In vitro chemopreventive potential of fucophlorethols from the brown alga Fucus vesiculosus L. by anti-oxidant activity and inhibition of selected cytochrome P450 enzymes

Parys, Sabine; Kehraus, Stefan; Krick, Anja; Glombitza, Karl‐Werner; Carmeli, Shmuel; Klimo, Karin; Gerhäuser, Clarissa; König, Gabriele M.

doi:10.1016/j.phytochem.2009.10.020

Cited by 92 publications

(71 citation statements)

References 35 publications

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“…Reactive oxygen species play a key role in the initiation and promotion phase of carcinogenesis (Parys et al, 2010). To detect radical-scavenging potential of purified compounds, we used three different free radical systems.…”

Section: Discussionmentioning

confidence: 99%

“…Chronic inflammation contributes to tumor promotion through the action of prostaglandins as inflammatory mediators and has been estimated to be associated to 15% of malignancies (Parys et al, 2010). COX, the key enzyme in prostaglandin biosynthesis (Michaux et al, 2005), and hyaluronidase, an enzymatic activity increased during chronic inflammation, are targets of chemoprevention and could be used as marker systems for antitumor-promoting potential.…”

Section: Discussionmentioning

confidence: 99%

“…Several of the reported biological activities of phenols, such as free radical scavenging activities or anti-inflammatory potential have been also associated with cancer chemopreventive potential (Parys et al, 2010). Tripodanthus acutifolius (Ruiz and Pavón) Van Tieghem (Loranthaceae) is an endemic shrub that grows in various arid and semiarid regions of South America (between 1800 and 2700 m on sea level), including northwestern and northeastern Argentina (Abbiatti, 1943;Daud et al, 2005), bolivian andean region (Macía et al, 2005), and southern of Brazil (Alice et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

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Free radical scavenging activities and inhibition of inflammatory enzymes of phenolics isolated from Tripodanthus acutifolius

Soberón¹,

Sgariglia²,

Sampietro³

et al. 2010

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Free radical scavenging activities and inhibition of inflammatory enzymes of phenolics isolated from Tripodanthus acutifolius

Soberón¹,

Sgariglia²,

Sampietro³

et al. 2010

Journal of Ethnopharmacology

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“…From these, fucols and fucophlorethols are the predominant compounds found in Fucus spp. [230,231,232,233,234]. …”

Section: Other Nutritional Elementsmentioning

confidence: 99%

Phycochemical Constituents and Biological Activities of Fucus spp.

2018

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Seaweeds are known to be a good supply of key nutrients including carbohydrates, protein, minerals, polyunsaturated lipids, as well as several other health-promoting compounds capable of acting on a wide spectrum of disorders and/or diseases. While these marine macroalgae are deeply rooted in the East Asian culture and dietary habits, their major application in Western countries has been in the phycocolloid industry. This scenario has however been gradually changing, since seaweed consumption is becoming more common worldwide. Among the numerous edible seaweeds, members of the genus Fucus have a high nutritional value and are considered good sources of dietary fibers and minerals, especially iodine. Additionally, their wealth of bioactive compounds such as fucoidan, phlorotannins, fucoxanthin and others make them strong candidates for multiple therapeutic applications (e.g., antioxidant, anti-inflammatory, anti-tumor, anti-obesity, anti-coagulant, anti-diabetes and others). This review presents an overview of the nutritional and phytochemical composition of Fucus spp., and their claimed biological activities, as well as the beneficial effects associated to their consumption. Furthermore, the use of Fucus seaweeds and/or their components as functional ingredients for formulation of novel and enhanced foods is also discussed.

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“…A comparison of PMR and 13 C NMR spectroscopic data with the literature classified fraction 11.3.20 as a fucophlorethol phlorotannin [12,13]. Polymeric phenols of this class belong to Fucus type phlorotannins [14].…”

mentioning

confidence: 80%

Brown Alga Metabolites – Inhibitors of Marine Organism Fucoidan Hydrolases

et al. 2017

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Fucoidan hydrolase inhibitors were discovered for the first time. Metabolites in the aqueous EtOH extract of Fucus evanescens inhibited specifically the activity of enzymes involved in catabolism of brown-alga polysaccharides, i.e., fucoidanases (recombinant FFA from the marine bacterium Formosa algae KMM 3553T and PPF from the marine mollusk Patinopecten yessoensis) and glycosidases (recombinant D-L-fucosidase FucFa from F. algae and E-D-glucosidase G-II from the marine mollusk Littorina sitkana). The purified fucophlorethol fraction isolated from this extract inhibited recombinant fucoidanase FFA in the concentration range 10-50 Pg/mL.Enzyme-catalyzed biochemical reactions are fundamental to in vivo metabolic processes. Enzyme inhibitors are very significant in pharmacology and toxicology and are used to study enzyme mechanisms of action and establish the active-site structures because of their high specificity.Carbohydrase inhibitors from natural sources have stimulated unwavering interest. Enzyme inhibitors in nature are known to act often as interspecies relationship regulators. For example, amylase inhibitors from grain sprouts are toxic for insects and mammals. Furthermore, amylase inhibitors were detected among so-called pathogen-responsive proteins (PR-proteins) involved in the plant protective mechanism. Amylases and glycosidases are the most studied natural inhibitors. Their effects on plant-insect relationships or forage animals are being actively studied [1,2].Brown algae, like terrestrial plants, protect themselves from predation by marine invertebrates or microorganisms by synthesizing alginate lyases, laminarinases, and fucoidanases. Reports of carbohydrase inhibitors from marine sources are very sparse [3,4], as for fucoidanase producers [5,6].We discovered several sources that biosynthesize active fucoidan hydrolases [7,8]. The role of these enzymes and; correspondingly, their inhibitors, is difficult to overestimate because all brown algae synthesize fucoidans. The total mass of these polysaccharides in nature is enormous and should be utilized in some manner.The goal of the present research was to seek fucoidan hydrolase inhibitors among metabolites of brown algae inhabiting the seas of the Russian Far East.Enzymes involved in brown alga polysaccharide catabolism were used to discover inhibitors. These were highly purified fucoidanases (recombinant FFA from the marine bacterium Formosa algae KMM 3553T [7] and PPF from the marine mollusk Patinopecten yessoensis [6]) and glycosidases (E-D-glucosidase G-II from the marine mollusk Littorina sitkana [9] and recombinant D-L-fucosidase FucFa from F. algae). Recombinant D-L-fucosidase FucFa was prepared especially for this research because it is involved in fucoidan catabolism. E-D-Glucosidase G-II, which catalyzes hydrolysis of laminarioligosaccharides and laminaran, was used to demonstrate the specificity of the discovered fucoidan hydrolase inhibitors. Fucoidan from Fucus evanescens was used as the substrate for the fucoidanases; p-Np-D-L-fuco-and ...

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In vitro chemopreventive potential of fucophlorethols from the brown alga Fucus vesiculosus L. by anti-oxidant activity and inhibition of selected cytochrome P450 enzymes

Cited by 92 publications

References 35 publications

Free radical scavenging activities and inhibition of inflammatory enzymes of phenolics isolated from Tripodanthus acutifolius

Free radical scavenging activities and inhibition of inflammatory enzymes of phenolics isolated from Tripodanthus acutifolius

Phycochemical Constituents and Biological Activities of Fucus spp.

Brown Alga Metabolites – Inhibitors of Marine Organism Fucoidan Hydrolases

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