In Vitro Cytotoxic and Anticancer Effects of Zamzam Water in Human Lung Cancer (A594) Cell Line

Omar, Ulfat M.; Doghaither, Huda A. Al; Rahimulddin, Sawsan A.; Zahrani, Shiekhah M Al; Al‐Ghafari, Ayat B.

doi:10.21315/mjms2017.24.3.3

Cited by 12 publications

(5 citation statements)

References 25 publications

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“…Zamzam water contains larger amounts of fluoride, calcium and magnesium compounds, compared to other types of water, and has been shown to have antimicrobial, anti-inflammatory and anticancer properties. In addition, its cytotoxic effect has been shown on different cells lines such as lung, breast, and ovarian cells, as well as on tumors in animal models, via the inhibition of cancer pathogenetic pathways such as CRAF, MEK1/2, ERK1/2, and P38 phosphorylation ( Omar et al, 2017 , Boshra et al, 2021 , Abd-Allah, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Muslim pilgrims’ knowledge, attitudes, and practices regarding complementary and alternative medicine (CAM); a study conducted during Hajj season

Alqathama,

Ahmad

2024

Saudi Pharmaceutical Journal

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Section: Discussionmentioning

confidence: 99%

Muslim pilgrims’ knowledge, attitudes, and practices regarding complementary and alternative medicine (CAM); a study conducted during Hajj season

Alqathama,

Ahmad

2024

Saudi Pharmaceutical Journal

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“…Zamzam Water: The Prophet PBUH said, "The water of Zamzam is good for whatever it is drunk for," (Ibn Majah: 3062). Several studies found that Zamzam water showed cytotoxicity and anticancer effects against human colon, breast, lung, and uterine cancer cell lines (Abd-Rabou et al, 2018;Al Zahrani et al, 2019;Omar et al, 2017). 6.…”

Section: Tawakkul (Reliance On God)mentioning

confidence: 99%

Natural Product as Chemoprevention from Maqasid Shariah Perspective: A Narrative Review

Azalan,

Abdul Ghani

2023

RAS

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Chemoprevention strategies, which aim to prevent or reduce the risk of cancer using natural products, align with the Maqasid Shariah by promoting the preservation of life and the protection of health, which are fundamental objectives of Islamic law. This review aimed to understand the role of natural products (plants source) as chemoprevention from Maqasid Shariah viewpoint. The study of natural products as chemoprevention and their conceptualization are in parallel with the Al-Qur’an and As-Sunnah were found through a thorough search of the literature. Chemoprevention is a type of intervention that, in accordance with the first principle of Maqasid Shariah which emphasis on the preservation of life (hifz al-nafs). Several types of natural products from plant resources mentioned in Al-Qur'an and Al-Hadith for instance, dates, figs, olive, fennel, acacia, cucumber, pomegranate, ginger, onion, and black cumin possessed medicinal properties for disease treatments and anti-cancer effects. While different cancer types respond differently to natural products as anticancer agents, this review has identified categories of plants with chemopreventive efficacy in parallel with the concept of Maqasid Shariah that can serve as a guide for additional in-depth research in the biomedical sciences field.Keywords: chemoprevention, Maqasid Shariah perspective, natural products, plants

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“…Some reported that arsenic and nitrate levels were three times higher than World Health Organization (WHO) limits ( Shomar, 2012 ) and others reported that arsenic levels were within acceptable limits ( Al-Barakah et al, 2016 ). I n vitro studies on cancer cells have reported that treating cancer cells with Zamzam water induced antiproliferative and apoptotic effects and it was suggested that the anticancer effects could be due to the high pH of the water and the presence of heavy metals such as arsenic ( Al Doghaither et al, 2016 , Omar et al, 2017 , Al Zahrani et al, 2019 ). A study on rats has observed a reduction in tumor size after treating the rats with Zamzam water, and the authors suggested that the possible reason for the reduction in the size of the tumor was due to the biochemical nature of Zamzam water ( Ali et al, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Biochemical and histological effects of five weeks ingestion of Zamzam water on the liver and kidneys of Wistar rats

Doghaither

Al-Sohaibani

Omar

et al. 2021

Saudi Pharmaceutical Journal

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Zamzam water is a natural alkaline water which has become alkaline as a result of the natural environment. It comes from what is considered as one of the oldest springs in the world. The water contains high concentrations of alkaline minerals as well as trace and heavy metals. The aim of the current study is to evaluate the effects of five weeks ingestion of Zamzam water on the liver and kidney functions of rats. Adult female Wistar rats weighing 150–200 g were divided into two groups, with 15 rats in each. The control group was supplied daily by bottled water and the Zamzam water group was supplied daily by 500 ml of Zamzam water for five weeks. The rats were weighed weekly and, at the end of the experiment, blood samples were collected from all rats for the biochemical determination of serum levels of aspartate transaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), urea, creatinine, albumin, and uric acid, using calorimetric methods. Liver and kidney tissues were fixed in 10% neutral buffered-formalin solution and further embedded in wax blocks for routine hematoxylin and eosin (H&E) staining and were examined for histopathological changes using a light microscope. The results of the current study showed that there was a significant increase ( P < 0.05) in the weight of the Zamzam group when compared to the control group after five weeks of ingestion. Liver and kidney function tests did not show any significant difference when compared with the controls ( P > 0.05). In addition, histological examination of the liver and kidney tissues did not show any toxicological changes. In conclusion, the results showed that the ingestion of Zamzam water did not alter serum levels of kidney function tests and liver enzymes; and did not result in a noticeable change in the liver and kidney histology. Thus, the high concentrations of elements in Zamzam water do not induce hepatotoxicity or nephrotoxicity and the water is considered safe for long-term consumption.

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In Vitro Cytotoxic and Anticancer Effects of Zamzam Water in Human Lung Cancer (A594) Cell Line

Cited by 12 publications

References 25 publications

Muslim pilgrims’ knowledge, attitudes, and practices regarding complementary and alternative medicine (CAM); a study conducted during Hajj season

Muslim pilgrims’ knowledge, attitudes, and practices regarding complementary and alternative medicine (CAM); a study conducted during Hajj season

Natural Product as Chemoprevention from Maqasid Shariah Perspective: A Narrative Review

Biochemical and histological effects of five weeks ingestion of Zamzam water on the liver and kidneys of Wistar rats

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