In vitro digestion/Caco-2 cell model to estimate cadmium and lead bioaccessibility/bioavailability in two vegetables: The influence of cooking and additives

Fu, Jin; Cui, Yanshan

doi:10.1016/j.fct.2013.06.014

Cited by 106 publications

(86 citation statements)

References 53 publications

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“…With respect to pak choi, the average bioaccessibility values for Cd, Pb and As were 71%, 48% and 37% in the gastric fraction, whereas the bioaccessibility values for the gastrointestinal fraction were 29%, 30.5% and 52.5%, respectively. These present results were higher or similar to metal(loid) bioaccessibility from vegetables reported by Hu et al [25] and Fu and Cui [26]. Compared with the values in several types of raw vegetables by Zhuang et al [17], the average bioaccessibility for the gastric and gastrointestinal fractions were similar, in which Pb bioaccessibility varied from 10 to 60% in the gastric phase and from 13 to 39% in the gastrointestinal phase.…”

Section: Resultssupporting

confidence: 84%

“…In China, metal(loid) contaminated rice and vegetables produced in the polluted soils around mining-impacted areas are sold at the markets all over the country, resulting in great human health risk for the consumers, which are not restricted to the polluted area [2,26]. Given the situation of contaminated rice and vegetables, the health risk of Pb and Cd poisoning is the greatest for people who eat rice and vegetables several times a day, however eating less rice or vegetables is not an option in many parts of the world, where it is an irreplaceable part of culture, diet and lifestyle.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Oral Bioaccessibility and Exposure Risk of Metal(loid)s in Local Residents Near a Mining-Impacted Area, Hunan, China

Zhuang

Sun

et al. 2018

IJERPH

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Metal(loid) contamination of food crops and soils resulting from mining activities has been a major concern due to the potential risk to humans. In this study, a total of 36 rice (home-grown and market rice), 38 vegetable, 10 drinking water, 4 river water, 18 soils and 30 urine samples were collected from an abandoned mining area or the local residents in China. Results showed that metal(loid) levels in some of the soil and drinking water samples exceeded the Chinese standard. Rice Cd concentration, rice Pb levels, and vegetable Pb levels exceeded the maximum permissible concentrations in 49%, 68%, and 42% of the samples, respectively. In gastric phases, the average Cd, Pb and As bioaccessibilities in rice were 72%, 70%, and 82%. In gastrointestinal phases, the average Cd, Pb and As bioaccessibilities in rice were 49%, 39%, and 94%. Vegetables (pak choi was selected) showed lower metal(loid) bioaccessibility than rice. The median concentrations of Cd, Pb and As in urine were 3.99, 4.82 and 64.8 µg L−1, respectivley. Rice had the highest contribution rates of Cd and Pb for daily intake, accounting for 114% and 210%, respectively. Vegetables contributed less, and very little contribution came from drinking water. Based on the bioaccessibility data, metal(loid) contamination around the mining area poses a great exposure risk to the local residents through consumption of food crops.

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Section: Resultssupporting

confidence: 84%

Section: Resultsmentioning

confidence: 99%

Oral Bioaccessibility and Exposure Risk of Metal(loid)s in Local Residents Near a Mining-Impacted Area, Hunan, China

Zhuang

Sun

et al. 2018

IJERPH

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show abstract

“…Fu and Cui [20] also verified the bio-accessibility for lead and cadmium in vegetables and evaluated the differences in the gastric and intestinal phases from raw and cooked food. They found that cadmium is more bioavailable in the gastric phase.…”

Section: Discussionmentioning

confidence: 99%

“…The concentration of PTEs in foods is not proportional to the bio-accessible concentration [20]. The fraction of a contaminant that is released from the food matrix into the digestive fluid and is, therefore, available for intestinal absorption is the bio-accessible fraction of that component [7].…”

Section: Introductionmentioning

confidence: 99%

Lead, Cadmium, and Arsenic Bioaccessibility of 24 h Duplicate Diet Ingested by Preschool Children Attending Day Care Centers in Brazil

