Exposure to Endocrine Disrupting Chemicals and Male Reproductive Health

Jeng, Hueiwang Anna

doi:10.3389/fpubh.2014.00055

Cited by 125 publications

(89 citation statements)

References 105 publications

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“…Environmental factors (external and internal factors) like pollutants, global warming and exposure to environmental endocrine disruptors may affect integrity of sperm genome specially the sperm nuclear periphery where DNA is loosely bound to histones in the nuclohistone component (Jeng HA., 2014). Effects may be at different stages of the cell cycle such as during meiosis or spermiogenesis, and such abnormalities can have deleterious effects on offspring (Dinham and Malik, 2003).…”

Section: Discussionmentioning

confidence: 99%

Tobacco Use Increases Oxidative DNA Damage in Sperm - Possible Etiology of Childhood Cancer

Kumar

Chawla²,

Bisht³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Cigarette smoking and tobacco chewing are common modes of consuming tobacco all over the world. Parents need to be aware that germ cell integrity is vital for birth of healthy offspring as biological parenting begins much before birth of a child and even before conception. The present study was conducted to determine the etiology of non-familial sporadic heritable retinoblastoma (NFSHRb), by evaluating oxidative sperm DNA damage in fathers due to use of tobacco (smoking and chewing). Materials and Methods: We recruited 145 fathers of NFSHRb children and 53 fathers of healthy children (controls) in the study. Tobacco history was obtained by personal interview. Seminal reactive oxygen species (ROS) in semen, sperm DNA fragmentation index (DFI) and 8 hydroxy 2' deoxyguanosine (8-OHdG) levels in sperm were evaluated. The RB1 gene was screened in genomic blood DNA of parents of children with NFSHRb and controls. Odds ratios (ORs) derived from conditional logistic regression models. Results: There was significant difference in the levels of ROS (p<0.05), DFI (p<0.05) and 8-OHdG (p<0.05) between tobacco users and non-users. The OR of NFSHRb for smokers was 7.29 (95%CI 2.9-34.5, p<0.01), for tobacco chewers 4.75 (2.07-10.9, p<0.05) and for both 9.11 (3.79-39.2; p<0.01). Conclusions: This study emphasizes the adverse effect of tobacco on the paternal genome and how accumulation of oxidative damage in sperm DNA may contribute to the etiology of NFSHRb. In an ongoing parallel study in our laboratory, 11 of fathers who smoked underwent. Meditation and yoga interventions, showed significant decline in levels of highly mutagenic oxidised DNA adducts after 6 months. Thus our lifestyle and social habits impact sperm DNA integrity and simple interventions like yoga and meditation are therapeutic for oxidative damage to sperm DNA.

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Section: Discussionmentioning

confidence: 99%

Tobacco Use Increases Oxidative DNA Damage in Sperm - Possible Etiology of Childhood Cancer

Kumar

Chawla²,

Bisht³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Impairment in testicular function is also evident in other studies [23,24,25]. The efects of BPA resemble more or less the estrogenic efects on the testes [18, 26,27] with reduction in daily sperm production [28], deformed acrosomal vesicles, acrosomal caps, acrosomes and nuclei of the spermatids. Tohei et al [29] reported that plasma concentration of testosterone was decreased, and LH was increased in rats after administration of BPA.…”

Section: Efects On Reproductive Systemmentioning

confidence: 52%

Bisphenol A: Understanding Its Health Effects from the Studies Performed on Model Organisms

Ghosh¹,

Roy²,

Begum³

et al. 2017

Bisphenol a Exposure and Health Risks

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Bisphenol A [4,4′-(propane-2,2-diyl)diphenol] (abbreviated as BPA) is a synthetic xenoestrogenic chemical and endocrine disruptor. It is a most common plasticizer that is used widely to produce epoxy resin and polycarbonate plastics, enters the living system through food and water contamination and generates health hazards. Researches are being conducted to explore the adversity that BPA exerts in living body, and for this reason, model organisms are of scientiic choice. Rodents, zebraish, Drosophila, nematodes, crustaceans and echinoderms are being used for monitoring the efect of BPA on their life history traits, nervous system, endocrine system, reproductive systems, behaviour, etc., which could help us to anticipate what kind of challenges BPA is puting in human life. This systematic review is focused on the latest research trend on BPA toxicity on diferent model organisms.

