In vitro degradability, bioactivity and cell responses to mesoporous magnesium silicate for the induction of bone regeneration

Wu, Zhaoying; Tang, Tingting; Guo, Han; Tang, Songchao; Niu, Yunfei; Zhang, Jue; Zhang, Wenjing; Ma, Rui; Su, Jiacan; Liu, Changsheng; Wei, Jie

doi:10.1016/j.colsurfb.2014.04.010

Cited by 60 publications

(39 citation statements)

References 32 publications

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“…Additionally, the presence of m-MS may also improve the water adsorption. 12 The water absorption increased from approximately 380% (C20) to more than 420% (C40), which could be due to the higher m-MS content in C40. With the highest water absorption ratio, C40 scaffolds were expected to be able to absorb the largest amount of body fluid after implantation in vivo, which could be conducive to the transfer of nutrients and metabolites of cells.…”

Section: Discussionmentioning

confidence: 95%

“…The weight of the scaffolds (W t ) after being removed from DI water was determined immediately after wiping off the leftover water on the surface. The water absorption ratio was calculated by 12 Water absorption ratio (%) = (W t À W 0 )/(W 0 ) Â 100%…”

Section: Compressive Strength Porosity and Water Absorptionmentioning

confidence: 99%

“…At each pre-determined time point (6,12,24,72, and 120 hours), the scaffolds were withdrawn, rinsed with DI water and air-dried at room temperature overnight. The surface morphology and phase composition of the scaffold were evaluated by SEM and energy dispersive spectroscopy (EDS, Falcon, USA), respectively.…”

Section: In Vitro Bioactivitymentioning

confidence: 99%

“…In the previous investigation, mesoporous magnesium silicate (m-MS) has been revealed to possess rapid degradability, excellent in vitro bioactivity and cytocompatibility. 12 Some researchers have confirmed that the incorporation of bioactive metal elements (such as Mg, Sr and Zn etc.) into amorphous silica walls exhibited stimulation effects on osteoblast differentiation and therefore the formation of new bone in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair

Zheng

Zhang

et al. 2016

J. Mater. Chem. B

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Bioactive scaffolds of magnesium silicate (m-MS)/poly(butylene succinate) (PBSu) composites were fabricated by a solvent casting-particulate leaching method for bone regeneration. The scaffolds had a hierarchical porous structure with interconnected macropores (300-500 mm), micropores (1-10 mm) and mesopores (B5 nm). In addition, the composite scaffolds were degradable in Tris-HCl solution and The results demonstrated that the bioactive m-MS/PBSu composite scaffolds with good biocompatibility, degradability, bioactivity and osteogenesis are promising biomaterials for bone repair.

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Section: Discussionmentioning

confidence: 95%

Section: Compressive Strength Porosity and Water Absorptionmentioning

confidence: 99%

Section: In Vitro Bioactivitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair

Zheng

Zhang

et al. 2016

J. Mater. Chem. B

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“…2,3 In the previous investigation, the nanoporous biomaterials, such as bioglass, calcium silicate and magnesium silicate (MS), have been revealed to possess improved apatite mineralization ability, degradability and drug sustained release and exhibit promotion effects on attachment, proliferation and differentiation of osteoblasts and the formation of new bone both in vitro and in vivo. [4][5][6] The large specific surface area and high pore volume of nanoporous biomaterials may improve their biological performances and allow them to be loaded with osteogenic agents and therefore promote new bone tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

Nanoporosity improved water absorption, in vitro degradability, mineralization, osteoblast responses and drug release of poly(butylene succinate)-based composite scaffolds containing nanoporous magnesium silicate compared with magnesium silicate

