In vitro degradation of chitosan by a commercial enzyme preparation: effect of molecular weight and degree of deacetylation

Zhang, Hua; Neau, Steven H.

doi:10.1016/s0142-9612(00)00326-4

Cited by 300 publications

(161 citation statements)

References 20 publications

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“…Previously chitosan was prepared using chemical and enzymatic methods [88,89]. Investigation on impact of ultrasound on chitosan molecular weight and degree acetylation revealed that 1% Chitosan in 1% acetic acid solution was sonicated at 16.5, 28.0 and 35.2Wcm -2 for 0-30 minutes, the researchers noted that the degree of acetylation was not changed while the molecular weight was reduced, the reduced sonication rate after optimum molecular weight reduction rate was attributed to many molecules with more bonds to be broken hence the rate of reducing molecular rate reduced with time after a given critical time limit.…”

Section: Sonication Of Chitinmentioning

confidence: 99%

Ultrasonic Modification of Selected Polysaccharides-Review

Ogutu¹,

Mu²,

Elahi³

et al. 2015

J Food Process Technol

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This review is a survey on ultrasonic application in selected carbohydrate polymers based upon available research reports. It covers a brief discussion on the fundamentals of ultrasound technology, before delving on the effects of ultrasound on specific polymers; pectin, chitin, starch, carrageenan and guar gum, their modification products and possible applications in food, pharmaceutical, biomedical and packaging sectors. Sonication generally leads to depolymerization and side chain break within molecules resulting into oligosugars. Oligosugars are widely used as prebiotics and specific delivery systems; moreover, nano sized products of sonication can be applied in diverse fields. Presently, ultrasonic is finding application in wider sectors therefore better understanding of the complex physico-chemical changes and mechanism of the action of high-intensity ultrasound and its effect on techno-functional properties of compounds would immensely fortify the application of ultrasonic technology.

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Section: Sonication Of Chitinmentioning

confidence: 99%

Ultrasonic Modification of Selected Polysaccharides-Review

Ogutu¹,

Mu²,

Elahi³

et al. 2015

J Food Process Technol

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“…Generally, chitosan with a lower molecular weights and lower DA, exhibit greater solubility and faster degradation than its high-molecular-weight counterparts. 13,[15][16][17][18][19] Chitosan has a pK a of approximately 6.5 on the amine groups. At pH less than about 6, chitosan's amines are protonated reflecting polycationic behavior of chitosan.…”

Section: Propertiesmentioning

confidence: 99%

Chitosan Nanoparticles: A Promising System in Novel Drug Delivery

2010

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The ability of nanoparticles to manipulate the molecules and their structures has revolutionized the conventional drug delivery system. The chitosan nanoparticles, because of their biodegradability, biocompatibility, better stability, low toxicity, simple and mild preparation methods, offer a valuable tool to novel drug delivery systems in the present scenario. Besides ionotropic gelation method, other methods such as microemulsion method, emulsification solvent diffusion method, polyelectrolyte complex method, emulsification cross-linking method, complex coacervation method and solvent evaporation method are also in use. The chitosan nanoparticles have also been reported to have key applications in parentral drug delivery, per-oral administration of drugs, in nonviral gene delivery, in vaccine delivery, in ocular drug delivery, in electrodeposition, in brain targeting drug delivery, in stability improvement, in mucosal drug delivery in controlled drug delivery of drugs, in tissue engineering and in the effective delivery of insulin. The present review describes origin and properties of chitosan and its nanoparticles along with the different methods of its preparation and the various areas of novel drug delivery where it has got its application.

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“…Nunthanid [17] reported that chitosans with high mw have higher moisture adsorption and tensile strength than those with the same DDA but lower mw. Hidaka [18] reported that a 94% DDA chitosan membranes gave minimal film degradation, mild inflammatory reaction and minimal osteogenesis while between 65 to 80% gave the opposite response.This effect is more or less in line to our survival rate results for all three different cell lines ( Figure) that the higher the degree of de-acetylation the more the survival rate and that 87% de-acetylation actually improved the cell survival rate to above 100%.…”

Section: Discussionmentioning

confidence: 99%