In vitro chemoprotective and anticancer activities of propolis in human lymphocytes and breast cancer cells

Milošević-Djordjević, Olivera; Grujičić, Darko; Radović, Marina; Vuković, Nenad; Žižić, Jovana B.; Marković, Snežana D.

doi:10.2298/abs141013019m

Cited by 8 publications

(3 citation statements)

References 41 publications

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“…The mechanism of EEP’s growth inhibition seemed to be mediated by reducing NF-κB activity. In another study, Milosevic-Djordjevic et al studied the in vitro activity of propolis against carcinogenesis in lymphocytes and breast cancer cells as well as how EEP in combination with mitomycin C affected the chemotherapeutic properties of the latter [ 188 ]. The findings revealed a concentration- and time-dependent anticancer effect of EEP, which was higher in cells exposed to a combination of propolis and mitomycin C. Padmavathi et al also reported enhancement of paclitaxel cytotoxicity against breast cancer in female mice exposed to propolis [ 189 ].…”

Section: Synergistic Effect Of Propolis With Other Anticancer Agentsmentioning

confidence: 99%

Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms

et al. 2023

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Cancer is the second most life-threatening disease and has become a global health and economic problem worldwide. Due to the multifactorial nature of cancer, its pathophysiology is not completely understood so far, which makes it hard to treat. The current therapeutic strategies for cancer lack the efficacy due to the emergence of drug resistance and the toxic side effects associated with the treatment. Therefore, the search for more efficient and less toxic cancer treatment strategies is still at the forefront of current research. Propolis is a mixture of resinous compounds containing beeswax and partially digested exudates from plants leaves and buds. Its chemical composition varies widely depending on the bee species, geographic location, plant species, and weather conditions. Since ancient times, propolis has been used in many conditions and aliments for its healing properties. Propolis has well-known therapeutic actions including antioxidative, antimicrobial, anti-inflammatory, and anticancer properties. In recent years, extensive in vitro and in vivo studies have suggested that propolis possesses properties against several types of cancers. The present review highlights the recent progress made on the molecular targets and signaling pathways involved in the anticancer activities of propolis. Propolis exerts anticancer effects primarily by inhibiting cancer cell proliferation, inducing apoptosis through regulating various signaling pathways and arresting the tumor cell cycle, inducing autophagy, epigenetic modulations, and further inhibiting the invasion and metastasis of tumors. Propolis targets numerous signaling pathways associated with cancer therapy, including pathways mediated by p53, β-catenin, ERK1/2, MAPK, and NF-κB. Possible synergistic actions of a combination therapy of propolis with existing chemotherapies are also discussed in this review. Overall, propolis, by acting on diverse mechanisms simultaneously, can be considered to be a promising, multi-targeting, multi-pathways anticancer agent for the treatment of various types of cancers.

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Section: Synergistic Effect Of Propolis With Other Anticancer Agentsmentioning

confidence: 99%

Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms

et al. 2023

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“…In addition to antiangiogenic effects, and modification of the tumor microenvironment [26,51]. Brazilian green propolis has been found to significantly contribute to the management of chemokinemediated inflammation [52].…”

Section: Cytotoxicity and Growth Inhibitory Potential On Hepg2 And Hc...mentioning

confidence: 99%

Antioxidant And Anti-Mycotoxin Activities, And Cytotoxicity Properties In Vitro Of Propolis Extracts

Rasmy,

Saleh,

Hassan

et al. 2023

J. Adv. Zool.

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The present study aims to determine the antioxidant activity and cytotoxic activity of propolis and evaluate the anti-mycotoxin activity of different propolis extracts. The three extracts of propolis (ethyl acetate, ethanol (75%), and water) were subjected to testing of the antioxidant potential, and total phenolic and flavonoid contents. determination of the cytotoxicity activity by standard cell culture method against colon and liver and the ability of propolis extracts to control aflatoxin (AF) production. The results revealed that the highest value of antioxidant activities was found for propolis ethyl acetate extract with an average % inhibition of 63.42%. the highest amount of propolis's total phenolic and flavonoid contents using ethyl acetate extract were 149.5 µg gallic acid equivalent/mg extract and 218.1 µg quercetin equivalent/mg extract, respectively. The three propolis extracts affect liver and colon human cell cancer. Ethyl acetate extract of propolis showed the lowest IC50 with the highest anti-cancer activity on the liver cancer cell line. In comparison, water extract showed the lowest IC50 with the greatest anticancer activity on the colon cancer cell line (50 and 54 µg/ml, respectively). Using different concentrations of propolis to reduce AF levels led to the complete disappearance of AF production at 100, 200, and 400 mg/ml concentrations of Ethyl acetate extract against AF production. In conclusion, these obtained findings indicated that propolis extracts exhibited substantial antioxidant and anti-cancer activities.

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“…Regarding free flavonoids, the main contributors to antioxidant activity are epigallocatechin, epicatechin and rutin [ 8 ]. The phenolic extracts from propolis exhibited a certain level of in vitro anti-mutagenic activity in lymphocytes from healthy subjects, and anti-cancer activity in breast cancer cell lines and may be considered as safe and healthy food supplements in cancer therapy [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of chemical composition in the buds of Aralia elata from different geographical origins of China

Hua

Peng

et al. 2018

R. Soc. open sci.

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Aralia elata buds contain many nutrients and have a pleasant taste with a unique flavour. Previous studies mainly focused on triterpene saponins in the root bark of this species, but little information existed concerning other chemical components, especially in the buds. To better understand the nutritional value of A. elata, we compared total flavonoids, total saponins, phenolic compounds and mineral element contents in the buds of A. elata collected from eight different geographical regions (S1: Benxi; S2: Linjiang; S3: Pingwu; S4: Enshi; S5: Changbaishan; S6: Shangzhi; S7: Xiaoxinganling and S8: Harbin) in China. The results showed that the basic composition in the buds presented a wide variation, with ash (8.76–10.35%), crude fibre (5.38–11.07%), polysaccharides (33.85–46.79 mg g−1), total flavonoid content (TFC, 4.06–48.63 mg g−1) and total saponins (13.62–27.85 mg g−1). UPLC combined with the LC-MS/MS method was used for the phenolic compounds analysis, and 11 phenolic compounds were identified and quantified in the eight samples. The total phenolic content in Enshi (S4) was significantly higher than others, and quercetin was the predominant phenolic compound in this sample. We used ICP-OES to identify and quantify nine mineral elements in the buds. The Fe and Cu contents in S5 were much higher than that of others. We obtained maximum Mg, Mn, Co and Ni contents in S4, and found rich Zn content in S7. Moreover, the maximum estimated quantities of Ca and Sr were found in S8. This study indicated that the chemical composition in the buds of A. elata was obviously affected by geographical origin. Our results provided an essential theoretical basis of quality evaluation of A. elata buds in the food production field.

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In vitro chemoprotective and anticancer activities of propolis in human lymphocytes and breast cancer cells

Cited by 8 publications

References 41 publications

Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms

Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms

Antioxidant And Anti-Mycotoxin Activities, And Cytotoxicity Properties In Vitro Of Propolis Extracts

Comparison of chemical composition in the buds of Aralia elata from different geographical origins of China

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