The effect of radiological contrast media on renal function and inflammatory markers in people with diabetes – a clinical study and review

Abstract

Aim: To assess the association of inflammatory markers and the risk of developing contrast-induced nephropathy (CIN) in patients with diabetes undergoing lower limb angiography.Methods: This was a retrospective study of 77 patients undergoing lower limb angiography. We measured renal function and markers of inflammation, in particular neutrophil and lymphocyte count and C-reactive protein (CRP) levels, before and at 24, 48 and 72 hours after administration of contrast medium. Results: Those with pre-existing renal disease were at increased risk of CIN. We found no relationship between baseline renal function and CRP. There was a reduction in haemoglobin and lymphocyte count that is currently unexplained. Conclusions: While several traditional risk factors for CIN have been identified, further work is needed to determine the significance of changes in other haematological parameters. Br J Diabetes Vasc Dis 2015;15:187-191

The Effects of Coenzyme Q10 on Contrast-Induced Acute Kidney Injury in Type 2 Diabetes: A Randomized Clinical Trial

“…On this basis, diabetes does not seem to be essentially a risk factor for CI-AKI unless accompanied with other factors (i.e., diabetic/chronic kidney disease or eGFR<30 mL/min/1.73 m 2 ). 33 34 35 Although the sensitivity to CI-AKI in healthy individuals and diabetic patients with preserved renal function are relatively equal, 36 37 our findings favor the notion that Q10 cannot prevent CI-AKI in the latter. A limited number of studies have evaluated the benefits of Q10 in CI-AKI in clinical settings.…”