In Vitro Effect of Nonsteroidal Antiinflammatory Drugs on Proteoglycanase and Collagenase Activity in Human Osteoarthritic Cartilage

Vignon, E.; Mathieu, Pierre; Louisot, Pierre; Richard, Michel

doi:10.1002/art.1780341021

Cited by 47 publications

(17 citation statements)

References 9 publications

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“…The reduction in the net loss of PG produced by tenoxicam is quite consistent with a recent report (Vignon et al, 1992) showing that the proteoglycanase activity present in the cartilage of human OA femoral heads sampled at the time of total hip replacement was markedly reduced in the presence of this NSAID at a concentration of 4pgml-'. It remains to determine whether this suppressive effect of tenoxicam on the loss of PGs is due either to an inhibition of the production of superoxide anions (Minta & Williams, 1985), or to a reduction in the synthesis and/or activation of proteolytic enzymes or to a stimulation of the synthesis and secretion of tissue inhibitors of proteolytic enzymes (Dean, 1991).…”

Section: Discussionsupporting

confidence: 90%

Effects of tenoxicam and aspirin on the metabolism of proteoglycans and hyaluronan in normal and osteoarthritic human articular cartilage

Manicourt

Egeren

Haazen

et al. 1994

British J Pharmacology

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Section: Discussionsupporting

confidence: 90%

Effects of tenoxicam and aspirin on the metabolism of proteoglycans and hyaluronan in normal and osteoarthritic human articular cartilage

Manicourt

Egeren

Haazen

et al. 1994

British J Pharmacology

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“…In contrast to other NSAIDs, tenoxicam has a chondroprotective effect in human cartilage in vitro and may have beneficial effects. 27 The present study demonstrated considerable benefits with ia tenoxicam compared with the same dose administered iv in patients undergoing day case knee arthroscopy. The cost of 20 mg tenoxicam was $2.23 and was the same in both arms of the study as the same formulary was employed.…”

Section: Discussionmentioning

confidence: 54%

Intra-articular tenoxicam improves postoperative analgesia in knee arthroscopy

Colbert

Curran

O’Hanlon

et al. 1999

Can J Anesth/J Can Anesth

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Intra-articular tenoxicam improves postoperative analgesia in knee arthroscopyPurpose: Non Steroidal Anti-Inflammatory drugs have a well documented benef~ in the relief of postoperative pain. This study was designed to compare the analgesic effect of intra-articular tenoxicam 20 mg with intravenous tenoxicam on postoperative pain in 88 patients undergoing day case knee arthroscopy. Methods: A prospective, double blind, randomized trial was performed. All patients received a standard general anesthetic. Patients in group A received 20 mg tenoxicam made up to 40 ml with normal saline intra-articularly (io) and 2 ml normal saline iv. Patients in group B received 40 ml normal saline intra-articularly and 2 ml, 20 mg of tenoxicam, iv. Results: Both groups of patients were similar with respect to age, weight, sex and tourniquet inflation time. Patients receiving in tenoxicam had lower pain scores (at rest and upon movement) at 30, 60, 120 and 180 min postoperatively (0.8 _ 0.2 vs 2.5 _ 0.2 at rest and 1.24 _+ 0.2 vs 3.4 _+ 0.2 at movement at 60 min; P < 0.000 I). Fewer patients required additional analgesia in the first four hours postoperatively (33% vs 84%; P < 0.0000 I) and the time to first analgesia (23.7 + I 1.2 vs 9.4 _+ 0.6; P < 0.02) was longer in those receiving in tenoxicam. Conclusion: Intra-articular tenoxicam provides superior postoperative analgesia and reduces postoperative analgesic requirements compared with iv tenoxicam in patients undergoing day case knee arthroscopy.Objcctif: Les anti-inflammatoires non st&oi'diens sont des mddicaments bien reconnus pour le soulagement de la douleur postop&atoire. La pr&ente ~tude avait pour but de comparer reffet analg&ique de 20 mg de t6noxi-cam intra-articulaire ~ du t~noxicam intraveineux sur la douleur postop&atoire chez 88 patients admis en chirurgie ambulatoire pour une arthroscopie du genou. M&hode : On a proc6d~ ~ un essai prospectif, randomis6 et ~ double insu. Tous les patients ont re~u un anesth&ique g~n&al standard. Les patients du groupe A ont re~u une injection intra-articulaire (io) compos& de 20 mg de t~noxicam compl6t~ ~ 40 ml par une solution salve et 2 ml de solution sal& iv. Les patients du groupe B ont re~u 40 ml de solution sal& en injection intra-articulaire et 2 ml, 20 mg de t~noxicam, iv. R~sultats : Les deux groupes pr6sentaient des caract&istiques semblables quant ~ I'~ge, le poids, le sexe et le temps de gonflement du garrot. Les patients qui ont re~u du tfinoxicam io ont eu des scores de douleur plus bas (au repos et en mouvement) ~ 30, 60, 120 et 180 min apr~s I'intervention (0,8 + 0,2 vs 2,5 -0,2 au repos et 1,24 _+ 0,2 vs 3,4 _+ 0,2 en mouvement ~ 60 min; P < 0,0001). Moins de patients ont eu besoin d'analg&ie suppl~mentaire pendant les quatre premi&es heures postop&atoires (33 % vs 84 %; P < 0,0000 I) et le temps &oul~ avant la premi&e analg&ie (23,7 _+ I 1,2 vs 9,4 _+ 0,6 P < 0,02) a ~t~ plus long pour les patients qui ont re~u du t~noxicam in. Conclusion : Le t6noxicam intra-articulaire, compar~ au t~noxicam iv, fournit une anal...

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“…Until now, only 2 studies have investigated the influence of diclofenac on the cartilage metabolism of the knee, and both demonstrated that diclofenac did not induce any degenerative processes (in an animal and an in vitro study) (23, 24). However, in a study by Vignon et al (25), a slightly decreased proteoglycanase activity was observed in human OA cartilage of the hip. However, those studies did not investigate the influence of diclofenac on cartilage metabolism of the hip or the knee joint simultaneously, and therefore it remains unclear how diclofenac acts on the knee or the hip joint.…”

Section: Discussionmentioning

confidence: 86%