In vitro degradation study of polyanhydride copolymers / surface grafted hydroxyapatite composites for bone tissue application

Ku, Kuan-Lin; Grøndahl, Lisbeth; Dao, Hui; Du, Ke; Puttick, Simon; Lai, Po‐Liang; Chu, I‐Ming; Whittaker, Andrew K.

doi:10.1016/j.polymdegradstab.2017.04.021

Cited by 16 publications

(17 citation statements)

References 41 publications

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“…They prepared composite matrices in which PANH polymer was embedded into poly(ɛ-caprolactone) grafted to hydroxyapatite (PCL-gHAP). The PCL-gHAP/PANH composites demonstrated stability for at least 4 weeks with suitable mechanical properties, and in vivo studies highlighted improved functionalities of HAP in terms of new bone formation [ 51 ].…”

Section: Scaffolds For Bone Tissue Regenerationmentioning

confidence: 99%

Biodegradable Scaffolds for Bone Regeneration Combined with Drug-Delivery Systems in Osteomyelitis Therapy

et al. 2017

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A great deal of research is ongoing in the area of tissue engineering (TE) for bone regeneration. A possible improvement in restoring damaged tissues involves the loading of drugs such as proteins, genes, growth factors, antibiotics, and anti-inflammatory drugs into scaffolds for tissue regeneration. This mini-review is focused on the combination of the local delivery of antibiotic agents with bone regenerative therapy for the treatment of a severe bone infection such as osteomyelitis. The review includes a brief explanation of scaffolds for bone regeneration including scaffolds characteristics and types, a focus on severe bone infections (especially osteomyelitis and its treatment), and a literature review of local antibiotic delivery by the combination of scaffolds and drug-delivery systems. Some examples related to published studies on gentamicin sulfate-loaded drug-delivery systems combined with scaffolds are discussed, and future perspectives are highlighted.

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Section: Scaffolds For Bone Tissue Regenerationmentioning

confidence: 99%

Biodegradable Scaffolds for Bone Regeneration Combined with Drug-Delivery Systems in Osteomyelitis Therapy

et al. 2017

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“…Literature data from ref. was also included. b) Plot of initial layer thickness versus fast and slow process degradation rate constants k fast and k slow .…”

Section: Dependency Of the Degradation/erosion Rates On The Sample Thmentioning

confidence: 99%

“…It is clear from the data that the degradation rate constant is thickness dependent when considering film thickness differences of several orders of magnitude, yet it is not possible to judge from that data set what kind of correlation exists between the sample thickness and the degradation rate constants. In literature, degradation of PSA pellets with a thickness of 0.6–1.8 mm were also studied using gravimetric methods . The degradation rate constants of the these samples were fitted based on zeroth‐order kinetics, although some deviation from a zeroth‐order rate law was observed .…”

Section: Dependency Of the Degradation/erosion Rates On The Sample Thmentioning

confidence: 99%

“…In literature, degradation of PSA pellets with a thickness of 0.6–1.8 mm were also studied using gravimetric methods . The degradation rate constants of the these samples were fitted based on zeroth‐order kinetics, although some deviation from a zeroth‐order rate law was observed . The rate constants thus obtained were 0.0056 h −1 for 0.6 mm, 0.0033 h −1 for 1.2 mm, and 0.0022 h −1 for 1.8 mm thickness after 168 h .…”

Section: Dependency Of the Degradation/erosion Rates On The Sample Thmentioning

confidence: 99%

“…Polyanhydride degradation under simulated physiological conditions has been studied in some detail. In most cases, for example, for poly(sebacic anhydride) (PSA), surface erosion was observed . Depending on the exact structure of the polyanhydride studied, different degradation/erosion kinetics were observed.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Degradation of Polymer Films on Surfaces: A Model Study with Poly(sebacic anhydride)

Deng

Schweigerdt

Norow

et al. 2019

Macro Chemistry & Physics

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There is compelling evidence that the degradation kinetics of thin polymer films differ significantly from bulk materials, as interfacial effects become dominant. Therefore, it is crucial to investigate these kinetics separately. Qualitative analytics of thin film degradation exist, for example, by scanning electron microscopy or atomic force microscopy, but more quantitative studies are missing. In this work, the aliphatic poly(sebacic anhydride) (PSA) is used as a model system for a quantitative degradation study. The degradation of PSA films is monitored by ellipsometry, surface‐plasmon resonance spectroscopy (SPR), and Fourier transform infrared spectroscopy (FTIR). Two kinetic regimes are observed when plotting the relative layer thickness determined by ellipsometry and SPR against the degradation time, which corresponds to two different rates of erosion. The data obtained by FTIR show a single process corresponding to the rate of anhydride bond cleavage. Overall, the degradation rate constants of PSA determined by the different methods are consistent. They are constant for PSA films with up to 378 nm thickness. Several thicker free‐standing samples are studied gravimetrically and have a degradation rate constant that is one order of magnitude lower, thus confirming thickness‐dependent degradation rate constants for poly(sebacic anhydride).

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Recent Advances in Polyanhydride Based Biomaterials

2018

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This review focusses on recent developments of polyanhydrides, a class of degradable synthetic biopolymers. Polyanhydrides have been used as carriers for controlled delivery of drugs. A polyanhydride copolymer of carboxyphenoxy propane and sebacic acid has been used in Gliadel brain tumor implants for the controlled delivery of carmustine or bis-chloroethylnitrosourea. They are easy and inexpensive to synthesize (especially scale up). However, polyanhydrides possess a short shelf-life. Hydrolytic cleavage and anhydride interchanges lower their molecular weights during storage. One of the highlights in recent developments of polyanhydride chemistry is the discovery of alternating copolymers having extended shelf-life. Other highlights include their applications in biomedical electronics, vaccine delivery, and nano/micro particulate delivery systems. This review examines approaches for polyanhydride synthesis followed by their recent developments in biomedical applications.

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In vitro degradation study of polyanhydride copolymers / surface grafted hydroxyapatite composites for bone tissue application

Cited by 16 publications

References 41 publications

Biodegradable Scaffolds for Bone Regeneration Combined with Drug-Delivery Systems in Osteomyelitis Therapy

Biodegradable Scaffolds for Bone Regeneration Combined with Drug-Delivery Systems in Osteomyelitis Therapy

Degradation of Polymer Films on Surfaces: A Model Study with Poly(sebacic anhydride)

Recent Advances in Polyanhydride Based Biomaterials

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