In vitro effect of AlCl3 on human erythrocytes: Changes in membrane morphology and functionality

Lukyanenko, Ludmila Michaylovna; Skarabahatava, Aliasksandra Sergeevna; Slobozhanina, E. I.; Kovaliova, Svetlana A.; Falcioni, Maria Letizia; Falcioni, Giancarlo

doi:10.1016/j.jtemb.2012.10.003

Cited by 29 publications

(24 citation statements)

References 49 publications

(49 reference statements)

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“…Lipid peroxidation of cell membrane can result in the inactivation of enzymes and can cause disorder of cross-linking between membrane lipids and proteins, and thereby, leads to the dysfunction of membrane [56][57][58]. In our study, the reduced SOD, CAT, and GSH-pX activities and the increased MDA content prove that AlCl 3 induces oxidative [29]. Both results suggest that AlCl 3 induces oxidative stress and suppresses antioxidative capacity in circulating blood.…”

Section: Discussionsupporting

confidence: 61%

“…Several studies reported that Al damages the molecular structure, deformability, and fluidity of erythrocyte membrane by inducing lipid peroxidation and oxidative stress [27,[29][30][31]. Moreover, Suwalsky et al found that Al disorders the ion balance between intracellular and extracellular, which affects the transport function of membrane [32].…”

Section: Introductionmentioning

confidence: 99%

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Aluminum Trichloride Induces Hypertension and Disturbs the Function of Erythrocyte Membrane in Male Rats

Zhang

Cao

Sun

et al. 2015

Biol Trace Elem Res

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Aluminum (Al) is the most abundant metal in the earth's crust. Al accumulates in erythrocyte and causes toxicity on erythrocyte membrane. The dysfunction of erythrocyte membrane is a potential risk to hypertension. The high Al content in plasma was associated with hypertension. To investigate the effect of AlCl3 on blood pressure and the function of erythrocyte membrane, the rats were intragastrically exposed to 0, 64(1/20 LD50), 128(1/10 LD50), and 256(1/5 LD50) mg/kg body weight AlCl3 in double distilled water for 120 days, respectively. Then, we determined the systolic and mean arterial blood pressures of rats, the osmotic fragility, the percentage of membrane proteins, the activities of Na(+)/K(+)-ATPase, Mg(2+)-ATPase, Ca(2+)-ATPase, catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-pX), and malondialdehyde (MDA) content of the erythrocyte membrane in this experiment. The results showed that AlCl3 elevated the systolic and mean arterial blood pressure of rats, increased the osmotic fragility, decreased the percentage of membrane protein, inhibited the activities of Na(+)/K(+)-ATPase, Mg(2+)-ATPase, Ca(2+)-ATPase, CAT, SOD and GSH-pX, and increased the MDA content of erythrocyte membrane. These results indicate that AlCl3 may induce hypertension by disturbing the function of erythrocyte membrane.

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Aluminum Trichloride Induces Hypertension and Disturbs the Function of Erythrocyte Membrane in Male Rats

Zhang

Cao

Sun

et al. 2015

Biol Trace Elem Res

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“…DPH and TMA-DPH were incorporated, according to partition equilibrium, in the hydrophilic layer at the membrane surface (TMA-DPH) and the hydrophobic core of the lipid bilayer (DPH). Steady-state florescence anisotropy of TMA-DPH reflected the packing of membrane lipid fatty acid chains and an increase in TMA-DPH anisotropy indicated a reduction in membrane fluidity in the region of the bilayer where the probe was incorporated (Grebowski, Krokosz, & Puchala, 2013;Lukyanenko et al, 2013).…”

Section: Effect Of Grape Pomace Extracts On Membrane Fluiditymentioning

confidence: 99%

Antioxidant comparative effects of two grape pomace Mexican extracts from vineyards on erythrocytes

et al. 2016

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“…The target tissues for loading aluminum are bone, brain, kidney, and liver. The signs and symptoms of Al toxicity include: neurodegenerative diseases [4], hematological abnormalities [5] and liver damage [6]. It also caused oxidative stress and an increase in lipid peroxidation [7].…”

Section: Introductionmentioning

confidence: 99%

Effect of Grapefruit Juice on Aluminum-Induced Hepatotoxicity in Albino Rats: Histological, Ultrastructural and Histochemical Assessment

Al-Amoudi¹

2017

ABB

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The present work studied the effect of grapefruit juice (Citrus) on the hepatotoxicity of AlCl 3 . Four groups of adult male albino rats were used. Group I contained 10 rats and remained as a control group; Group II: 10 rats were included and orally administered with grapefruit juice at a dose level of 27 ml/kg of body weight per day for 6 weeks; Group III: 10 rats were included and AlCl 3 was administered orally at a dose level of 100 mg/kg of body weight per day for 6 weeks; Group IV: animals of this group (10 rats) were given a combination of AlCl 3 and grapefruit juice per day for 6 weeks. At the end of the sixth week, the liver was processed for histological and ultrastructure studies. In addition, ALT and AST were determined in blood sera. The results showed that AlCl 3 induced several histological alterations in the liver, including congestion of blood vessels, leucocytic infiltration, cytoplasmic vacuolation of hepatocytes and fatty infiltrations. Ultrastructural changes include the degeneration of mitochondria, RER swelling and pyknosis of the nuclei with an increase in fat droplets and lysosomes. The biochemical results showed an increase in ALT and AST activities in the AlCl 3 group. However, the group of rats treated with AlCl 3 and grapefruit juice improved the histological and ultrastructural changes, while the levels of ALT and AST were reduced. It was concluded in the results that grapefruit juice has a protective effect against hepatotoxicity of AlCl 3 that can be attributed to the antioxidant properties of its components.

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In vitro effect of AlCl3 on human erythrocytes: Changes in membrane morphology and functionality

Cited by 29 publications

References 49 publications

Aluminum Trichloride Induces Hypertension and Disturbs the Function of Erythrocyte Membrane in Male Rats

Aluminum Trichloride Induces Hypertension and Disturbs the Function of Erythrocyte Membrane in Male Rats

Antioxidant comparative effects of two grape pomace Mexican extracts from vineyards on erythrocytes

Effect of Grapefruit Juice on Aluminum-Induced Hepatotoxicity in Albino Rats: Histological, Ultrastructural and Histochemical Assessment

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