In-vitro dissolution and microbial inhibition studies on anticancer drug etoposide with β-cyclodextrin

Arumugam, Shanmuga Priya; Balakrishnan, Suganya Bharathi; Ganesan, Vigneshkumar; Maniyazagan, Munisamy; Kuppu, Sakthi Velu; Narayanan, Vimalasruthi; Vaseeharan, Baskaralingam; Sivakamavalli, Jeyachandran; Stalin, T.

doi:10.1016/j.msec.2019.04.033

Cited by 25 publications

(2 citation statements)

References 49 publications

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“…The characteristic diffraction peaks of diuron had almost disappeared in the inclusion complex, which might be due to the formation of inclusion complexes by diuron in the β -CD cavity, and which could be mutually corroborated with the SEM image [23]. From the results of the XRD patterns, strong evidence for the solid inclusion complex of diuron with β -CD was provided [24].…”

Section: Resultsmentioning

confidence: 71%

Enhanced Solubility, Stability, and Herbicidal Activity of the Herbicide Diuron by Complex Formation with β-Cyclodextrin

et al. 2019

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The herbicide diuron is hardly soluble in water and most organic solvents and is usually made into a wettable powder or mixed with soil when used, which causes environmental risk and a reduction in herbicidal efficacy. In this study, the physicochemical properties were changed by using β-cyclodextrin (β-CD) to encapsulate diuron to form an inclusion complex. Some key technologies, including X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and nuclear magnetic resonance (1H NMR), were used to characterize the inclusion complex. The stoichiometry of the inclusion complex was determined by recording the 1H NMR spectrum or by using a diagram of inclusion ratios. A phase solubility study proved that the formed inclusion complex exhibited higher water solubility. Thermogravimetric analysis (TGA) demonstrated that the formed inclusion complex exhibited better thermal stability. Biological activity studies indicated that the herbicidal activity, in terms of herbicide removal, of the formed inclusion complex was higher than that of the original diuron. In general, the formation of the inclusion complex could reduce the environmental damage caused by diuron and enhance its herbicidal activity, providing an environmentally friendly method for using diuron.

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Section: Resultsmentioning

confidence: 71%

Enhanced Solubility, Stability, and Herbicidal Activity of the Herbicide Diuron by Complex Formation with β-Cyclodextrin

et al. 2019

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“…As the quote above, inclusion complex formation with HPβ-CD could increase into contact with microorganisms when it was dispersed in aqueous solutions leading to enhanced antimicrobial activity at lower concentrations of encapsulated compounds. [56][57][58][59][60][61] As the primitive sites for antimicrobial action were found at the cell membrane and inside the cytoplasm, HPβ-CD may enhance the accession of PA to these regions by improving the water solubility of PA.…”

Section: Molecular Docking Studiesmentioning

confidence: 99%

Nanofibers from hydroxypropyl β-cyclodextrin/pantothenic acid supramolecular complexes: Physicochemical characterization and potential biomedical applications

Mohandoss

Palanisamy

You

et al. 2022

Journal of Industrial Textiles

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The electrospinning of nanofibers (NFs) from 2-hydroxypropyl β-cyclodextrin supramolecular inclusion complexes (150% HPβ-CD, w/v) with vitamin B5 (pantothenic acid [PA]) was achieved without using any carrier polymeric matrix. The presence of PA and the formation of the HPβ-CD/PA inclusion complex within the NFs structure were confirmed by SEM, FTIR, XRD, and TGA analysis. SEM images depicted the bead-free uniform NFs and confirmed the incorporation of HPβ-CD/PA NFs did not alter the fiber morphology having an average fiber diameter of 512 ± 24 nm, 328 ± 18 nm, and 150 ± 19 nm, respectively. Fourier transform infrared (FTIR) spectrum indicated inclusion complex from the shifting of the peaks of each component in HPβ-CD/PA NFs, whereas XRD pattern revealed that HPβ-CD/PA NFs was achieved due to the formation of a new amorphous structure. TGA studies showed that the stability of PA after HPβ-CD encapsulation was improved. Molecular docking was used to simulate the positions and interactions of the binding sites of the HPβ-CD/PA inclusion complex. The phase solubility test showed enhanced solubility of PA due to the inclusion complexation; in addition, the stoichiometry of HPβ-CD/PA was determined to be 1:1. The release of PA from HPβ-CD/PA NFs prevented the colonization of Escherichia coli (5.0 ± 0.3%) and Staphylococcus aureus (2.0 ± 0.5%) bacteria to a great extent, as observed in the antibacterial activity results. The cell viability of HCT-116 cells treated with 100 μg/mL of HPβ-CD/PA NFs was registered at 97.5 ± 2.1%. It was observed that HPβ-CD/PA NFs had higher anticancer activity compared to pure PA and HPβ-CD due to the solubility increase. In brief, our results suggested that polymer-free HPβ-CD/PA inclusion complex NFs could have potential applications in food, pharmaceuticals, and healthcare thanks to its efficient antibacterial and anticancer activities.

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Laccase-Assisted Degradation of Anticancer Drug Etoposide: By-Products and Cytotoxicity

et al. 2023

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In-vitro dissolution and microbial inhibition studies on anticancer drug etoposide with β-cyclodextrin

Cited by 25 publications

References 49 publications

Enhanced Solubility, Stability, and Herbicidal Activity of the Herbicide Diuron by Complex Formation with β-Cyclodextrin

Enhanced Solubility, Stability, and Herbicidal Activity of the Herbicide Diuron by Complex Formation with β-Cyclodextrin

Nanofibers from hydroxypropyl β-cyclodextrin/pantothenic acid supramolecular complexes: Physicochemical characterization and potential biomedical applications

Laccase-Assisted Degradation of Anticancer Drug Etoposide: By-Products and Cytotoxicity

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