In vitro effects of bisphenol A on the quality parameters, oxidative stress, DNA integrity and adenosine triphosphate content in sterlet (Acipenser ruthenus) spermatozoa

Hulák, Martin; Gazo, Ievgeniia; Shaliutina, Anna; Linhartova, Pavla

doi:10.1016/j.cbpc.2013.05.002

Cited by 75 publications

(49 citation statements)

References 43 publications

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“…SOD generally converts the superoxide anion radicals into hydrogen peroxide and water, and is the primary step of the antioxidant defense system. Similar to our findings, Hulak et al [17] reported increased SOD activities in the sterlet (Acipencer ruthenus) spermatozoa treated with BPA in vitro. The increases in the SOD activity could be due to superoxide anions [21].…”

Section: Discussionsupporting

confidence: 92%

Antioxidant defense system parameters in isolated fish hepatocytes exposed to bisphenol A — Effect of vitamin C

Kaya¹,

Kaptaner²

2016

Acta Biologica Hungarica

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In this study, isolated hepatocytes of pearl mullet (Alburnus tarichi) were exposed to bisphenol A (BPA) at concentrations of 25, 50, 100, and 200 µM for 24 h. Moreover, an in vitro antioxidant concentration of vitamin C (50 µM) was administrated to the culture medium along with the BPA exposures. Next, the antioxidant defense system parameters were analyzed. According to the results, the highest concentration of BPA (200 µM) proved to be severely toxic for the cells. The increased activities of superoxide dismutase (SOD) and glutathione-S-transferase (GST), the fluctuated activities of glutathione peroxidase (GPx), and the decreased content of reduced glutathione (GSH) were compared to the control group after the BPA exposures. Vitamin C co-administration was found to cause further increases in the SOD, GPx, and GST activities in some of the experimental groups and vitamin C could not restore the GSH content. Malondialdehyde (MDA) levels were observed to be unaffected in all exposure groups. These results show that BPA causes alterations in the antioxidant defenses of the isolated fish hepatocytes. In addition, vitamin C co-administration along with BPA was found to be non-protective against BPA-induced oxidative stress, consequently, aggravated a negative BPA impact.

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Section: Discussionsupporting

confidence: 92%

Antioxidant defense system parameters in isolated fish hepatocytes exposed to bisphenol A — Effect of vitamin C

Kaya¹,

Kaptaner²

2016

Acta Biologica Hungarica

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“…These oxidative responses were associated with spermatozoa quality depression, as measured by a decrease in the values of spermatozoa motility and velocity (106). Adverse effects of the monomer in male rats may be due to induction of oxidative stress in sperm (107).…”

Section: Mechanism(s) Of Action On Edcs Affecting the Male Reproductimentioning

confidence: 99%

Exposure to Endocrine Disrupting Chemicals and Male Reproductive Health

Jeng

2014

Front. Public Health

125

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Endocrine disrupting chemicals (EDCs) can interfere with normal hormonal balance and may exert adverse consequences on humans. The male reproductive system may be susceptible to the effects of such environmental toxicants. This review discusses the recent progress in scientific data mainly from epidemiology studies on the associations between EDCs and male reproductive health and our understanding of possible mechanisms associated with the effects of EDCs on male reproductive health. Finally, the review provides recommendations on future research to enhance our understanding of EDCs and male reproductive health. The review highlights the need for (1) well-defined longitudinal epidemiology studies, with appropriately designed exposure assessment to determine potential causal relationships; (2) chemical and biochemical approaches aimed at a better understanding of the mechanism of action of xenoestrogens with regard to low-dose effects, and assessment of identify genetic susceptibility factors associated with the risk of adverse effects following exposure to EDCs.

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“…It was observed that BPA, BPS and BPAF caused significant 628 damage to protein after 1 h incubation, whereas BPA, and BPS in 629 particular caused the most significant alterations in this parameter 630 after longer incubation time(Table 1). Damage to protein was also 631 observed byHulak et al (2013) in spermatozoa of sterlet (Acipenser ruthenus) exposed to BPA, while Abdel-Wahab (2014) showed that BPA strongly decreased total protein content and albumin content 634 in liver of male rats.Both BPA and BPAF induced significant increase in ROS level in…”

mentioning

confidence: 91%

Bisphenol A and its analogs induce morphological and biochemical alterations in human peripheral blood mononuclear cells (in vitro study)

Michałowicz

Mokra

Bak

2015

Toxicology in Vitro

103

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In vitro effects of bisphenol A on the quality parameters, oxidative stress, DNA integrity and adenosine triphosphate content in sterlet (Acipenser ruthenus) spermatozoa

Cited by 75 publications

References 43 publications

Antioxidant defense system parameters in isolated fish hepatocytes exposed to bisphenol A — Effect of vitamin C

Antioxidant defense system parameters in isolated fish hepatocytes exposed to bisphenol A — Effect of vitamin C

Exposure to Endocrine Disrupting Chemicals and Male Reproductive Health

Bisphenol A and its analogs induce morphological and biochemical alterations in human peripheral blood mononuclear cells (in vitro study)

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