In vitro Effects of Sulphydryl Agents on the Cortisol-Binding Capacity of the Rat Lens

Abstract

The authors have found that cysteine markedly increased the cortisol-binding capacity of the lens in vitro and that the oxidized form of glutathione acted as an inhibitor on the cortisol-binding capacity in the lens. The effect of exogenous sulphydryl group, especially cysteine, may have resulted from activation of endogenous sulphydryl groups as a bindingsite for cortisol.

Effect of Malnutrition on Cortisol-Binding Protein in the Lens of Cynomolgus Monkeys

“…The factors influencing the synthesis of cortisol-binding protein in the lens have been reported (2,3). However, it is still not clear how nutritional insuf fi ciency during early infancy affects the inactivation of cortisol in the lens of animals.…”