Free radical scavenging activities and inhibition of inflammatory enzymes of phenolics isolated from Tripodanthus acutifolius

Soberón, José Rodolfo; Sgariglia, Melina Araceli; Sampietro, Diego Alejandro; Quiroga, Emma Nelly; Vattuone, Marta Amelia

doi:10.1016/j.jep.2010.05.015

Cited by 35 publications

(25 citation statements)

References 32 publications

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“…In agreement with our study, previous in vitro research reported that 30 different flavonoid components exhibited inhibition against BTHase, and that inhibition levels were determined, from highest to lowest, in silibinin4kaempferol4apigenin4luteolin4tan-nin 33 . The idea that flavonoids possess anti-hyaluronidase activity has also been supported by other studies 4,8,12,34 .…”

Section: Resultsmentioning

confidence: 54%

“…HA inhibitors have also led to new therapeutic concepts in pathophysiological conditions, such as laryngeal or breast cancer treatment, that are associated with the hyaluronanhyaluronidase system 3,4,7 . Since the partial control of hyaluronidases possesses several important physiological functions, they have recently attracted considerable scientific interest as synthetic and natural inhibitors 4,[8][9][10][11][12] . Honey and bee products are natural materials whose antioxidant, anti-inflammatory and anti-tumoral efficacies vary depending on the flora from which they are produced.…”

Section: Introductionmentioning

confidence: 99%

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Honey shows potent inhibitory activity against the bovine testes hyaluronidase

Kolaylı

Şahin

Can

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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The purpose of this study was to investigate the anti-hyaluronidase activities of honeys from different botanical origins honeys in order to determine their anti-inflammatory properties. The total phenolic contents, total flavonoids and total tannin levels of six types of honey, chestnut, oak, heather, pine, buckwheat and mixed blossom, were determined. Concentrationrelated inhibition values were tested turbidimetrically on bovine testis hyaluronidase (BTHase) as IC 50 (mg/mL). All honeys exhibited various concentration-dependent degrees of inhibition against BTHase. Inhibition values varied significantly depending on honeys' levels of phenolic contents, flavonoid and tannin. The honeys with the highest anti-hyaluronidase activity were oak, chestnut and heather. In conclusion, polyphenol-rich honeys have high anti-hyaluronidase activity, and these honeys have high protective and complementary potential against hyaluronidase-induced anti-inflammatory failures.

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Section: Resultsmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Honey shows potent inhibitory activity against the bovine testes hyaluronidase

Kolaylı

Şahin

Can

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Research has demonstrated the protective effects of blueberries against atherosclerosis in apolipoprotein E-deficient (apoE −/− ) mice; the potential mechanisms may involve a reduction in oxidative stress due to both inhibition of lipid peroxidation and the enhancement of antioxidant defense 18) . In recent studies, extracts of hawthorn fruit have been shown to inhibit LDL and liposome oxidation in cell cultures and significantly reduce the levels of lipid hydroperoxides in humans 19,20) . Analyses of hawthorn fruit extract using chemical methods have indicated that hawthorn is a promising plant due to its high antioxidant activity 21) .…”

Section: Preparation Of the Hawthorn Fruit And Animalsmentioning

confidence: 99%

Hawthorn Fruit Attenuates Atherosclerosis by Improving the Hypolipidemic and Antioxidant Activities in Apolipoprotein E-Deficient Mice

Zhang

Geng

et al. 2014

JAT

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Aims:The protective effects of hawthorn fruit against atherosclerosis and the potential underlying mechanisms of this fruit in improving the hypolipidemic and antioxidant activities were investigated in apolipoprotein E-deficient (apoE −/− ) mice. Methods: ApoE −/− mice were divided into a control group (n = 10) and hawthorn fruit group (n = 10). The mean size of the lesions in the aortic root was assessed, and the serum glucose levels, insulin levels, lipid profiles, total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activities were measured. The mRNA levels of hepatic genes related to lipid metabolism and antioxidant enzymes were examined. Results: The hawthorn fruit group mice developed significantly decreased (p＜0.05) atherosclerotic lesions. The levels of serum lipids decreased significantly (p＜0.05) and the levels of cholesterol/triglycerides, including very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL), decreased in the hawthorn fruit group. The hawthorn fruit mice exhibited significantly increased T-AOC values and SOD and GSH-PX activities (p＜0.05). The hepatic fatty acid synthase (FAS) and sterol regulatory element binding protein-1c (SREBP-1c) mRNA levels were reduced by 42% (p＜ 0.05) and 23% p＜0.05) in the mice fed the hawthorn fruit diet compared with that observed in the mice fed a standard diet. However, the hepatic hydroxymethylglutaryl CoA reductase (HMG-CoAR) mRNA levels showed no significant differences between the two groups. The mRNA expression levels of the antioxidant enzymes (SOD1, SOD2, Gpx3) were higher (p＜0.05) in the livers of the hawthorn fruit diet mice compared with those observed in the control mice. Conclusions: Hawthorn fruit exerts a protective effect against atherosclerosis in apoE −/− mice by improving the hypolipidemic and antioxidant activities.

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“…From the flavonoid glycosides determined in the current study, astragalin (Lee et al, 2011), isoquercitrin (Rogerio et al, 2007), nicotiflorin (Soberon et al, 2010) and rutin (Lee et al, 2015), as well as chlorogenic acids (Liang and Kitts, 2016) have been previously stated as demonstrating anti-inflammatory activity.…”

Section: Anti-inflammatory Activitymentioning

confidence: 69%

Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago

Svobodová

Barros

Calhelha

et al. 2017

Industrial Crops and Products

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a b s t r a c tA wild variety of bitter melon Momordica charantia L. (Cucurbitaceae) has been used in bush medicine of Trinidad and Tobago for treatment of diabetes, inflammations and cancer. Despite many studies regarding the cultivated bitter melon, the wild variety has been poorly investigated. This study evaluates the biological activities of the ethanol/water extract of aerial parts and correlates these activities with the presence of phenolic compounds. The extract exhibited antioxidant activity in the four assays (DPPH, reducing power, ␤-carotene bleaching and TBARS). The key role of oxidative stress in inflammation and tumorigenesis was supported by the results of anti-inflammatory (inhibition of nitric oxide production) and cytotoxicity (human tumor cell lines, namely HeLa, HepG2, MCF-7, and NCI-H460) assays. In contrast, no toxicity was observed in non-tumor cells. In the antibacterial screening, clinical resistant isolates were significantly affected (MIC 50 = 10-0.625 g/mL), being Listeria monocytogenes the most susceptible. Three phenolic acids and eleven flavonol glycosides derivatives were identified, quercetin-3-O-pentosylhexoside being the most abundant.

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Free radical scavenging activities and inhibition of inflammatory enzymes of phenolics isolated from Tripodanthus acutifolius

Cited by 35 publications

References 32 publications

Honey shows potent inhibitory activity against the bovine testes hyaluronidase

Honey shows potent inhibitory activity against the bovine testes hyaluronidase

Hawthorn Fruit Attenuates Atherosclerosis by Improving the Hypolipidemic and Antioxidant Activities in Apolipoprotein E-Deficient Mice

Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago

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