Leroux

Ferreira

Paniz

et al. 2018

IJERPH

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Lead, known as a metal with high neurotoxicity to children, cadmium, which is a carcinogenic and bioaccumulative contaminant, and arsenic, a class 1 carcinogenic according to the International Agency for Research on Cancer, are toxic elements (TEs) whose relevant route of exposure may be diet. We determined the bio-accessible fraction of lead, cadmium, and arsenic from the diet of preschool children from two day care centers (DCC). A cross-sectional study was conducted with 64 one–four-year-old children from two DCCs where the 24-h duplicate diet samples were collected. The diet samples were analyzed by ICP-MS for lead, cadmium, and arsenic total concentrations (n = 64) and their bio-accessibility were analyzed for a subsample (n = 10). The dietary intake (DI) mean for lead, cadmium, and arsenic were 0.18 ± 0.11 µg kg−1 bw, 0.08 ± 0.04 µg kg−1 bw, and 0.61 ± 0.41 µg kg−1 bw, respectively. All DI calculated for TEs, considering total intake, were found lower than the tolerable limits (TL) (European Union, or World Health Organization, WHO, when applicable) except for one child’s Pb intake. Bio-accessibilities ranged between 0% to 93%, 0% to 103%, and 0% to 69%, for lead, cadmium, and arsenic, respectively. Although DI for TEs has been found lower than TL, these reference values have been recently decreased or withdrawn since it was for lead and arsenic whose TL were withdrawn by WHO.

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“…As for DHS and CHS, there were statistically signifi cant differences between all pairs of comparison except for T1 and T2. The variation in metal bioavailabilities between the gastric and the intestinal extraction may be due to the chemical form of the metals, metal species, gastrointestinal tract contents, diet, nutritional status, microfi bers of crystalline cellulose and phytates, phytochelatins, and vegetable species [110]. Furthermore, the metal bioaccessibilities may be affected by simulated parameters such as gastric and small intestinal pH and chemistry, gastric mixing, and gastric emptying rates [111].…”

Section: CDmentioning

confidence: 99%

Mn- and Cd-Contaminated Wild Water Spinach: in vitro Human Gastrointestinal Digestion Studies, Bioavailability Evaluation, and Health Risk Assessment

Guan¹,

Mohamat-Yusuff²,

Halimoon³

et al. 2018

Pol. J. Environ. Stud.

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Human health may be at risk when consuming edible but metal-contaminated aquatic plants. This present study was conducted to evaluate the bioavailabilities of manganese (Mn) and cadmium (Cd) in metalscontaminated wild water spinach (WWS), Ipomoea aquatic Forssk. through in vitro human gastrointestinal digestions. Additionally, the health risks from consuming the plant were also assessed. Metals-contaminated hydroponic nutrient solutions were used to grow the plants under greenhouse conditions. The plants were harvested after seven days of metal exposure and their edible shoots (stems and leaves) underwent digestions simulated from the human gastrointestinal tract. A standard reference material (peach leaves, SRM 1547) was used to assess the precision and accuracy of the in vitro digestion studies. Results showed that the metal concentrations in plants increased when the treatment concentration increased; the metals concentrations were higher in the raw (RHS) samples than in the cooked (DHS and CHS) samples. The bioavailabilities of Mn and Cd were found to be higher in the intestinal extractions than in the gastric extractions. The health risk index (HRI) showed that the adults averagely aged 44 in Selangor, Malaysia was at risk if they consumed Mn-T1-contaminated cooked (CHS) WWS and Cd-contaminated raw (RHS) and cooked (CHS) WWS at T1 and T2 because their HRI values were more than 1.

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In vitro digestion/Caco-2 cell model to estimate cadmium and lead bioaccessibility/bioavailability in two vegetables: The influence of cooking and additives

Cited by 106 publications

References 53 publications

Oral Bioaccessibility and Exposure Risk of Metal(loid)s in Local Residents Near a Mining-Impacted Area, Hunan, China

Oral Bioaccessibility and Exposure Risk of Metal(loid)s in Local Residents Near a Mining-Impacted Area, Hunan, China

Lead, Cadmium, and Arsenic Bioaccessibility of 24 h Duplicate Diet Ingested by Preschool Children Attending Day Care Centers in Brazil

Mn- and Cd-Contaminated Wild Water Spinach: in vitro Human Gastrointestinal Digestion Studies, Bioavailability Evaluation, and Health Risk Assessment

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