In vitro characterization of the immunotoxic potential of several perfluorinated compounds (PFCs)

Corsini, Emanuela; Sangiovanni, Enrico; Avogadro, Anna; Galbiati, Valentina; Viviani, Bárbara; Marinovich, Marina; Galli, C. L.; Dell’Agli, Mario; Germolec, Dori R.

doi:10.1016/j.taap.2011.11.004

Cited by 139 publications

(99 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In vitro, PFDA exposure decreased secretion of TNFa and IL-6 in stimulated human peripheral blood leukocytes (hPBL) and in THP-1 cells, decreased secretion of interferon (IFN)-c by stimulated hPBL, and inhibited NF-jB activation in stimulated THP-1 cells. However, PFDA failed to activate PPARa-driven transcription in THP-1 cells (Corsini et al 2012). Collectively, these data support an alternative PPARa-independent, possibly NF-jB-driven, mechanism in immune cells.…”

Section: Treatmentmentioning

confidence: 58%

Immunotoxic and hepatotoxic effects of perfluoro-n-decanoic acid (PFDA) on female Harlan Sprague–Dawley rats and B₆C₃F₁/N mice when administered by oral gavage for 28 days

Frawley

Smith

Cesta

et al. 2018

Journal of Immunotoxicology

View full text Add to dashboard Cite

Poly-and perfluoroalkyl substances (PFAS) are chemically and thermally stable, hydrophobic, lipophobic compounds used in stain repellants and water and oil surfactants, and associated with immunosuppression and peroxisome proliferator activity. Perfluoro-n-decanoic acid (PFDA, (CF 3 (CF 2 ) 8 COOH), a fluorinated straight chain fatty acid compound, is reported to induce thymic atrophy and reversible bone marrow hypocellularity in rodent models. The objective of this study was to assess potential immunotoxicity of PFDA, due to its structural similarity to other immunosuppressive PFASs. Female Harlan Sprague-Dawley rats were exposed to 0-2.0 mg PFDA/kg by oral gavage daily for 28 d. Female B 6 C 3 F 1 /N mice were exposed once/week to 0-5.0 mg PFDA/kg by gavage for 4 weeks. Animals were evaluated for effects on immune cell populations in spleen and bone marrow, and innate, humoral-, and cell-mediated immunity. Mice were also evaluated for resistance to Influenza virus. Treatment-related hepatocyte necrosis and hepatomegaly were observed in rats treated with 0.5 mg PFDA/kg/d. In mice, hepatomegaly (26-89%) was observed following exposure to !0.625 mg PFDA/kg/week, while splenic atrophy (20%) was observed at 5.0 mg PFDA/kg/week. At 5.0 mg PFDA/kg/week, total spleen cells, and Ig þ and NK þ cells were decreased (17.6-27%). At ! 1.25 mg PFDA/kg/week the numbers of splenic CD3 þ , CD4 þ , CD8 þ , and Mac3 þ cells were decreased (10.5-39%). No changes were observed in leukocyte subpopulations in PFDA-exposed rats. Phagocytosis by fixed-tissue macrophages was decreased in liver (specific activity, 24-39%) at !0.25 mg PFDA/kg/d in rats. PFDA-induced effects on humoral-and cell-mediated immunity, host resistance, and bone marrow progenitor cells were limited. These data suggest that exposure to PFDA may induce adverse effects in rat liver in a manner consistent with the PFAS class, and may also alter the balance of immune cell populations in lymphoid tissues in mice.ARTICLE HISTORY

show abstract

Section: Treatmentmentioning

confidence: 58%

Immunotoxic and hepatotoxic effects of perfluoro-n-decanoic acid (PFDA) on female Harlan Sprague–Dawley rats and B₆C₃F₁/N mice when administered by oral gavage for 28 days

Frawley

Smith

Cesta

et al. 2018

Journal of Immunotoxicology

View full text Add to dashboard Cite

show abstract

“…Effluents from wastewater treatment plants (domestic as well as industrial) are pointed out as the major point sources of these compounds to the water bodies (Clara et al 2008). Moreover, increasing number of published research reports suggests potential negative impacts of PFCs in water environment on aquatic life and human health (Lau et al 2004;Corsini et al 2012;Domingo 2012).…”

Section: Introductionmentioning

confidence: 99%

Oxidative–reductive photodecomposition of perfluorooctanoic acid in water

Giri

Ozaki

Guo

et al. 2013

Int. J. Environ. Sci. Technol.

