In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica

Fronza, Márcio; Murillo, R.; Ślusarczyk, Sylwester; Adams, Michael; Hamburger, Matthias; Heinzmann, Berta Maria; Laufer, Stefan; Merfort, Irmgard

doi:10.1016/j.bmc.2011.06.067

Cited by 84 publications

(57 citation statements)

References 28 publications

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“…The seven known compounds were identified as mandarone A (1) [11], taxusabietane A (2) [12], 12-O-demethylcrypto-japonol (3) [13], cryptojaponol (4) [14], 11,14-dihydroxy-8,11,13-abietatrien-7-one (5) [15], fortunin E (6) [16], fortunin F (7) [16], by comparison of their spectra with those reported in the literature. Phytochemical investigations on Clerodendrum species revealed various diterpenoids in the plants, which showed antibacterial and cytotoxic activities [8,9].…”

Section: Resultsmentioning

confidence: 99%

“…The 1 H-and 13 C-NMR spectroscopic data ( The seven known compounds were identified as mandarone A (1) [11], taxusabietane A (2) [12], 12-O-demethylcrypto-japonol (3) [13], cryptojaponol (4) [14], 11,14-dihydroxy-8,11,13-abietatrien-7-one (5) [15], fortunin E (6) [16], fortunin F (7) [16], by comparison of their spectra with those reported in the literature. To investigate their cytotoxic activities, these compounds were evaluated using an MTT cytotoxicity assay against human myeloid leukemia (HL-60), hepatocellular carcinoma (SMMC-7721), lung cancer (A-549) and breast cancer (MCF-7) cell lines.…”

Section: Resultsmentioning

confidence: 99%

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Bioactive Diterpenoids from Clerodendrum kiangsiense

Wang

Jia

et al. 2016

Molecules

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Abstract:A new abeo-abietane diterpenoid, 12-methoxy-6,11,14,16-tetrahydroxy-17(15Ñ16)-abeo-5,8,11,13-abietatetraen-3,7-dione (8), was isolated from the hydroalcoholic extract of the herb of Clerodendrum kiangsiense along with seven known diterpenoids (1-7). Their structures were identified on the basis of spectroscopic analyses including two-dimensional NMR and comparison with literature data. All of these compounds were evaluated for their cytotoxic activities against the growth of human cancer cells lines HL-60, SMMC-7721, A-549 and MCF-7 by the MTT assay. The results showed that cryptojaponol (4), fortunin E (6) and 8 exhibited significant cytotoxicity against four human cancer cell lines.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Bioactive Diterpenoids from Clerodendrum kiangsiense

Wang

Jia

et al. 2016

Molecules

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“…By means of this technique, it is possible to analyse and identify volatile compounds, such as terpenoids, which compose both EOs and volatile fractions of extracts obtained with apolar organic solvents, among them hexane (Fronza et al . ; Bandeira Junior et al . ).…”

Section: Methodsmentioning

confidence: 96%

Extracts of Hesperozygis ringens (Benth.) Epling: in vitro and in vivo antibacterial activity against fish pathogenic bacteria

et al. 2019

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Aims This study investigated the in vitro antibacterial activity of Hesperozygis ringens (Benth.) Epling leaf extracts against fish pathogenic bacteria, as well as the in vivo activity of the most active extract in silver catfish (Rhamdia quelen) experimentally infected with Aeromonas hydrophila. Moreover, the chemical composition of the extract used in the survival assay was evaluated. Methods and Results Only hexane extract (HEHR) showed in vitro antibacterial activity (MIC and MBC ranging from 1600 to 3200 μg ml−1) against clinical isolates of A. hydrophila, Raoultella ornithinolytica and Citrobacter freundii, obtained from naturally infected silver catfish, and A. hydrophilaATCC 7966. The major compound of the volatile fraction of HEHR was determined as pulegone. HEHR promoted a 93·33% relative survival rate of silver catfish experimentally infected with A. hydrophila 7 days after a single therapeutic bath at 30 mg l−1, while florfenicol at 4 mg l−1, which promoted a 60% relative survival rate. Conclusions The antibacterial activity of H. ringens (Benth.) Epling leaf extracts seems to be related to phytochemicals of apolar character, since HEHR promoted better survival rate of infected animals than florfenicol. Significance and Impact of the Study The HEHR has potential to be used in the control and treatment of bacterial infections in organic aquaculture.

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“…Compounds 1 and 3 showed cytotoxic activity against human pancreatic cancer cell line; MIAPaCa-2 with IC 50 = 10.18 and 22.5 μg/mL, respectively (Fronza et al 2011), while compound 4 was the most active anticancer agent (IC 50 = 4.7 and 7.4 μg/mL) against both MIAPaCa-2 and melanoma (MV-3) cancer cell lines, respectively (Fronza et al 2011). Compound 3 showed cytotoxic activity against multidrug-resistant human CEM/ADR5000 leukaemia cells lines, comparable to those reported for established natural anticancer agents, paclitaxel and vincristine (Efferth et al 2008).…”

Section: Introductionmentioning

confidence: 98%

The roots of Salvia rhytidea: a rich source of biologically active diterpenoids

Jassbi

Eghtesadi

Hazeri

et al. 2016

Natural Product Research

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Sahandinone (1), 12-deoxysalvipisone (2), miltirone (3), 7α-acetoxyroyleanone (4), and labda-7,14-dien-13-ol (5) were isolated from the roots of Salvia rhytidea Benth. (Lamiaceae). Their structures were elucidated by a combination of spectroscopic analyses including EIMS and NMR. The C NMR spectroscopic data were revised for the quaternary carbons of both 1 and 3 with the help of HMBC spectra in respect to the spectral data previously reported in the literature. Compounds 1 and 3, two very potent anticancer agents, were isolated in high yields from the roots of the plant. The biological activities of the plants' constituents were reported in the literature as antimicrobial, cytotoxic and antimalarial are discussed in this article.

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In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica

Cited by 84 publications

References 28 publications

Bioactive Diterpenoids from Clerodendrum kiangsiense

Bioactive Diterpenoids from Clerodendrum kiangsiense

Extracts of Hesperozygis ringens (Benth.) Epling: in vitro and in vivo antibacterial activity against fish pathogenic bacteria

The roots of Salvia rhytidea: a rich source of biologically active diterpenoids

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