In vitro cytotoxic activity of (-)-ent-costunolide (Notes)

MyungJu, Kim; Lee, Jae-Sug; Baek, Seung‐Hwa

doi:10.3742/opem.2009.9.1.097

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“…Among them, subfraction 2, that eluted with 5% and 10% ethyl acetate -hexane, is the most cytotoxic activity to murine leukaemia cells ATCC CCL 46 P388D1 (37.1 mg, P388 IC 5 0 945 ng/ml at 7.5 µg/disc). A comparison of IC 5 0 (ng/ml) values of these subfractions in cancer cells showed susceptibility to these subfractions decreased in the following order; subfraction 2 > 4 > 1 = .3 Kim et al, 2009). The result shows the potent cytotoxic activity of (-)-ent-costunolide (1) from H. paucistipula against P388 murine leukaemia cell lines (P 388 IC 5 0 687 ng/ml) and BSC monkey kidney cell lines (100% of well at 15 µg/disk).…”

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confidence: 98%

In vitro Biological Activity of Germacranolide sesquiterpene lactones

MyungJu¹,

Lee²,

Baek³

2009

Oriental Pharmacy and Experimental Medicine

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Bioactivity-directed isolation has led to the isolation of (-)-ent-costunolide (1) as the major active compound from Hepatostolonophora paucistipula. This compound (1) was determined by spectroscopic data interpretation. This sesquiterpene lactone (1) inhibited the growth of the dermatophytic fungus Trichophyton mentagrophytes ATCC 28185, (4 mm inhibition zone at 15 µg/ disc), cytotoxic activity to murine leukaemia cell lines ATCC CCL 46 P 388D1 (IC 5 0 687 ng/ml, at 0.075 µg/disk), BSC monkey kidney cell lines (100% of well at 15 µg/disk) and antiviral activity to Herpes simplex virus (0.25 mg/ml, 100% of well at 7.5 µg/disk) and Polio virus (0.125 mg/ml, 100% of well at 3.75 µg/disk). These results suggest that (-)-ent-costunolide (1) has potential antimicrobial and cytotoxic agents.

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Section: 'mentioning

confidence: 98%