In vitro degradation, flexural, compressive and shear properties of fully bioresorbable composite rods

Felfel, Reda M.; Ahmed, Ifty; Parsons, Andrew J.; Walker, Gavin S.; Rudd, C.D.

doi:10.1016/j.jmbbm.2011.05.016

Cited by 54 publications

(47 citation statements)

References 29 publications

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“…The flexural strength and modulus of all PCL/PGF composite specimens in this study exhibited an initial reduction after immersion in PBS for 1 day, which was suggested to be due to plasticisation of the fibre/matrix interface by the diffused PBS within the composite specimens [14,16,28]. The diffused PBS might also cause micro cracks and stress concentration sites on the fibre surfaces and led to the reduction in composites mechanical properties [2].…”

Section: Discussionmentioning

confidence: 62%

“…The most frequently used manufacturing technique adapted for bioresorbable polymer composites is laminate stacking (LS) and hot press moulding [13][14][15]. However, a number of studies have seen a rapid loss in mechanical properties of the composites manufactured by LS after immersion in aqueous environment [2,12,16,17]. It is believed that rapid hydrolysis of the polymer/fibre interfaces happened, which reduced adhesion and prevented efficient stress transfer between matrix and reinforcement.…”

Section: Introductionmentioning

confidence: 99%

“…Instead of using resin, a reaction mixture (monomer and catalyst) was injected into moulds and polymerised in situ to form the matrix directly around the reinforcement within a single step. Since the viscosity of the monomer (ɛ-caprolactone at room temperature: 1.07 mPa s) is much lower in comparison to the polymer melt (PCL melt: 12,650 Pa s), good fibre impregnation and significantly enhanced interfacial bonding could be obtained by ISP [16]. This should lead to higher mechanical properties and a better degradation profile for the biodegradable implants.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In-situ polymerisation of fully bioresorbable polycaprolactone/phosphate glass fibre composites: In vitro degradation and mechanical properties

Chen

Parsons

Felfel

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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Fully bioresorbable composites have been investigated in order to replace metal implant plates used for hard tissue repair. Retention of the composite mechanical properties within a physiological environment has been shown to be significantly affected due to loss of the integrity of the fibre/matrix interface. This study investigated phosphate based glass fibre (PGF) reinforced polycaprolactone (PCL) composites with 20%, 35% and 50% fibre volume fractions (Vf) manufactured via an in-situ polymerisation (ISP) process and a conventional laminate stacking (LS) followed by compression moulding. Reinforcing efficiency between the LS and ISP manufacturing process was compared, and the ISP composites revealed significant improvements in mechanical properties when compared to LS composites. The degradation profiles and mechanical properties were monitored in phosphate buffered saline (PBS) at 37°C for 28 days. ISP composites revealed significantly less media uptake and mass loss (p<0.001) throughout the degradation period. The initial flexural properties of ISP composites were substantially higher (p<0.0001) than those of the LS composites, which showed that the ISP manufacturing process provided a significantly enhanced reinforcement effect than the LS process. During the degradation study, statistically higher flexural property retention profiles were also seen for the ISP composites compared to LS composites. SEM micrographs of fracture surfaces for the LS composites revealed dry fibre bundles and poor fibre dispersion with polymer rich zones, which indicated poor interfacial bonding, distribution and adhesion. In contrast, evenly distributed fibres without dry fibre bundles or polymer rich zones, were clearly observed for the ISP composite samples, which showed that a superior fibre/matrix interface was achieved with highly improved adhesion.

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Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In-situ polymerisation of fully bioresorbable polycaprolactone/phosphate glass fibre composites: In vitro degradation and mechanical properties

Chen

Parsons

Felfel

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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“…As expected, the reduction in molecular weight became more pronounced as the degradation temperature increased. During the degradation process, molecular weight decreased due to chain scission via autocatalytic hydrolysis [9,10,34]. The molecular weight distribution of PLA after degradation in PBS at 21 and 37°C was seen to be monomodal and located at the left of GPC curves (see Fig.…”

