, with high mortality and a low cure rate, continuously challenging public health worldwide. Extensive clinical application of traditional Chinese medicine (TCM) for patients with poor outcomes of radiotherapy and chemotherapy provides a new direction in anticancer therapy. Anticancer mechanisms of the active ingredients in TCM have also been extensively studied in the medical field. As a type of TCM against cancer, Rhizoma Paridis (Chinese name: Chonglou) has important antitumor effects in clinical application. The main active ingredients of Rhizoma Paridis (e.g., total saponins, polyphyllin I, polyphyllin II, polyphyllin VI, and polyphyllin VII) have shown strong antitumor activities in various cancers, such as breast cancer, lung cancer, colorectal cancer, hepatocellular carcinoma (HCC), and gastric cancer. Rhizoma Paridis also has low concentrations of certain other active ingredients with antitumor effects, such as saponins polyphyllin E, polyphyllin H, Paris polyphylla-22, gracillin, and formosanin-C. Many researchers have studied the anticancer mechanism of Rhizoma Paridis and its active ingredients. This review article describes research progress regarding the molecular mechanism and antitumor effects of the active ingredients in Rhizoma Paridis, suggesting that various active ingredients in Rhizoma Paridis may be potentially therapeutic against cancer.

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“…us, it has been widely used as a hemostatic medicine in China. A recent study demonstrated that Paris saponin H significantly enhanced thrombin activity, thereby shortening the bleeding time in the mouse tail snipping model, suggesting that Paris saponins could interact with thrombin [54]. Polyphyllin VII was found to act directly on platelets and hemostasis and cause 62% platelet aggregation at 300 ug/ml concentration [11].…”

Section: Antifibrosismentioning

confidence: 99%

Chemical Constituents and Pharmacological Activities of Steroid Saponins Isolated from Rhizoma Paridis

Liu

Tian

et al. 2021

Journal of Chemistry

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Rhizoma Paridis, the rhizome of liliaceous plants Paris polyphylla, is one of the most commonly used herbal drugs in China. Phytochemical and pharmacological studies have shown that steroid saponins were the major effective ingredients of Rhizoma Paridis to exert antitumor, anti-inflammatory, hemostasis, and antifibrosis functions. In this review, we discussed the chemical structures of steroid saponins and their related biological activity and mechanisms in cellular and animal models, aiming to provide a reference for future comprehensive exploitation and development of saponins.

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In Vitro Effects on Thrombin of Paris Saponins and In Vivo Hemostatic Activity Evaluation of Paris fargesii var. brevipetala

Cited by 14 publications

References 17 publications

Isolation and identification of symbiotic strains in Paris fargesii Franch that promote disease resistance

Isolation and identification of symbiotic strains in Paris fargesii Franch that promote disease resistance

Therapeutic effects on cancer of the active ingredients in rhizoma paridis

Chemical Constituents and Pharmacological Activities of Steroid Saponins Isolated from Rhizoma Paridis

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