In Vitro Cytotoxic Activity and Identification of Bioactive Compounds Isolated from Olea europaea and Syzygium aromaticum Plants

Okasha, Hend; Abdel-Hady, Heba; Morsi, Eman; El-Wakil, Eman Ahmed; Shemis, Mohamed

doi:10.1007/s11094-022-02761-5

Cited by 1 publication

(1 citation statement)

References 40 publications

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“…Clove leaf oil treated with HepG2 cells shows an IC50 value of 50.62 µg mL −1 , showing its cytotoxic effect. [ 121 ] Another study revealed that caffeic acid (one of the bioactive constituent of clove) possesses hepatoprotective activity in HCC by inducing autophagy and inhibiting TGF β expression. [ 122 ]…”

Section: Role Of Indian Culinary Spices In Mitigating Hcc Progressionmentioning

confidence: 99%

Role of Culinary Indian Spices in the Regulation of TGF‐β Signaling Pathway in Inflammation‐Induced Liver Cancer

Asoka,

Kolikkandy,

Nair

et al. 2024

Molecular Nutrition Food Res

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ScopeHepatocellular carcinoma (HCC) results from various etiologies, such as Hepatitis B and C, Alcoholic and Non‐alcoholic fatty liver disorders, fibrosis, and cirrhosis. About 80 to 90% of HCC cases possess cirrhosis, which is brought on by persistent liver inflammation. TGF‐β is a multifunctional polypeptide molecule that acts as a pro‐fibrogenic marker, inflammatory cytokine, immunosuppressive agent, and pro‐carcinogenic growth factor during the progression of HCC. The preclinical and clinical evidence illustrates that TGF‐β can induce epithelial‐to‐mesenchymal transition, promoting progression and hepatocyte immune evasion. Therefore, targeting the TGF‐β pathway can be a promising therapeutic option against HCC.Methods and ResultsWe carry out a systemic analysis of eight potentially selected culinary Indian spices: Turmeric, Black pepper, Ginger, Garlic, Fenugreek, Red pepper, Clove, Cinnamon, and their bioactives in regulation of the TGF‐β pathway against liver cancer.ConclusionTurmeric and its active constituent, curcumin, possess the highest therapeutic potential in treating inflammation‐induced HCC and they also have the maximum number of ongoing in‐vivo and in‐vitro studies.

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Section: Role Of Indian Culinary Spices In Mitigating Hcc Progressionmentioning

confidence: 99%

Role of Culinary Indian Spices in the Regulation of TGF‐β Signaling Pathway in Inflammation‐Induced Liver Cancer

Asoka,

Kolikkandy,

Nair

et al. 2024

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

In Vitro Cytotoxic Activity and Identification of Bioactive Compounds Isolated from Olea europaea and Syzygium aromaticum Plants

Cited by 1 publication

References 40 publications

Role of Culinary Indian Spices in the Regulation of TGF‐β Signaling Pathway in Inflammation‐Induced Liver Cancer

Role of Culinary Indian Spices in the Regulation of TGF‐β Signaling Pathway in Inflammation‐Induced Liver Cancer

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