Section: Degradation Studymentioning

confidence: 95%

“…Phosphate glass fibre (PGF) production Continuous phosphate-based glass fibres were produced by melt spinning process using a dedicated in-house facility as reported previously by Felfel et al [9,10]. In brief, the glass was produced with the composition of 40P 2 O 5 -24MgO-16CaO-16Na 2 O-4Fe 2 O 3 (denoted as P40) in mol% using the sodium dihydrogen phosphate, calcium hydrogen phosphate, magnesium hydrogen phosphate trihydrate and iron phosphate dihydrate precursors (purchased from SigmaAldrich, UK).…”

Section: Materials and Methodologymentioning

confidence: 99%

Accelerated in vitro degradation properties of polylactic acid/phosphate glass fibre composites

et al. 2015

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Degradation properties were studied for polylactic acid (PLA) and phosphate glass fibre (40P 2 O 5 -24MgO-16CaO-16Na 2 O-4Fe 2 O 3 , denoted as P40) reinforced unidirectional (UD) and randomly mat (RM) PLA composites using phosphate buffer saline (PBS) media over a range of temperatures from 21 to 85°C. Glass transition and melting temperatures for PLA decreased from 61.3 and 167.4 to 52.7 and 151.6°C, respectively, and crystallinity increased from 9.2 to 58.3 % during 3 days of degradation period in PBS media at 85°C. Appearance of sharp crystalline peaks after degradation at higher temperatures which was confirmed via X-ray diffraction analysis was also indicative of increase in crystallinity. However, flexural strength decreased by approximately 20 % (for PLA) and by around 50 % (P40 RM and P40 UD composites) of the initial strength after degradation in PBS at 37°C. No significant changes in mechanical properties were observed before and after degradation of composites at 21°C for 56 days. Monomodal molecular weight distribution for the PLA before and after degradation in PBS at 37°C was replaced by bimodal after degradation at higher temperatures. Arrhenius equation applied for the change in molecular weight of the polymer and composite samples and the obtained degradation activation energies were 85.4, 78.7 and 74.1 kJ mol -1 for PLA within PLA alone, P40 RM and P40 UD composites, respectively. Time prediction was applied to correlate short-term degradation (at elevated temperatures) to the long-term effects (at 37°C) using both 'tipping point' and molecular weight as co-ordinates.

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3D‐Printed Regenerative Magnesium Phosphate Implant Ensures Stability and Restoration of Hip Dysplasia

Golafshan

Willemsen

Kadumudi

et al. 2021

Adv Healthcare Materials

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Osteoarthritis of the hip is a painful and debilitating condition commonly occurring in humans and dogs. One of the main causes that leads to hip osteoarthritis is hip dysplasia. Although the current surgical methods to correct dysplasia work satisfactorily in many circumstances, these are associated with serious complications, tissue resorption, and degeneration. In this study, a one‐step fabrication of a regenerative hip implant with a patient‐specific design and load‐bearing properties is reported. The regenerative hip implant is fabricated based on patient imaging files and by an extrusion assisted 3D printing process using a flexible, bone‐inducing biomaterial. The novel implant can be fixed with metallic screws to host bone and can be loaded up to physiological loads without signs of critical permanent deformation or failure. Moreover, after exposing the hip implant to accelerated in vitro degradation, it is confirmed that it is still able to support physiological loads even after losing ≈40% of its initial mass. In addition, the osteopromotive properties of the novel hip implant is demonstrated as shown by an increased expression of osteonectin and osteocalcin by cultured human mesenchymal stem cells after 21 days. Overall, the proposed hip implant provides an innovative regenerative and mechanically stable solution for hip dysplasia treatment.

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In vitro degradation, flexural, compressive and shear properties of fully bioresorbable composite rods

Cited by 54 publications

References 29 publications

In-situ polymerisation of fully bioresorbable polycaprolactone/phosphate glass fibre composites: In vitro degradation and mechanical properties

In-situ polymerisation of fully bioresorbable polycaprolactone/phosphate glass fibre composites: In vitro degradation and mechanical properties

Accelerated in vitro degradation properties of polylactic acid/phosphate glass fibre composites

3D‐Printed Regenerative Magnesium Phosphate Implant Ensures Stability and Restoration of Hip Dysplasia

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