View full text Add to dashboard Cite

This article aims to elucidate on usefulness of vacuum ultraviolet (VUV) for photoreductive degradation of perfluorooctanoic acid (PFOA), a representative perfluorinated compound (PFC), in water for the first time. Bench-scale tests were conducted on oxidative and reductive (with aquated electron: e aq -) mineralization of PFOA using low-pressure UV (LPUV) lamps and potassium iodide. Unlike with 254 nm wavelength (UVC), the reductive mineralization with VUV was very inefficient compared to the corresponding oxidative mineralization. The inefficiency is attributed to low reactivity of e aq -with PFOA and its fluorinated products than that of 185 nm photons. Direct VUV photolysis of PFOA and its products in reductive reaction conditions was not apparent due to a very big difference in reactivity of 185 and 254 nm photons with iodide. The results demonstrated that highly energetic VUV photons are not suitable for photoreductive degradations of PFCs involving e aq -, but they can be best used for oxidative degradations. These findings should serve as an important reference on VUV usage to decompose refractory micropollutants.

show abstract

“…Reports concerning the immunotoxicity of PFOS in vitro and in vivo have appeared in the literature (Keil et al, 2008;Lefebvre et al, 2008;Peden-Adams et al, 2008;Dong et al, 2009;Qazi et al, 2009;Brieger et al, 2011;Mollenhauer et al, 2011;Wang et al, 2011;Zheng et al, 2011;Corsini et al, 2012;Dewitt et al, 2012). However, there is still a lack of understanding of the toxicokinetics and mode(s)/mechanism(s) of immunotoxic action of PFOS.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of perfluorooctanesulfonate (PFOS)-induced apoptosis in the immunocyte

Zhang

Wang

Dong

et al. 2012

Journal of Immunotoxicology

View full text Add to dashboard Cite

In vitro characterization of the immunotoxic potential of several perfluorinated compounds (PFCs)

Cited by 139 publications

References 47 publications

Immunotoxic and hepatotoxic effects of perfluoro-n-decanoic acid (PFDA) on female Harlan Sprague–Dawley rats and B₆C₃F₁/N mice when administered by oral gavage for 28 days

Immunotoxic and hepatotoxic effects of perfluoro-n-decanoic acid (PFDA) on female Harlan Sprague–Dawley rats and B₆C₃F₁/N mice when administered by oral gavage for 28 days

Oxidative–reductive photodecomposition of perfluorooctanoic acid in water

Mechanism of perfluorooctanesulfonate (PFOS)-induced apoptosis in the immunocyte

Contact Info

Product

Resources

About

In vitro characterization of the immunotoxic potential of several perfluorinated compounds (PFCs)

Cited by 139 publications

References 47 publications

Immunotoxic and hepatotoxic effects of perfluoro-n-decanoic acid (PFDA) on female Harlan Sprague–Dawley rats and B6C3F1/N mice when administered by oral gavage for 28 days

Immunotoxic and hepatotoxic effects of perfluoro-n-decanoic acid (PFDA) on female Harlan Sprague–Dawley rats and B6C3F1/N mice when administered by oral gavage for 28 days

Oxidative–reductive photodecomposition of perfluorooctanoic acid in water

Mechanism of perfluorooctanesulfonate (PFOS)-induced apoptosis in the immunocyte

Contact Info

Product

Resources

About

Immunotoxic and hepatotoxic effects of perfluoro-n-decanoic acid (PFDA) on female Harlan Sprague–Dawley rats and B₆C₃F₁/N mice when administered by oral gavage for 28 days

Immunotoxic and hepatotoxic effects of perfluoro-n-decanoic acid (PFDA) on female Harlan Sprague–Dawley rats and B₆C₃F₁/N mice when administered by oral gavage for 28 days