In vitro degradation of Poly-L-co-D, L-lactic acid membranes

Baraúna, Grazielle S.; Coraça‐Huber, Débora C.; Duek, Eliana Aparecida de Rezende

doi:10.1590/s1516-14392012005000154

Cited by 9 publications

(8 citation statements)

References 11 publications

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“…PLLA is one of the most studied bioresorbable polymers for biomedical applications . However, some characteristics such as the long period demanded for its total degradation (around 5 years) and the high crystallinity, which can generate fragments and inflammatory reactions, can restrain its application . An alternative is to combine the two chemical forms, PLLA and PDLLA, to form a copolymer with different properties from those exhibited by each of these isolated homopolymers .…”

Section: Introductionmentioning

confidence: 99%

Characterization and in vitro evaluation of electrospun aligned‐fiber membranes of poly(L‐co‐D,L‐lactic acid)

Leal

Almeida

Dávila

et al. 2019

J of Applied Polymer Sci

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poly(L‐co‐D,L‐lactic acid) (PLDLA) is a bioresorbable and biocompatible copolymer obtained from the combination of L‐lactic and D, L‐lactic monomers. PLDLA membranes formed by aligned fibers were prepared by AC/DC electrospinning. Solutions of 8 and 10 wt % of PLDLA were used and membranes were collected by a rotating cylindrical collector. The results showed a slight increase in the fiber diameter with the increase in the polymer concentration. Fourier transform infrared spectroscopy results showed no changes in the chemical structure. Dynamic mechanical analysis results showed an increase in the storage modulus and a decrease in glass‐transition temperature for the 10 wt % samples, which was corroborated by differential scanning calorimetry. Thermogravimetric analysis showed a slight variation of the peak degradation temperature. Nevertheless, the samples did not present solvent residues. The membranes were tested in vitro using adipose‐derived mesenchymal stem cells (ASCs). The ASCs proliferated after 1, 7, and 14 days of culture, maintaining a spindle‐like morphology, which evidences their potential for tissue engineering applications. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47657.

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Section: Introductionmentioning

confidence: 99%

Characterization and in vitro evaluation of electrospun aligned‐fiber membranes of poly(L‐co‐D,L‐lactic acid)

Leal

Almeida

Dávila

et al. 2019

J of Applied Polymer Sci

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“…Among bioresorbable polymers of interest is the copolymer poly (L,co-D,L-lactic acid; PLDLA) that is widely used in the proportion 70:30 because of its good mechanical properties and excellent biocompatibility. This polymer has been the subject of study of this research group and its synthesis is already consolidated so that the polymer has high molecular weight [7][8][9][10][11][12][13][14] . Though PLA is limited by its inherent brittleness, its properties can be significantly enhanced and broadened by modification via copolymerization, which provides a number of advantages because the architecture and composition of the biomaterials can be tailored to control and composition of the biomaterials can be tailored to control the material properties (by anionic or coordinated polymerization) 15 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of a novel terpolymer based on L-lactide, D,L-lactide and trimethylene carbonate

Motta

Duek

2014

Mat. Res.

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Terpolymers of L-lactide, D,L-lactide and trimethylene carbonate (TMC) were synthesized via the ring-opening polymerization reaction for cyclic monomers using stannous octoate as the initiator at a ratio of ~0.05 mol% (monomers/(SnOct) 2 ). Synthesis was done at 130 °C for 48 h. The inclusion of TMC, an aliphatic elastomeric polycarbonate, alongside polymer chain segments containing L-lactide and D,L-lactide, was expected to yield a material with improved properties such as increased elongation; this would overcome the limitation of copolymers consisting entirely of lactide and D,L-lactide. The terpolymer properties were assessed by Nuclear magnetic resonance spectroscopy 1 H and 13 C NMR, infrared spectroscopy, differential scanning calorimetry and thermogravimetry, with particular attention being given to the effect of TMC on the copolymer of L-lactide-co-D,L-lactide. The mixing of these polymers resulted in material with a high molar mass (10 5 g/mol). The mechanical properties of the terpolymer were assessed using pins of this material that were tested by mechanical flexion at three points. When compared with results for the copolymer PLDLA there was a decrease in Young's modulus for the TMC-containing terpolymer.

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“…PLDLA copolymer is compatible with 34 and suitable for use as a bone graft substitute [35][36][37][38] , meniscus replacement 39,40 , suture cords/threads 41 and axon regeneration 42 . Cellular adhesion to biomaterials is extremely important in material sciences.…”

Section: Discussionmentioning

confidence: 99%

Lithograph-moulded poly-L-co-D,L lactide porous membranes for osteoblastic culture

et al. 2013

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Pore size, shape, wall morphology, porosity, and interconnectivity are important characteristics of the scaffolds. Lithography is a manufacturing technique that allows the production of tridimensional scaffolds with a controllable and reproducible inner architecture. The aim of this study was to use lithography to create a poly-L-co-D,L lactide (PLDLA) scaffold with symmetrical pore size and distribution, and to evaluate its biocompatibility with osteoblasts in vitro. Lithographic moulds were used to produce porous PLDLA membranes by a casting procedure. Osteoblasts were removed from calvarial bones and seeded onto porous and smooth PLDLA membranes after which cell viability and adhesion assays, cytochemical analysis and scanning electron microscopy were used to characterize the cells. Cell viability and adhesion assays, cytochemical analysis, and scanning electron microscopy were carried out. Cell viability was similar on porous and smooth PLDLA membranes but higher than on a polystyrene substrate (positive control). Although osteoblasts adhered to the surface of all the materials tested, cell adhesion to lithographed PLDLA was greater than to smooth PLDLA membranes. In conclusion, osteoblasts interacted well with PLDLA membranes, as shown by the viability and adhesion assays and by the enhanced collagen production.

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In vitro degradation of Poly-L-co-D, L-lactic acid membranes

Cited by 9 publications

References 11 publications

Characterization and in vitro evaluation of electrospun aligned‐fiber membranes of poly(L‐co‐D,L‐lactic acid)

Characterization and in vitro evaluation of electrospun aligned‐fiber membranes of poly(L‐co‐D,L‐lactic acid)

Synthesis and characterization of a novel terpolymer based on L-lactide, D,L-lactide and trimethylene carbonate

Lithograph-moulded poly-L-co-D,L lactide porous membranes for osteoblastic culture

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