Pan

et al. 2017

IJN

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Bioactive composite macroporous scaffold containing nanoporosity was prepared by incorporation of nanoporous magnesium silicate (NMS) into poly(butylene succinate) (PBSu) using solvent casting–particulate leaching method. The results showed that the water absorption and in vitro degradability of NMS/PBSu composite (NMPC) scaffold significantly improved compared with magnesium silicate (MS)/PBSu composite (MPC) scaffold. In addition, the NMPC scaffold showed improved apatite mineralization ability, indicating better bioactivity, as the NMPC containing nanoporosity could induce more apatite and homogeneous apatite layer on the surfaces than MPC scaffold. The attachment and proliferation of MC3T3-E1 cells on NMPC scaffold increased significantly compared with MPC scaffold, and the alkaline phosphatase (ALP) activity of the cells on NMPC scaffold was expressed at considerably higher levels compared with MPC scaffold. Moreover, NMPC scaffold with nanoporosity not only had large drug loading (vancomycin) but also exhibited drug sustained release. The results suggested that the incorporation of NMS into PBSu could produce bioactive composite scaffold with nanoporosity, which could enhance water absorption, degradability, apatite mineralization and drug sustained release and promote cell responses.

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How Does Scaffold Porosity Conduct Bone Tissue Regeneration?

et al. 2021

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Despite progresses in tissue healing, repairing large bone defects remains an unmet challenge. Tissue engineering (TE) using porous scaffolds offers great promise in providing solutions by which bone healing can be increased, and the need for further surgical intervention can be reduced. Nonetheless, the successful performance of a porous scaffold depends on key structural factors including porosity, pore size, geometry, and interconnectivity. Herein, recent advancements on this topic are reviewed and the effects of fabrication methods on making potential scaffolds for advanced bone regeneration are discussed.The upward trend of population aging, increased numbers of accidents, sport injuries, trauma, and bone tumor resection are increasing the demand for substitutes to regenerate and/or repair damaged skeletal and dental bones. [1] Bone tissue poses a simple yet highly organized ultracomposition in which each portion plays a pivotal role in moderating the elasticity and strength of the bone. [2] The intrinsically dynamic bone tissue structure allows the restoration of damaged parts via the self-healing process. [3] This remodeling process is dependent on the dynamic equilibrium between the bone-forming (osteoblast) and bone-resorbing cells (osteoclast) during mechanical stimulation. [4] Nevertheless, this healing process is not sufficient for repairing massive and critical bone defects; thus, there is a need for drastic healing accelerators and substitutive or supportive therapeutics. [5] Specially, the regenerating of large bone defects is a serious and challenging clinical issue. To address the issue, different types of bone graft substitutes such as autografts, allografts, and xenografts are used. [6] These grafts, however, come with certain drawbacks, including donor site morbidity and limited supply. Moreover, aged persons cannot provide rich bone tissue for their own tissue replacement due to osteoporosis. [7] To address the limitations associated with natural bone-derived substitutes, biomaterials have been developed during recent decades. [8] Engineering biomaterials made it possible to simulate the bone microenvironment and construct programmable scaffolds for purposeful therapeutic procedures. Bioactive ceramic materials are favorable for bone tissue engineering (BTE) due to their resemblance to the mineral phase of bone, and direct bonding with host bone tissue without the formation of fibrous tissue. In addition, the variety in the chemical composition of bioceramics, particularly silicate-based ceramics (SiCa), can contribute to adjustments in mechanical properties, bioactivity, and biodegradability.A fundamental constituent of engineering tissue is the scaffold, which acts as the structural template providing a suitable substrate for cell proliferation, differentiation, and attachment resulting in new tissue formation. In tissue engineering (TE), the scaffold serves as the structural guide and the substrate for cell anchorage. The scaffold also contributes to the remodeling of the extracellular mat...

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In vitro degradability, bioactivity and cell responses to mesoporous magnesium silicate for the induction of bone regeneration

Cited by 60 publications

References 32 publications

Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair

Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair

Nanoporosity improved water absorption, in vitro degradability, mineralization, osteoblast responses and drug release of poly(butylene succinate)-based composite scaffolds containing nanoporous magnesium silicate compared with magnesium silicate

How Does Scaffold Porosity Conduct Bone Tissue Regeneration?

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