In vitro combined activity of amphotericin B, caspofungin and voriconazole against clinical isolates of Trichosporon asahii

Li, Houmin; Lu, Qiaoyun; Wan, Zhe; Zhang, Jianzhong

doi:10.1016/j.ijantimicag.2010.01.013

Cited by 26 publications

(17 citation statements)

References 12 publications

(14 reference statements)

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“…Voriconazole also has excellent in vitro activity against Trichosporon strains and may be useful for treating patients with trichosporonosis, including cases of acute leukemia and myelodysplasic syndrome with disseminated infection (12,57,106,118,140,160).…”

Section: Antifungal Therapymentioning

confidence: 99%

Current Knowledge of Trichosporon spp. and Trichosporonosis

2011

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SUMMARY Trichosporon spp. are basidiomycetous yeast-like fungi found widely in nature. Clinical isolates are generally related to superficial infections. However, this fungus has been recognized as an opportunistic agent of invasive infections, mostly in cancer patients and those exposed to invasive medical procedures. It is possible that the ability of Trichosporon strains to form biofilms on implanted devices, the presence of glucuronoxylomannan in their cell walls, and the ability to produce proteases and lipases are all factors likely related to the virulence of this genus and therefore may account for the progress of invasive trichosporonosis. Disseminated trichosporonosis has been increasingly reported worldwide and represents a challenge for both diagnosis and species identification. Phenotypic identification methods are useful for Trichosporon sp. screening, but only molecular methods, such as IGS region sequencing, allow the complete identification of Trichosporon isolates at the species level. Methods for the diagnosis of invasive trichosporonosis include PCR-based methods, Luminex xMAP technology, and, more recently, proteomics. Treating patients with trichosporonosis remains a challenge because of limited data on the in vitro and in vivo activities of antifungal drugs against clinically relevant species of the genus. Despite the mentioned limitations, the use of antifungal regimens containing triazoles appears to be the best therapeutic approach.

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Section: Antifungal Therapymentioning

confidence: 99%

Current Knowledge of Trichosporon spp. and Trichosporonosis

2011

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“…However, it is difficult to explain how the echinocandin MICs are lowered when the drug is together with amphotericin B 7 . In our study, the patient used amphotericin B together with caspofungin and was cured of the fungal infection.…”

Section: Resultsmentioning

confidence: 99%

Isolation and antifungal susceptibility testing of Trichosporon asahii in Ceará, Brazil

Menezes

Marinho

Ângelo

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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SUMMARYTrichosporon spp. are yeasts capable of causing invasive disease, which mainly affect immunocompromised patients. A clinical strain of T. asahii was isolated from the blood cultures of patients admitted to the General Hospital of Fortaleza. Susceptibility tests were conducted by disk diffusion and broth microdilution. The isolated strain of T. asahii was resistant to fluconazole. The patient used amphotericin B and caspofungin in order to facilitate the microbiological cure. It was the first isolation and identification of T. asahii in blood culture in Ceará, Brazil.

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“…Six Trichosporon species (T. asahii, T. asteroides, T. cutaneum, T. inkin, T. mucoides, and T. ovoides) cause superficial and/ or invasive infections. T. asahii is the most frequent Trichosporon species involved in disseminated human infections [5][6][7][8][9][10]. To date, only few cases of Trichosporon asahii fungemia were reported in Saudi Arabia [11].…”

Section: Discussionmentioning

confidence: 99%

A Trichosporon asahii Bloodstream Infection in a Preterm Newborn with a Successful Outcome: A Case Report

Ma¹,

Sam²,

El-Shalakany³

et al. 2017

J Blood Lymph

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Trichosporon asahii is a rare opportunistic fungal pathogen that causes fatal systemic infections in immunocompromised patients. We have reported a case of T. asahii fungemia in a low birth weight preterm newborn baby in the neonatal intensive care unit (NICU). This case of T. asahii fungemia was unresponsive to treatment with a combination of Amphotericin B and Fluconazole. However, Treatment with a combination of Voriconazole and Caspofungin was successfully eliminated the fungus from the blood of the infected patient.

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In vitro combined activity of amphotericin B, caspofungin and voriconazole against clinical isolates of Trichosporon asahii

Cited by 26 publications

References 12 publications

Current Knowledge of Trichosporon spp. and Trichosporonosis

Current Knowledge of Trichosporon spp. and Trichosporonosis

Isolation and antifungal susceptibility testing of Trichosporon asahii in Ceará, Brazil

A Trichosporon asahii Bloodstream Infection in a Preterm Newborn with a Successful Outcome: A Case Report

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