In vitro effect of cinnamic aldehyde, a main component of Cinnamomi Cortex, on human platelet aggregation and arachidonic acid metabolism.

Takenaga, Mitsuko; Hirai, Aizan; Terano, Takashi; Tamura, Yasushi; Kitagawa, Haruo; Yoshida, Sho

doi:10.1248/bpb1978.10.201

Cited by 27 publications

(16 citation statements)

References 13 publications

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“…Concerning the mechanisms of these vasoprotective effects, keishibukuryogan is reported to exert an improvement effect on hemorheological factors 9,12) as well as an anti-oxidant effect. 13) As part of this formula, Cinnamomi Cortex is thought to have various effects on anti-platelet aggregation, 5,6) inhibition of thromboxane A2, 14) to have a vasorelaxation effect, 7) and so on. As mentioned above, there are many reports concerning the effects of Cinnamomi Cortex on blood circulation, but there is no report about the effect of cinnamaldehyde on vasomotion.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, in oriental medicine, Cinnamomi Cortex is often used to improve blood circulation. In regard to the circulatory system, a catecholamine-releasing effect of cinnamaldehyde, 4) a reducing effect on platelet aggregation due to suppression of the release of arachidonic acid from platelets, 5) and an inhibitory effect of collagen-induced platelet aggregation 6) have been reported. However, reports concerning the direct effect against vasomotion by components of Cinnamomi Cortex are few, except in relation to cinnamtannin.…”

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confidence: 99%

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Cinnamaldehyde Induces Endothelium-Dependent and -Independent Vasorelaxant Action on Isolated Rat Aorta

Yanaga

Goto

Nakagawa

et al. 2006

Biological & Pharmaceutical Bulletin

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Animals Male Wistar rats weighing 370-420 g were purchased from Japan SLC (Shizuoka, Japan). They were kept in an animal room at an ambient temperature of 23Ϯ1°C under a 12-h dark-light cycle. Experimental protocols met the "Guidelines for Animal Experimentation" approved by the Japanese Association of Laboratory Animal Science and the Japanese Pharmacological Society.Preparation of Rat Aorta Rats were anesthetized (50 mg/kg i.p. pentobarbital) and sacrificed by cutting their abdominal aorta. Fats and connective tissues were removed from a section of the thoracic aorta, and 3-mm-wide aortic rings were prepared. For an endothelium-free aorta, the endothelial lining of each ring was removed by pressing the ring and rolling it gently onto a filter paper a few times. The endothelium was considered to be intact when relaxation induced by 1 mM of acetylcholine was over 20% of the maximal tension obtained by 60 mM KCl-induced contraction, and the removal of the endothelium was confirmed by the absence of acetylcholine-induced relaxation.Vasodilative Effect of Cinnamaldehyde on Isolated Aortic Rings The aortic rings were mounted on steel hooks in a Magnus chamber (Kishimoto UC-5TD, Kyoto, Japan). One end of the aorta was attached to a force-displacement transducer (Kishimoto UM-203) so that its isometric contraction could be recorded (NEC RECTI-HORIZ-8K, Tokyo, Japan). The baths were filled with 5 ml of Krebs solution containing the following (mM): NaCl 120, KCl 4.7, NaHCO 3 25.0, KH 2 PO 4 1.2, MgSO 4 · 7H 2 O 1.2, CaCl 2 2.5, and glucose 10.0. The solution was maintained at 37°C and bubbled continuously with 5% CO 2 in O 2 at pH 7.4. The rings were equilibrated for 45 min at an initial resting tension of 1 g. During this period, the Krebs solution in the bath was

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Cinnamaldehyde Induces Endothelium-Dependent and -Independent Vasorelaxant Action on Isolated Rat Aorta

Yanaga

Goto

Nakagawa

et al. 2006

Biological & Pharmaceutical Bulletin

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“…1) The versatile biomedical effects of CNMD, EL and PL have been intensively investigated, for example, anti-aggregation of platelet, 2) antimutagenic 3,4) and bacteriocidal [5][6][7][8] effects. A protective effect on ischemia and the antilipid peroxidation effect of PL were reported.…”

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confidence: 99%

Simultaneous Determination of Cinnamaldehyde, Eugenol and Paeonol in Traditional Chinese Medicinal Preparations by Capillary GC-FID

Lai

Tan

2006

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…[10][11][12][13][14][15][16][17][18][19] One major limitation of cancer chemotherapy is the toxicity of anticancer drugs. An approach to limiting toxicity of drugs to normal tissues is to attach the drug to a carrier system capable of targeting tumor cells, such as that provided by monoclonal antibody.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 9-Bromo-2-fluoro-6,7-dihydro-5H-benzocycloheptene-8-carboxaldehyde

Silveira

Templet

Fronczek

2009

Synthetic Communications

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Cinnamaldehye is an antioxidant shown to induce apoptotic cell death in a number of human cancer cells. This article reports a synthesis of 9-bromo, 2-fluoro substituted, and Z-ring locked (by a trimethylene bridge at C-8 and C-11) crystalline fluorine-substituted derivative of cinnamaldehyde. The synthon, 8-fluoro-1-benzosuberone was treated with PBr 3 , dimethylformamide (DMF), and CHCl 3 as a solvent to obtain 9-bromo-2-fluoro-6,7-dihydro-5H-benzocycloheptene-8-carboxaldehyde. The one-step trifunctionalization process converts a bicyclic ring-fused ketone into a b-bromo-a,b-unsaturated aldehyde in a chemoselective and regioselective manner. The process also creates a new carboncarbon bond between C-8 and C-12. The structure of the previously unreported product has been obtained by x-ray crystallographic analysis. It has been characterized spectroscopically by infrared (IR), 1 H NMR, 13 C NMR, gas chromatography-mass spectrometry (GC-MS), and elemental analysis. It is a structural element found in sterically hindered retinoids and is a useful advanced intermediate in the total synthesis of these naturally occuring bioactive polyenes.

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In vitro effect of cinnamic aldehyde, a main component of Cinnamomi Cortex, on human platelet aggregation and arachidonic acid metabolism.

Cited by 27 publications

References 13 publications

Cinnamaldehyde Induces Endothelium-Dependent and -Independent Vasorelaxant Action on Isolated Rat Aorta

Cinnamaldehyde Induces Endothelium-Dependent and -Independent Vasorelaxant Action on Isolated Rat Aorta

Simultaneous Determination of Cinnamaldehyde, Eugenol and Paeonol in Traditional Chinese Medicinal Preparations by Capillary GC-FID

Synthesis of 9-Bromo-2-fluoro-6,7-dihydro-5H-benzocycloheptene-8-carboxaldehyde

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