In vitro chloramphenicol detection in a Haemophilus influenza model using an aptamer-polymer based electrochemical biosensor

A “signal-on’’ aptasensor for simultaneous detection of chloramphenicol and polychlorinated biphenyls using multi-metal ions encoded nanospherical brushes as tracers

“…3B and C). The limit of detection was found to be 0.3 pg mL À 1 (at S/N ¼3), which were competitive with or even better than other reported single analyte determination assays (Table S1) (Wu et al, 2015;Yadav et al, 2014;Xu et al, 2012;Poli et al, 2009;Pilehvar et al, 2014). Consequently, a sensitive and simultaneous determination of the two analytes was achieved.…”

“…As a broad-spectrum antibiotic, chloramphenicol (CAP) is widely used in animals as the growth promoters and the treatment of diseases. However, it has been found that the excessive levels of CAP which exists in fish, shrimp and pork have some side effects such as aplastic anemia, gray baby syndrome, and leukemia which would threaten public health Yang and Zhao, 2014;Yadav et al, 2014). Polychlorinated biphenyls (PCBs) are a group of highly persistent organic compounds, which are used as additives in pesticides, paints, as well as sealants.…”

“…Various analytical methods and techniques are used for the determination of CAP or PCBs, including gas chromatographymass spectrometry (Sapozhnikova and Lehotay, 2013;Ottonello et al, 2014), and high-performance liquid chromatography (Posyniak et al, 2003;Yadav et al, 2014;Yang and Zhao, 2014;Silva et al, 2007). These traditional separation-based methods are sensitive, reliable and stable, but their high cost and complicated operation limit their application.…”

“…Thus, in the study, CAP, PCB72 were used as a model for detection in fish samples. Moreover, it's urgent to develop a kind of sensitive and quick assay to enable screen monitor of the residues of CAP and PCB72 together in food samples Yan et al, 2012;Yadav et al, 2014).…”

Advance Diagnosis of Drug Resistance in Cancer: Towards Point-of-Care Electronic Nanodevice

“…While these methods have been applied for the detection of drug resistant cancer cells (DRCC), but they are less sensitive, need extremely trained professionals, and lacks the ability to be miniaturized for the onsite medical detection. In recent years, electrochemical nanosensors are found to be the most promising approach to resolve the issues related to sensitivity, rapidity, selectivity, and ability to be miniaturized [8][9][10][11][12][13][14][15][16][17]. Thus, in biosensorbased detection technologies have been also attempted for the detection of DRCC.…”