In vitro effects of propolis on Giardia duodenalis trophozoites

Freitas, Stella Fellipe de; Shinohara, Lina; Sforcin, José Maurício; Guimarães, Semíramis

doi:10.1016/j.phymed.2004.07.008

Cited by 104 publications

(83 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The positive effect of propolis on growth performance observed with V-line rabbit does could be attributed to its antibacterial (Scazzochio et al, 2006), antiviral (Gekker et al, 2005), antifungal (Dobrowolski et al, 1991 andSforcin et al, 2001), antiparasitic (Freitas et al, 2006), anti-inflammatory (Dobrowolski et al, 1991), immunomodulatory (Dimov et al, 1992) and antioxidant (Krol et al, 1990) effects.…”

Section: Discussionmentioning

confidence: 99%

Productive and reproductive performance of rabbits does as affected by bee pollen and/or propolis, inulin and/or mannan-oligosaccharides

et al. 2015

View full text Add to dashboard Cite

The aim of the paper was to compare the effect of prebiotics (inulin and/or mannan-oligosaccharides, MOS) and bee products (bee pollen and/or propolis) on productive and reproductive performance of rabbit does. Seventy nulliparous V-line female rabbits were distributed among 7 groups. The groups were fed the same diet and received no supplements (control group), natural molecules (bee pollen and/or propolis) at 200 mg/kg body weight (BW) or prebiotics (inulin and/or MOS) at 35 mg/kg BW. Productive, reproductive, biochemical and haematological traits were investigated. Bee pollen with propolis significantly increased body weight gain of does 1 wk after mating (3.53%), decreased feed intake (4.49%) and caused larger litter size (39.4%), heavier body weight of litter (17.7%), a greater number of kits born alive (48.7%), higher weight of kits (87.81%) at 28 d of age, higher milk yield (43.6%) and more favourable milk conversion ratio (31.6%). Moreover, bee pollen with propolis had significantly increased plasma total protein (43.1%), albumin (45.7%), globulin (41.0) and progesterone (60.5%), and had a significantly decreased plasma cholesterol (31.1%), aspartate aminotransferase/alanine aminotransferase ratio (20.3%) compared to the control group. Does treated with growth promoters had significantly fewer services per conception (22%) and greater fertility rate (21%) compared to the control group. Inulin with or without MOS significantly increased plasma glucose (49.9 and 50%, respectively) and feed cost (90.2%) compared to the control group. Supplementation of MOS or bee pollen with or without propolis had significantly greater relative economic efficiency (61.9, 55.1 and 27.1%, respectively) than the control group. MOS and bee pollen with or without propolis are able to improve productive and reproductive performance and economic efficiency of rabbit does in comparison to the unsupplemented group.

show abstract

Section: Discussionmentioning

confidence: 99%

Productive and reproductive performance of rabbits does as affected by bee pollen and/or propolis, inulin and/or mannan-oligosaccharides

et al. 2015

View full text Add to dashboard Cite

show abstract

“…[2,3,4,5,6]. This product has attracted the interest of researchers in recent decades because of the properties of biological and pharmacological, among others such as antimicrobial [7,8,9], antitumor [10], immunomodulator [11], anti-inflammatory [12], an antioxidant [13].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Studies of the Immunomodulator Effect of the Propolis Trigona spp. Extract in a Mouse Model

Kalsum¹

2017

IOSR JAVS

View full text Add to dashboard Cite

Propolis helps boost the immune system naturally because propolis is rich in bioactive compounds and can help increase the production and activity of immune cells. This product has attracted the interest of researchers in recent decades because of the properties of biological and pharmacological, among others such as antimicrobial, antitumor, anti-inflammatory, antioxidant and immunomodulatory. One of bee species that potentially produce propolis in Indonesia is a local bee species Trigona spp. This study aimed to to determine the immunomodulatory effects of ethanol extract of propolis on the Sprague Dawley rats were infected by Staphylococcus aureus. Identification of the phytochemical compounds was undertaken to determine the bioactive compounds contained in propolis liquid. The effects of propolis were analyzed using the macrophage activity as determined by the phagocytic activity and by the production of nitric oxide (NO) in Sprague Dawley rat peritoneal macrophages and the production of antibodies. The results showed that the liquid propolis produces (a) an increase in the phagocytic index, (b) a significant increase in NO production, and (c)

show abstract

“…This product has attracted researchers' interest in the last decade because of its numerous biological and pharmacological properties, such as antimicrobial (Sforcin et al, 2000;Freitas et al, 2006;Búfalo et al, 2009), antitumoral (Bazo et al, 2002), immunomodulatory (Sforcin, 2007), anti-inflammatory (Silva et al, 2012), antioxidant (Kumazawa et al, 2010), among others.…”

Section: Introductionmentioning

confidence: 99%

Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-κB and MAPK activation in macrophages

Búfalo

Ferreira

Costa

et al. 2013

Journal of Ethnopharmacology

152

102

View full text Add to dashboard Cite

Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-κB and MAPK activation in macrophages, Journal of Ethnopharmacology, http://dx.doi.org/ 10. 1016/j.jep.2013.06.004 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractEthnopharmacological relevance: Propolis is a bee product with numerous biological and pharmacological properties, such as immunomodulatory and anti-inflammatory activities.It has been used in folk medicine as a healthy drink and in food to improve health and prevent inflammatory diseases. However, little is known about its mechanism of action.Thus, the goal of this study was to verify the antioxidant activity and to explore the antiinflammatory properties of propolis by addressing its intracellular mechanism of action.Caffeic acid was investigated as a possible compound responsible for propolis action. Materials and Methods:The antioxidant properties of propolis and caffeic acid were evaluated by using the 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH) scavenging method. To analyze the anti-inflammatory activity, Raw 264.7 macrophages were treated with different concentrations of propolis or caffeic acid, and nitric oxide (NO) production, a strong pro-inflammatory mediator, was evaluated by the Griess reaction. The concentrations of propolis and caffeic acid that inhibited NO production were evaluated on intracellular signaling pathways triggered during inflammation, namely p38 mitogenactivated protein kinase (MAPK), c-jun NH 2 -terminal kinase (JNK1/2), the transcription nuclear factor (NF)-NB and extracellular signal-regulated kinase (ERK1/2), through Western blot using specific antibodies. A possible effect of propolis on the cytotoxicity of hepatocytes was also evaluated, since this product can be used in human diets.Results: Caffeic acid showed a higher antioxidant activity than propolis extract. Propolis and caffeic acid inhibited NO production in macrophages, at concentrations without cytotoxicity. Furthermore, both propolis and caffeic acid suppressed LPS-induced signaling pathways, namely p38 MAPK, JNK1/2 and NF-NB. ERK1/2 was not affected by propolis extract and caffeic acid. In addition, propolis and caffeic acid did not induce hepatotoxicity at concentrations with strong anti-inflammatory potential. Conclusions:Propolis exerted an antioxidant and anti-inflammatory action and caffeic acid may be involved in its inhibitory effects on NO production and intracellular signaling cascades, suggesting its use as a natural source of safe anti-inflammatory drugs.

show abstract

In vitro effects of propolis on Giardia duodenalis trophozoites

Cited by 104 publications

References 27 publications

Productive and reproductive performance of rabbits does as affected by bee pollen and/or propolis, inulin and/or mannan-oligosaccharides

Productive and reproductive performance of rabbits does as affected by bee pollen and/or propolis, inulin and/or mannan-oligosaccharides

Preliminary Studies of the Immunomodulator Effect of the Propolis Trigona spp. Extract in a Mouse Model

Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-κB and MAPK activation in macrophages

Contact Info

Product

Resources

About