In vitro effects of coronary angiography: Unknown clinical implications

Mansi, Ishak A.

doi:10.1016/j.mehy.2009.02.035

Cited by 2 publications

(2 citation statements)

References 47 publications

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“…These stimuli has proinflammatory effects such as increased endothelin and substance P and changes in platelet function such as increased release of thromboxane A2 and enhancement of platelet aggregation but the clinical importance is still unknown. [30][31][32] In our study, we could not explain whether CL is likely to be a flow-related phenomenon or an interaction between contrast medium and a dysfunctional endothelium or both. Intravascular ultrasound is a more sensitive tool than CAG and other methods for the evaluation of plaque morphology.…”

Section: Discussioncontrasting

confidence: 66%

Contrast Layering

Caglar

Demir

Çağlar³

et al. 2014

Angiology

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Patients with angiographically normal coronary arteries sometimes exhibit delayed clearance of contrast medium. This contrast layering (CL) was tested with intravascular ultrasound (IVUS) and markers of endothelial dysfunction and oxidative stress. The study group (n = 26) consisted of patients with CL and the control group (n = 32) comprised patients with normal coronary arteries despite angina symptoms. The CL was observed in 36 coronary arteries of 26 patients in the study group. Total antioxidant status and nitric oxide levels were significantly lower; total oxidant status, malondialdehyde plasma levels, and oxidative stress index were significantly higher in patients with CL than in controls. The IVUS studies revealed that atherosclerotic plaque burden, fibrous tissue, dense calcific tissue, and necrotic core ratios were significantly higher in the coronary segments with CL compared with adjacent normal segments. These results support the concept of CL as a new angiographic appearance of early atherosclerosis.

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Section: Discussioncontrasting

confidence: 66%

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Caglar

Demir

Çağlar³

et al. 2014

Angiology

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“…It is possible that the CM may have an effect on lymphocyte production or stimulation, in line with previous data that suggested a role for T-lymphocytes in delayed hypersensitivity to CM. [26][27][28][29] Haemoglobin In our study, we found that haemoglobin was significantly reduced at both 48 and 72 hours. This was probably due to haemodilution secondary to routine intravenous and oral rehydration following the procedure, 30 although our study design did not permit follow-up beyond 72 hours.…”

Section: Discussionsupporting

confidence: 53%

The effect of radiological contrast media on renal function and inflammatory markers in people with diabetes – a clinical study and review

2015

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Aim: To assess the association of inflammatory markers and the risk of developing contrast-induced nephropathy (CIN) in patients with diabetes undergoing lower limb angiography.Methods: This was a retrospective study of 77 patients undergoing lower limb angiography. We measured renal function and markers of inflammation, in particular neutrophil and lymphocyte count and C-reactive protein (CRP) levels, before and at 24, 48 and 72 hours after administration of contrast medium. Results: Those with pre-existing renal disease were at increased risk of CIN. We found no relationship between baseline renal function and CRP. There was a reduction in haemoglobin and lymphocyte count that is currently unexplained. Conclusions: While several traditional risk factors for CIN have been identified, further work is needed to determine the significance of changes in other haematological parameters. Br J Diabetes Vasc Dis 2015;15:187-191

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In vitro effects of coronary angiography: Unknown clinical implications

Cited by 2 publications

References 47 publications

Contrast Layering

Contrast Layering

The effect of radiological contrast media on renal function and inflammatory markers in people with diabetes – a clinical study and review

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