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“…Sperm DNA integrity represents an essential requirement for the accurate transmission of genetic information. T h e r e i s l i m i t e d a n d c o n t r a d i c t o r y epidemiological evidence on whether endocrine disruptors affect human sperm DNA (14). These contradictions may be due to the different methodologies by which sperm DNA damage was characterized.…”

Section: Discussionmentioning

confidence: 99%

“…Endocrine disruptors as defined by the US Environmental Protection Agency, is an exogenous agent that interferes with the production, release, transport, metabolism, binding, action, or elimination of natural hormones in the body responsible for the maintenance of homeostasis and the regulation of developmental processes (11,12). Endocrine disruptors have been reported to decrease the AGD of male and female rats (13), impair sperm chromatin concentration and induce human sperm DNA damage (14). It is however not clear if these DNA damage is transmitted to successive generations.…”

Section: Introductionmentioning

confidence: 99%

Morphometric variables of offspring of <i>Quassia amara</i> treated male rats

Obembe¹,

Raji²

2017

Research Journal of Health Sciences

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Objective: Quassia amara is a medicinal plant with various pharmacological properties. The bioactive compound quassin is used as flavoring in food and beverages. Reproductive toxicological action of Q. amara is well documented but no information exists on its effect on prenatal programming. Methods:Adult male rats (180-200g, n=5) were treated daily (p.o) with Q. amara extract (100 mg/kg) for 6 weeks. A control group received distilled water. After 5 weeks of treatment, female rats were cohabited with the males for 7 days, at the ratio of 2:1. Mating was confirmed by presence of spermatozoa in all vaginal smear. Morphometric indices of all offspring were recorded on postnatal day one. They were also examined for any sign of abnormality or physical defect.Results: Fertility was zero in four out of the five treated rats. The females that cohabited with the fertile treated male gave birth to pups of varying sizes (6 and 9). However, four of the five control male rats were fertile and the female rats they mated had 9 pups each. No visible physical defect was observed on all offspring. Anogenital distance of the male offspring of the treated rats was significantly shorter than male offspring of the control, while anogenital distance of female offspring showed no statistical difference. Head diameter and body length were also significantly lower in offspring of the treated rats. However, weight, abdominal diameter and sex ratio of offspring were not statistically different. Conclusion:Quassia amara extract caused a reduction in the male anogenital distance, litter size, head diameter and body length of the offspring of treated male rats. Its reproductive toxicity actions may alter the developmental programming and probably transferred from one generation to another. Méthodes: Des rats mâles adultes (180-200g, n = 5) ont été traités quotidiennement (p.o) avec de l'extrait de Q. amara (100 mg / kg) pendant 6 semaines. Un groupe témoin a reçu de l'eau distillée. Après 5 semaines de traitement, les rats ont été cohabités avec les mâles pendant 7 jours, au ratio de 2: 1. L'accouplement a été confirmé par la présence de spermatozoïdes dans tous les frottis vaginaux. Les indices morphométriques de tous les descendants ont été enregistrés le premier jour post-natal. Ils ont également été examinés pour détecter tout signe d'anomalie ou de défaut physique. KeywordsRésultats: La fécondité était nulle sur quatre des cinq rats traités. Les femelles qui cohabitaient avec le mâle traité fertile ont donné naissance à des chiots de différentes tailles (6 et 9). Cependant, quatre des cinq rats mâles témoins étaient fertiles et les rats femelles qu'ils accouplaient avaient 9 chiots chacun. Aucun défaut physique visible n'a été observé chez tous les descendants. La distance anogenitale de la progéniture masculine des rats traités était significativement plus courte que la progéniture masculine du témoin, alors que la distance anogenitale de la progéniture féminine ne présentait aucune différence statistique. Le diamètre de la têt...

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Exposure to Endocrine Disrupting Chemicals and Male Reproductive Health

Cited by 125 publications

References 105 publications

Tobacco Use Increases Oxidative DNA Damage in Sperm - Possible Etiology of Childhood Cancer

Tobacco Use Increases Oxidative DNA Damage in Sperm - Possible Etiology of Childhood Cancer

Bisphenol A: Understanding Its Health Effects from the Studies Performed on Model Organisms

Morphometric variables of offspring of <i>Quassia amara</i> treated male rats

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